SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_002345
Gene Symbol:	LUM
Description:	Homo sapiens lumican (LUM), mRNA.
Gene Location:	chr12(-):91497231-91505542
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.91103506A>C			COSN1593390		RK147_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-let-7a-3p	actTTGTATAtaaaataca	0	CUAUACAA	m7b	(m7b->m6c)	-0.161000	no TS	9.020000
hsa-let-7b-3p	actTTGTATAtaaaataca	0	CUAUACAA	m7b	(m7b->m6c)	-0.161000	no TS	2.950000
hsa-let-7f-1-3p	actTTGTATAtaaaataca	0	CUAUACAA	m7b	(m7b->m6c)	-0.152000	no TS	6.130000
hsa-miR-1185-1-3p	acttTGTATATaaaataca	0	AUAUACAG	m7a	Disrupted	NA	NA	4.070000
hsa-miR-1185-2-3p	acttTGTATATaaaataca	0	AUAUACAG	m7a	Disrupted	NA	NA	5.660000
hsa-miR-4760-5p	actttgtATCTAAAataca	0	UUUAGAUU	m7a	Created	no TS	-0.084000	-1.350000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.91103584A>G			COSN5870536		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4477a	gttatgtTTAATAagctac	3	CUAUUAAG	m6b	Disrupted	0.033000	no TS	0.050000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.91103714T>C			COSN7386929		8016470		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-223-5p	caaAATACACGaagcttca	0	CGUGUAUU	m8a	Created	no TS	-0.143000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.91103802T>C			COSN5870537		RK181_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4708-3p	atgttactcCCTTGCacca	0	AGCAAGGC	m6b	Created	no TS	-0.155000	-9.550000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.91104104A>G			COSN1153601		HCC85T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1246	tttcatagtATCCATattt	0	AAUGGAUU	m6b	Disrupted	-0.146000	no TS	0.830000
hsa-miR-1261	tttcatagTATCCATattt	0	AUGGAUAA	m7a	Disrupted	NA	NA	3.440000
hsa-miR-3117-5p	tttcaTAGTGTCcatattt	0	AGACACUA	m7b	Created	no TS	-0.250000	-4.190000
hsa-miR-1246	tttcatagtATCCATattt	0	AAUGGAUU	m6b	Disrupted	-0.146000	no TS	0.830000
hsa-miR-1261	tttcatagTATCCATattt	0	AUGGAUAA	m7a	Disrupted	NA	NA	3.440000
hsa-miR-3117-5p	tttcaTAGTGTCcatattt	0	AGACACUA	m7b	Created	no TS	-0.250000	-4.190000
hsa-miR-1246	tttcatagtATCCATattt	0	AAUGGAUU	m6b	Disrupted	-0.146	no TS	0.83
hsa-miR-1261	tttcatagTATCCATattt	0	AUGGAUAA	m7a	Disrupted	NA	NA	3.44
hsa-miR-3117-5p	tttcaTAGTGTCcatattt	0	AGACACUA	m7b	Created	no TS	-0.25	-4.19

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
91103511	rs76869463	T	T	hsa-let-7a-3p hsa-let-7b-3p hsa-let-7f-1-3p hsa-miR-300 hsa-miR-381-3p hsa-miR-3973 hsa-miR-4666a-3p hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-548av-5p hsa-miR-548k hsa-miR-8054 hsa-miR-98-3p	2 2 2 2 2 0 2 0 0 0 0 0 2	gtactTTGTATAt gtactTTGTATAt gtactTTGTATAt gtactTTGTATAt gtactTTGTATAt gTACTTTGtatat gtactTTGTATAt gtaCTTTGTAtat gtaCTTTGTAtat GTACTTTgtatat GTACTTTgtatat GTACTTTgtatat gtactTTGTATAt	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N N N	-0.161 -0.161 -0.152 -0.07 -0.063 -0.179 -0.06 -0.181 -0.181 -0.203 -0.203 -0.175 -0.171
			C	hsa-let-7d-3p hsa-miR-5585-5p	2 0	gtactTCGTATAt GTACTTCgtatat	Created Created	N N	-0.326 -0.243

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