SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000627
Gene Symbol:	LTBP1
Description:	Homo sapiens latent transforming growth factor beta binding protein 1 (LTBP1), transcript variant 2, mRNA.
Gene Location:	chr2(+):33359663-33624575
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.33398772A>T			COSN1237900		HCC56T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3646	tctgTTCATTTgtaaaatt	8	AAAAUGAA	m7b	Created	-0.065000	-0.078000	-0.010000
hsa-miR-520d-5p	tctgttcaTTTGTAaaatt	1	CUACAAAG	m6b	Created	-0.080000	-0.075000	-0.010000
hsa-miR-524-5p	tctgttcaTTTGTAaaatt	1	CUACAAAG	m6b	Created	-0.098000	-0.099000	-0.010000
hsa-miR-5580-3p	tctgttCATATGTaaaatt	16	CACAUAUG	m7b	Disrupted	-0.287000	-0.037000	0.850000
hsa-miR-3646	tctgTTCATTTgtaaaatt	0	AAAAUGAA	m7b	Created	-0.065	-0.078	-0.01
hsa-miR-520d-5p	tctgttcaTTTGTAaaatt	0	CUACAAAG	m6b	Created	-0.08	-0.075	-0.01
hsa-miR-524-5p	tctgttcaTTTGTAaaatt	0	CUACAAAG	m6b	Created	-0.098	-0.099	-0.01
hsa-miR-5580-3p	tctgttCATATGTaaaatt	16	CACAUAUG	m7b	Disrupted	-0.287	-0.037	0.85

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.33398896T>G			COSN1836400		RK014_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3124-3p	tggtGGAAAGattttatat	0	ACUUUCCU	m6b	Created	no TS	-0.083000	-0.010000
hsa-miR-4668-3p	tggtggaaaGATTTTatat	0	GAAAAUCC	m6b	Created	0.049000	0.050000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.33399051C>T			COSN1836401		RK012_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4645-5p	aattcccgGCCTGGagcat	0	ACCAGGCA	m6b	Disrupted	-0.137000	no TS	0.970000
hsa-miR-4645-5p	aattcccgGCCTGGagcat	0	ACCAGGCA	m6b	Disrupted	-0.137	no TS	0.97

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
33399165	rs151061295	T	T	hsa-miR-1324	9	ttTGTCTGAtttt	Disrupted	N	-0.119
			G	hsa-miR-4668-3p	13	tttgtcGGATTTT	Created	N	-0.113

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