SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_003010
Gene Symbol: MAP2K4
Description: Homo sapiens mitogen-activated protein kinase kinase 4 (MAP2K4), mRNA.
Gene Location: chr17(+):11924134-12047051
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr17:g.12141495G>C COSN15374215 AOCS-093-3-6 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1206 ctcttttgtCATGAACAta
 14
 UGUUCAUG m8a (m7b->m8a) -0.079000 -0.284000 No effect
hsa-miR-433 ctcttttgTCATGAacata
 12
 AUCAUGAU m6b Created -0.087000 -0.161000 -0.060000
hsa-miR-1206 ctcttttgtCATGAACAta
 14
 UGUUCAUG m8a (m7b->m8a) -0.079000 -0.284000 No effect
hsa-miR-433 ctcttttgTCATGAacata
 12
 AUCAUGAU m6b Created -0.087000 -0.161000 -0.060000
hsa-miR-1206 ctcttttgtCATGAACAta
 14
 UGUUCAUG m8a (m7b->m8a) -0.079000 -0.284000 No effect
hsa-miR-433 ctcttttgTCATGAacata
 12
 AUCAUGAU m6b Created -0.087000 -0.161000 -0.060000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.12141664T>C COSN8602349 4095_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1324 tactaTGTCTGaacataga
 10
 CCAGACAG m6b Disrupted -0.084000 no TS 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.12141794C>A COSN8602350 J90_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4803 tgtgataTTATGTTgcttt
 0 UAACAUAA m7b Created no TS -0.012000 -0.650000
hsa-miR-5692b tgtgATATTATgttgcttt
 17
 AAUAAUAU m7b Created 0.022000 0.054000 -4.260000
hsa-miR-5692c tgtgATATTATgttgcttt
 17
 AAUAAUAU m7b Created 0.022000 0.054000 -4.720000
hsa-miR-889 tgtGATATTAtgttgcttt
 0 UUAAUAUC m7b (m6b->m7b) no TS -0.034000 -1.200000


Mutation Mutation ID Sample Name Cancer Type
chr17:g.12141814T>C cosmic_v64_1760539 Leukemia/T-ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr17:g.12142065C>T cosmic_v64_1760524 Leukemia/T-ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2277-3p ggtgtGCTGTCAacttgat
 0 UGACAGCG m7a Created -0.112 -0.208 -0.35
hsa-miR-4715-5p ggtgtgctGCCAACTTgat
 0 AAGUUGGC m8a Disrupted -0.12 no TS 0.27
hsa-miR-885-3p ggtgtGCTGCCaacttgat
 16
 AGGCAGCG m6b Disrupted -0.12 no TS 8.81

Mutation Mutation ID Sample Name Cancer Type
chr17:g.12142080A>C ICGC_68CDEBAC-2A78-11E2-898B-FFFC496BB9B8 CPCG_0020_Pr_P_F0 [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1207-5p tgatgttccCCCTGCCAca
 0 UGGCAGGG m8a (m7b->m8a) -0.064 -0.199 -2.12
hsa-miR-1909-3p tgatgttcCCCCTGCcaca
 0 CGCAGGGG m7b Created no TS -0.114 -6.9
hsa-miR-3665 tgatgttcCACCTGCcaca
 0 AGCAGGUG m7b Disrupted -0.195 -0.122 11.6
hsa-miR-4716-3p tgatgtTCCCCCTgccaca
 0 AAGGGGGA m7b Created no TS -0.144 -0.09
hsa-miR-4736 tgatgttccACCTGCCaca
 0 AGGCAGGU m7b (m7b->m6c) -0.163 -0.077 1.33
hsa-miR-4763-3p tgatgttccCCCTGCCaca
 0 AGGCAGGG m7b (m6c->m7b) -0.064 -0.199 -2.67
hsa-miR-625-5p tgatgTTCCCCCTgccaca
 0 AGGGGGAA m8a Created -0.145 -0.225 -0.12
hsa-miR-657 tgatgttccACCTGCCaca
 0 GGCAGGUU m7a (m7a->m6b) NA NA 3.49

Mutation Mutation ID Sample Name Cancer Type
chr17:g.12142588G>A COSN6650014 CHC433T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-29b-1-5p gacacattgAACCAGatga
 0 GCUGGUUU m6b Created no TS -0.006000 -0.830000
hsa-miR-3663-5p gacacattgGACCAGatga
 7
 GCUGGUCU m6b Disrupted -0.049000 no TS -0.570000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.12142915C>A cosmic_v64_1760532 Leukemia/T-ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-182-3p ttacAGAACCAaatcgtgg
 8
 UGGUUCUA m7a Disrupted -0.031 0.029 0.01
hsa-miR-218-1-3p ttacaGAACCAaatcgtgg
 8
 AUGGUUCC m6b Disrupted -0.049 no TS 6.08
hsa-miR-375 ttacaGAACAAAatcgtgg
 0 UUUGUUCG m7a Created no TS 0.009 -6.23
hsa-miR-4273 ttacAGAACAaaatcgtgg
 0 GUGUUCUC m6b Created no TS -0.013 -1.31
hsa-miR-4677-5p ttacAGAACAAaatcgtgg
 0 UUGUUCUU m7a Created no TS -0.002 No effect
hsa-miR-5002-5p ttacagaACCAAATcgtgg
 7
 AAUUUGGU m7b Disrupted 0.061 0.049 0.21
hsa-miR-659-3p ttacaGAACCAAatcgtgg
 8
 CUUGGUUC m7b Disrupted -0.102 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr17:g.12143153G>A cosmic_v64_1760519 Leukemia/T-ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4327 tcgaccacaGCAAGCCatc
 0 GGCUUGCA m7a (m7a->m6b) NA NA 5.3409

Mutation Mutation ID Sample Name Cancer Type
chr17:g.12143306A>G cosmic_v64_1760536 Leukemia/T-ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5003-5p gaccgttcTGTTGTGtgga
 0 UCACAACA m7b Created no TS -0.081 -0.71
hsa-miR-5687 gacCGTTCTAttgtgtgga
 3
 UUAGAACG m7b (m7b->m6b) -0.115 no TS 0.14

Mutation Mutation ID Sample Name Cancer Type
chr17:g.12143323A>G COSN1713429 RK180_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-299-3p gatgaCCACATAagaaggc
 12
 UAUGUGGG m7a Disrupted -0.097000 no TS No effect
hsa-miR-4491 gatgaCCACATaagaaggc
 12
 AAUGUGGA m6b Disrupted -0.096000 no TS No effect
hsa-miR-4657 gatgaCCACATaagaaggc
 12
 AAUGUGGA m6b Disrupted -0.096000 no TS No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
12141661 rs1049438 G G hsa-miR-1324
10
 tactaTGTCTGAa
 Disrupted
N
 -0.084
A hsa-miR-3942-3p
hsa-miR-5100
11
11
 tactatATCTGAA
tactatATCTGAA
 Created
Created
N
N
 -0.128
-0.056
12142065 rs186704791 C C hsa-miR-4715-5p
hsa-miR-7150
hsa-miR-885-3p
14
18
16
 gtgctGCCAACTt
gtgCTGCCAActt
gtGCTGCCAactt
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.12
-0.065
-0.12
T hsa-miR-2277-3p
16
 gtGCTGTCAactt
 Created
N
 -0.096
12142080 rs201362372 A A hsa-miR-3665
hsa-miR-4736
11
13
 tgttcCACCTGCc
tgttccACCTGCC
 Disrupted
Disrupted
N
N
 -0.073
-0.086
C hsa-miR-1207-5p
hsa-miR-1909-3p
hsa-miR-4716-3p
hsa-miR-4763-3p
hsa-miR-625-5p
hsa-miR-6722-3p
hsa-miR-6794-5p
hsa-miR-6798-5p
13
11
10
13
10
11
10
9
 tgttccCCCTGCC
tgttcCCCCTGCc
tgtTCCCCCTgcc
tgttccCCCTGCC
tgTTCCCCCtgcc
tgttcCCCCTGCc
tgtTCCCCCTgcc
tgttCCCCCTGcc
 Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
 -0.135
-0.114
-0.144
-0.135
-0.08
-0.114
-0.144
-0.178
12142588 rs4792219 G G hsa-miR-3663-5p
hsa-miR-7152-3p
7
2
 acattgGACCAGA
acattGGACCAGA
 Disrupted
Disrupted
N
N
 -0.049
-0.2
A hsa-miR-29b-1-5p
7
 acattgAACCAGA
 Created
N
 -0.006
12143306 rs185090127 A A hsa-miR-5687
3
 CGTTCTAttgtgt
 Disrupted
N
 -0.115
G hsa-miR-5003-5p
6
 cgttcTGTTGTGt
 Created
N
 -0.081

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