SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_153371
Gene Symbol: LNX2
Description: Homo sapiens ligand of numb-protein X 2 (LNX2), mRNA.
Gene Location: chr13(-):28120049-28194720
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr13:g.27545927T>C COSN15225193 LP6005334-DNA_E03 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-135a-5p aaataaAAGCCATcctttc
0 UAUGGCUU m7b Created no TS -0.272000 -0.080000
hsa-miR-135b-5p aaataaAAGCCATcctttc
0 UAUGGCUU m7b Created no TS -0.272000 -0.070000
hsa-miR-2392 aaataaaagCCATCCTttc
0 UAGGAUGG m7b (m6b->m7b) no TS -0.215000 No effect
hsa-miR-3119 aaatAAAAGCCAtcctttc
0 UGGCUUUU m8a Created -0.050000 -0.412000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr13:g.27545962A>G COSN7397364 8067246 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-302a-5p gatGTTTAAGTaatggtgt
0 ACUUAAAC m8a Created no TS -0.157000 -1.510000
hsa-miR-885-5p gatgtttaaGTAATGGtgt
0 UCCAUUAC m7b (m6b->m7b) no TS -0.255000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr13:g.27547490T>C COSN1605046 RK115_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-30b-3p tgtaatCTCCCAatattca
2
CUGGGAGG m6b Created -0.159000 -0.258000 -0.020000
hsa-miR-30c-1-3p tgtaaTCTCCCAatattca
1
CUGGGAGA m7b Created -0.103000 -0.379000 -0.010000
hsa-miR-30c-2-3p tgtaaTCTCCCAatattca
1
CUGGGAGA m7b Created -0.109000 -0.385000 No effect
hsa-miR-3689a-3p tgtaatCTCCCAatattca
2
CUGGGAGG m6b Created -0.169000 -0.268000 No effect
hsa-miR-3689b-3p tgtaatCTCCCAatattca
2
CUGGGAGG m6b Created -0.169000 -0.268000 No effect
hsa-miR-3689c tgtaatCTCCCAatattca
2
CUGGGAGG m6b Created -0.169000 -0.268000 No effect
hsa-miR-4461 tgtaatcTCTCAATattca
3
GAUUGAGA m7b Disrupted -0.141000 no TS 0.190000

Mutation Mutation ID Sample Name Cancer Type
chr13:g.27547655C>G COSN6225429 RK187_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-369-5p caggatggtGTCGATCTcc
0 AGAUCGAC m8a (m7a->m8a) no TS -0.183000 1.580000
hsa-miR-4786-5p caggaTGGTCTCgatctcc
2
UGAGACCA m7b Disrupted -0.119000 no TS 3.550000

Mutation Mutation ID Sample Name Cancer Type
chr13:g.27547729C>T ICGC_87A2B5E4-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1228-3p gactacAGGTGTGtgccac
0 UCACACCU m7b Created -0.326 -0.399 -0.01
hsa-miR-329 gactacaGGTGTGTgccac
0 AACACACC m7b Created no TS -0.078 -0.28
hsa-miR-362-3p gactacaGGTGTGTgccac
0 AACACACC m7b Created no TS -0.069 -0.01

Mutation Mutation ID Sample Name Cancer Type
chr13:g.27547749C>T ICGC_87A2BB70-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3664-3p tcagccTCCTGAGtagctg
0 UCUCAGGA m7b Created no TS -0.034 -1.58
hsa-miR-4433-3p tcagcCTCCTGagtagctg
0 ACAGGAGU m6b Created -0.023 -0.082 -11.12
hsa-miR-4459 tcagCCTCCTGagtagctg
0 CCAGGAGG m7b Created -0.076 -0.297 -2.03
hsa-miR-4695-5p tcaGCCTCCTGagtagctg
0 CAGGAGGC m8a Created -0.066 -0.215 -2.3
hsa-miR-4768-3p tcagcCTCCTGagtagctg
0 CCAGGAGA m6b Created -0.169 -0.201 -2.93
hsa-miR-510 tcagcctCCTGAGTAgctg
0 UACUCAGG m8a Created no TS -0.178 -1.52
hsa-miR-512-5p tcagcctcCTGAGTagctg
0 CACUCAGC m6b Created no TS -0.033 -6.72

Mutation Mutation ID Sample Name Cancer Type
chr13:g.27547788C>T COSN4705624 PD3851a [breast][NS][carcinoma][ductal_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1827 tgcaagctCTGCCTCctgg
0 UGAGGCAG m7b Created no TS -0.114000 -0.460000
hsa-miR-25-5p tgcaagCTCCGCCTcctgg
0 AGGCGGAG m8a Disrupted -0.202000 no TS -0.100000
hsa-miR-3612 tgcaagctcTGCCTCCTgg
0 AGGAGGCA m8a (m7a->m8a) no TS -0.108000 0.400000
hsa-miR-650 tgcaagctcTGCCTCCTgg
0 AGGAGGCA m8a (m7a->m8a) no TS -0.098000 -2.050000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
27547652 rs190662972 A G hsa-miR-4683
1
ggtctcGATCTCC
Created
N
-0.067
A hsa-miR-3672
hsa-miR-4461
hsa-miR-4786-5p
hsa-miR-5186
hsa-miR-6864-3p
hsa-miR-769-5p
1
1
1
1
1
1
gGTCTCAAtctcc
ggTCTCAATctcc
GGTCTCAatctcc
ggtctCAATCTCc
gGTCTCAAtctcc
GGTCTCAatctcc
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
-0.045
0.015
-0.13
-0.042
-0.045
-0.091

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