SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_014916 |
---|---|
Gene Symbol: | LMTK2 |
Description: | Homo sapiens lemur tyrosine kinase 2 (LMTK2), mRNA. |
Gene Location: | chr7(+):97736196-97838944 |
Browse Associations |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.98206520G>A | COSN8807484 | SS6003314 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4746-3p |
caccGCACCGCTtccctcc |
1 |
AGCGGUGC | m8a | Disrupted | -0.844000 | -0.743000 |
-0.740000 |
|
hsa-miR-4795-5p |
caccgcaCCACTTCcctcc |
3 |
AGAAGUGG | m7b | Created | 0.060000 | 0.124000 | No effect | |
hsa-miR-675-5p |
caCCGCACCActtccctcc |
2 |
UGGUGCGG | m8a | (m7a->m8a) | -0.116000 | -0.279000 |
-2.100000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.98206665C>T | COSN8049487 | 8034291 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-224-5p |
gggaccgttTGACTTGatg |
2 |
CAAGUCAC | m7a | (m6b->m7a) | -0.081000 | -0.081000 | No effect | |
hsa-miR-553 |
gggACCGTTTgacttgatg |
0 | AAAACGGU | m7b | (m6b->m7b) | no TS | 0.038000 |
-0.060000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.98206935C>T | COSN5229966 | SS6003302 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.98207192T>A | COSN9518132 | AOCS-106-1-1 | [ovary][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4282 |
cacccaacAAATTTTccgg |
0 | UAAAAUUU | m7b | Created | no TS | 0.336000 |
-0.090000 |
|
hsa-miR-4781-3p |
cacCCAACATattttccgg |
1 |
AAUGUUGG | m7b | (m7b->m6b) | 0.099000 | no TS |
0.170000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.98207264C>T | COSN1356056 | HCC33T | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3937 |
caggggCCGCCTGgggtac |
2 |
ACAGGCGG | m7b | Disrupted | -0.001000 | no TS |
2.360000 |
|
hsa-miR-3937 |
caggggCCGCCTGgggtac |
2 |
ACAGGCGG | m7b | Disrupted | -0.001000 | no TS |
2.360000 |
|
hsa-miR-3937 |
caggggCCGCCTGgggtac |
2 |
ACAGGCGG | m7b | Disrupted | -0.001 | no TS |
2.36 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.98207344C>T | COSN8049488 | 8015259 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3974 |
aaTGACCTTTattgccagt |
10 |
AAAGGUCA | m8a | (m7a->m8a) | 0.032000 | 0.005000 |
-0.250000 |
|
hsa-miR-493-3p |
aatGACCTTCAttgccagt |
3 |
UGAAGGUC | m8a | Disrupted | -0.047000 | no TS |
1.200000 |
|
hsa-miR-548m |
aatgACCTTTattgccagt |
0 | CAAAGGUA | m6b | Created | no TS | 0.079000 |
-0.200000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.98208246C>T | 9_30570 | CRC-4-Tumor | Colorectal adenocarcinoma | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1229 |
atggaggGGTGAGAtttta |
4 |
CUCUCACC | m7b | Created | no TS | -0.051 | No effect | |
hsa-miR-1285-5p |
atggagggGTGAGATttta |
4 |
GAUCUCAC | m7b | Created | 0.07 | 0.063 |
0.09 |
|
hsa-miR-4749-3p |
atgGAGGGGCGagatttta |
4 |
CGCCCCUC | m8a | Disrupted | -0.258 | -0.14 |
1.65 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.98208937G>T | COSN5105668 | HX27T | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr7:g.98208984G>C | COSN8049490 | 8034061 | [pancreas][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-4655-5p |
cagggCCCCGGTGgaagga |
2 |
CACCGGGG | m8a | Disrupted | -0.175000 | no TS |
0.760000 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
98205820 | rs140980138 | C | C |
hsa-miR-4746-3p hsa-miR-8064 |
1 1 |
tgtgtGCACCGCA tGTGTGCAccgca |
Disrupted Disrupted |
N N |
-0.509 -0.07 |
T |
hsa-miR-329-3p hsa-miR-362-3p hsa-miR-3941 hsa-miR-603 |
1 1 1 1 |
tGTGTGTAccgca tGTGTGTAccgca tGTGTGTAccgca tGTGTGTAccgca |
Created Created Created Created |
N N N N |
-0.022 -0.022 -0.011 -0.018 |
|||
98206495 | rs185085102 | T | T |
hsa-miR-1301-3p hsa-miR-3944-5p hsa-miR-4660 hsa-miR-5047 |
2 1 2 2 |
gagAGCTGCAccc gagaGCTGCACcc gaGAGCTGCAccc gagAGCTGCAccc |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
0.02 -0.04 -0.143 0.039 |
C |
hsa-miR-4466 hsa-miR-6741-3p hsa-miR-675-5p |
1 2 1 |
gagagCCGCACCc gAGAGCCGcaccc gagagCCGCACCc |
Created Created Created |
N N N |
-0.092 -0.047 -0.092 |
|||
98207262 | rs146744242 | C | C |
hsa-miR-3937 |
2 |
aggggCCGCCTGg |
Disrupted |
N |
-0.001 |
T |
hsa-miR-4514 hsa-miR-4645-5p hsa-miR-4673 hsa-miR-4692 hsa-miR-6769a-3p |
2 2 2 2 2 |
aggggCTGCCTGg aggggcTGCCTGG aggggcTGCCTGG aggggCTGCCTGg AGGGGCTgcctgg |
Created Created Created Created Created |
N N N N N |
0.123 0.124 0.097 0.132 0.053 |
|||
98207264 | rs35215639 | - | C |
hsa-miR-3937 |
2 |
gggCCGCCTGggg |
Unknown |
N |
-0.001 |
- | |||||||||
98207505 | rs200445166 | T | T |
hsa-miR-10a-3p |
2 |
cgCGAATTTtttt |
Disrupted |
N |
0.121 |
A |
hsa-miR-3606-3p hsa-miR-4282 hsa-miR-513a-3p hsa-miR-513c-3p |
2 2 2 2 |
cgcGAAATTTttt cgcgAAATTTTtt cgcGAAATTTttt cgcGAAATTTttt |
Created Created Created Created |
N N N N |
0.209 0.237 0.2 0.2 |
|||
98208120 | rs200702089 | - | C | 0 |
|
||||
- |
hsa-miR-4282 |
0 |
aaaaaAAATTTT |
Unknown |
N |
0.152 |
|||
98208120 | rs74617349 | - | |||||||
A |
hsa-miR-4282 |
0 |
aaaaaaAAATTTT |
Unknown |
N |
0.159 |
|||
98208246 | rs180844153 | C | C |
hsa-miR-4749-3p |
2 |
GAGGGGCgagatt |
Disrupted |
N |
-0.118 |
T |
hsa-miR-1229-3p hsa-miR-1285-5p hsa-miR-216a-5p hsa-miR-6511a-3p hsa-miR-6511b-3p hsa-miR-6784-3p hsa-miR-6802-3p hsa-miR-6862-3p |
2 2 2 2 2 2 2 2 |
gaggGGTGAGAtt gagggGTGAGATt gaggggTGAGATT gaggGGTGAGAtt gaggGGTGAGAtt gagGGGTGAGAtt gaGGGGTGAgatt gagGGGTGAGAtt |
Created Created Created Created Created Created Created Created |
N N N N N N N N |
-0.051 -0.007 0.047 -0.044 -0.044 -0.149 -0.116 -0.138 |
|||
98208984 | rs3735255 | G | G |
hsa-miR-181d-3p hsa-miR-4655-5p hsa-miR-6784-5p |
3 2 3 |
ggcCCCGGTGgaa ggCCCCGGTggaa gGCCCCGGtggaa |
Disrupted Disrupted Disrupted |
N N N |
-0.145 -0.175 -0.208 |
A |
hsa-miR-1227-5p hsa-miR-1273g-3p hsa-miR-128-1-5p hsa-miR-128-2-5p hsa-miR-181a-2-3p hsa-miR-4436b-5p hsa-miR-6509-3p hsa-miR-6762-5p hsa-miR-6845-5p |
3 3 3 3 3 15 2 3 3 |
GGCCCCAgtggaa ggcccCAGTGGAa GGCCCCAgtggaa GGCCCCAgtggaa ggcccCAGTGGAa ggccccAGTGGAA ggcccCAGTGGAA GGCCCCAgtggaa GGCCCCAgtggaa |
Created Created Created Created Created Created Created Created Created |
N N N N N N N N N |
-0.131 -0.013 -0.157 -0.157 -0.031 -0.013 -0.101 -0.153 -0.146 |
|||
98209147 | rs116450388 | G | G |
hsa-miR-224-5p hsa-miR-6890-3p |
2 1 |
cgcaGTGACTTcc cGCAGTGActtcc |
Disrupted Disrupted |
N N |
-0.081 -0.115 |
A |
hsa-miR-4670-3p |
3 |
cgcagTAACTTCc |
Created |
N |
-0.018 |