SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_014646
Gene Symbol: LPIN2
Description: Homo sapiens lipin 2 (LPIN2), mRNA.
Gene Location: chr18(-):2916991-3011945
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr18:g.2917061A>G COSN1737352 RK006_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr18:g.2917340A>T COSN6119151 RK149_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr18:g.2917658A>G COSN7464814 8068548 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-101-3p tttttggGTACTGTgttgt
 4
 UACAGUAC m7b Disrupted -0.051000 no TS 0.020000
hsa-miR-3065-3p tttttgGGTGCTGtgttgt
 5
 UCAGCACC m7b Created -0.134000 -0.261000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.2918594C>G COSN4772228 tumor_4139696 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1275 aaagctTCCCCCAgcttaa
 2
 GUGGGGGA m7b Disrupted -0.146000 -0.079000 0.350000
hsa-miR-25-5p aaagctTCCGCCagcttaa
 0 AGGCGGAG m6b Created no TS -0.087000 -0.630000
hsa-miR-4271 aaagCTTCCCCCagcttaa
 2
 GGGGGAAG m8a Disrupted -0.291000 -0.282000 No effect
hsa-miR-4525 aaagctTCCCCCagcttaa
 2
 GGGGGGAU m6b Disrupted -0.060000 no TS 0.070000
hsa-miR-4665-5p aaagctTCCCCCAGcttaa
 2
 CUGGGGGA m8a Disrupted -0.133000 -0.076000 0.090000
hsa-miR-4725-3p aaagCTTCCCCcagcttaa
 2
 UGGGGAAG m7b Disrupted -0.251000 -0.261000 No effect
hsa-miR-4730 aaagctTCCGCCAGcttaa
 0 CUGGCGGA m8a Created no TS -0.142000 No effect
hsa-miR-4731-5p aaagcttcCCCCAGCttaa
 1
 UGCUGGGG m7b Disrupted -0.321000 -0.234000 0.070000
hsa-miR-5010-5p aaagctTCCCCCagcttaa
 2
 AGGGGGAU m6b Disrupted -0.049000 no TS No effect
hsa-miR-625-5p aaagcTTCCCCCagcttaa
 2
 AGGGGGAA m7b Disrupted -0.033000 no TS No effect
hsa-miR-637 aaagcttCCCCCAGcttaa
 2
 ACUGGGGG m7b Disrupted -0.099000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.2919119G>A COSN6119156 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4711-5p ccatttaCTGATGCggttg
 2
 UGCAUCAG m7b Disrupted -0.082000 no TS 0.090000
hsa-miR-545-5p ccaTTTACTGAtgcggttg
 3
 UCAGUAAA m8a Disrupted 0.075000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr18:g.2920282C>T COSN1204912 BN37T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-181a-2-3p gcggcaccTCAGTGGgtgg
 2
 ACCACUGA m7b Disrupted 0.000000 0.003000 No effect
hsa-miR-18a-5p gcgGCACCTTAgtgggtgg
 0 UAAGGUGC m8a Created 0.019000 0.038000 No effect
hsa-miR-18b-5p gcgGCACCTTAgtgggtgg
 0 UAAGGUGC m8a Created 0.019000 0.038000 No effect
hsa-miR-4301 gcggcacctTAGTGGGtgg
 0 UCCCACUA m7b (m6b->m7b) -0.126000 0.000000 No effect
hsa-miR-4735-3p gcgGCACCTTagtgggtgg
 0 AAAGGUGC m7b (m6c->m7b) 0.019000 0.038000 No effect
hsa-miR-181a-2-3p gcggcaccTCAGTGGgtgg
 2
 ACCACUGA m7b Disrupted 0.000000 0.003000 No effect
hsa-miR-18a-5p gcgGCACCTTAgtgggtgg
 0 UAAGGUGC m8a Created 0.019000 0.038000 No effect
hsa-miR-18b-5p gcgGCACCTTAgtgggtgg
 0 UAAGGUGC m8a Created 0.019000 0.038000 No effect
hsa-miR-4301 gcggcacctTAGTGGGtgg
 0 UCCCACUA m7b (m6b->m7b) -0.126000 0.000000 No effect
hsa-miR-4735-3p gcgGCACCTTagtgggtgg
 0 AAAGGUGC m7b (m6c->m7b) 0.019000 0.038000 No effect
hsa-miR-181a-2-3p gcggcaccTCAGTGGgtgg
 2
 ACCACUGA m7b Disrupted 0.000000 0.003000 No effect
hsa-miR-18a-5p gcgGCACCTTAgtgggtgg
 0 UAAGGUGC m8a Created 0.019000 0.038000 No effect
hsa-miR-18b-5p gcgGCACCTTAgtgggtgg
 0 UAAGGUGC m8a Created 0.019000 0.038000 No effect
hsa-miR-4301 gcggcacctTAGTGGGtgg
 0 UCCCACUA m7b (m6b->m7b) -0.126000 0.000000 No effect
hsa-miR-4735-3p gcgGCACCTTagtgggtgg
 0 AAAGGUGC m7b (m6c->m7b) 0.019000 0.038000 No effect
hsa-miR-181a-2-3p gcggcaccTCAGTGGgtgg
 0 ACCACUGA m7b Disrupted 0 0.003 No effect
hsa-miR-18a-5p gcgGCACCTTAgtgggtgg
 0 UAAGGUGC m8a Created 0.019 0.038 No effect
hsa-miR-18b-5p gcgGCACCTTAgtgggtgg
 0 UAAGGUGC m8a Created 0.019 0.038 No effect
hsa-miR-4301 gcggcacctTAGTGGGtgg
 0 UCCCACUA m7b (m6b->m7b) -0.126 0 No effect
hsa-miR-4735-3p gcgGCACCTTagtgggtgg
 0 AAAGGUGC m7b (m6c->m7b) 0.019 0.038 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
2919114 rs147362027 G
A hsa-miR-217
hsa-miR-4711-5p
hsa-miR-6807-3p
hsa-miR-7112-3p
2
2
2
2
 tgATGCAGTtgta
TGATGCAgttgta
tgATGCAGTtgta
TGATGCAgttgta
 Created
Created
Created
Created
N
N
N
N
 -0.017
-0.075
-0.017
-0.043
2919211 rs149858117 G G hsa-miR-423-3p
hsa-miR-4787-5p
2
1
 ccccCCGAGCAgt
cCCCCCGAgcagt
 Disrupted
Disrupted
N
N
 -0.108
-0.129
A hsa-miR-1275
hsa-miR-328-5p
hsa-miR-4665-5p
hsa-miR-6751-5p
hsa-miR-6795-5p
hsa-miR-6803-5p
hsa-miR-6885-5p
hsa-miR-6887-5p
hsa-miR-7109-5p
1
1
1
1
1
1
1
1
1
 cCCCCCAAgcagt
CCCCCCAagcagt
cCCCCCAAgcagt
cCCCCCAAgcagt
CCCCCCAagcagt
cCCCCCAAgcagt
CCCCCCAagcagt
CCCCCCAagcagt
CCCCCCAAgcagt
 Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
 -0.049
-0.166
-0.042
-0.048
-0.125
-0.055
-0.166
-0.125
-0.165

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