SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001004317
Gene Symbol: LIN28B
Description: Homo sapiens lin-28 homolog B (C. elegans) (LIN28B), mRNA.
Gene Location: chr6(+):105404922-105531206
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr6:g.105078816G>A COSN6719530 RK119_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-891b cctttacccAGTTGCAaag
 0 UGCAACUU m7a (m6b->m7a) no TS -0.144000 -0.290000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.105079195T>C COSN2132326 RK027_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4738-3p agatAGTTTCAaatttaac
 0 UGAAACUG m7a Created 0.047000 -0.006000 No effect
hsa-miR-548a-3p agatAGTTTTaaatttaac
 2
 CAAAACUG m6b Disrupted 0.088000 0.079000 No effect
hsa-miR-548ar-3p agatAGTTTTAaatttaac
 2
 UAAAACUG m7a Disrupted 0.071000 0.069000 0.130000
hsa-miR-548e agatAGTTTTaaatttaac
 2
 AAAAACUG m6b Disrupted 0.096000 0.090000 -0.020000
hsa-miR-548f agatAGTTTTaaatttaac
 2
 AAAAACUG m6b Disrupted 0.099000 0.090000 0.380000
hsa-miR-5582-3p agatAGTTTTAaatttaac
 2
 UAAAACUU m7a Disrupted 0.119000 0.113000 0.010000
hsa-miR-4738-3p agatAGTTTCAaatttaac
 0 UGAAACUG m7a Created 0.047 -0.006 No effect
hsa-miR-548a-3p agatAGTTTTaaatttaac
 2
 CAAAACUG m6b Disrupted 0.088 0.079 No effect
hsa-miR-548ar-3p agatAGTTTTAaatttaac
 2
 UAAAACUG m7a Disrupted 0.071 0.069 0.13
hsa-miR-548e agatAGTTTTaaatttaac
 2
 AAAAACUG m6b Disrupted 0.096 0.09 -0.02
hsa-miR-548f agatAGTTTTaaatttaac
 2
 AAAAACUG m6b Disrupted 0.099 0.09 0.38
hsa-miR-5582-3p agatAGTTTTAaatttaac
 2
 UAAAACUU m7a Disrupted 0.119 0.113 0.01

Mutation Mutation ID Sample Name Cancer Type
chr6:g.105079351C>G COSN8493390 J88_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-146a-5p tccAGTTCTCccgaatttg
 8
 UGAGAACU m7b (m7b->m6b) -0.045000 no TS 0.300000
hsa-miR-146b-5p tccAGTTCTCccgaatttg
 8
 UGAGAACU m7b (m7b->m6b) -0.045000 no TS 1.030000
hsa-miR-425-3p tccagttcTCCCGAatttg
 0 AUCGGGAA m6b Disrupted -0.229000 no TS 0.720000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.105079874G>A COSN9289104 AOCS-057-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3925-3p aaatACTGGAGTtgagaat
 2
 ACUCCAGU m8a Created -0.254000 -0.430000 -2.060000
hsa-miR-508-5p aaataCTGGAGTtgagaat
 0 UACUCCAG m7b Created -0.518000 -0.676000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.105080182T>C COSN5617012 RK155_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3918 tagtattGGCCCTGTtagg
 7
 ACAGGGCC m8a Created -0.009000 -0.196000 No effect
hsa-miR-4700-3p tagtattgGTCCTGTtagg
 3
 CACAGGAC m7b Disrupted 0.016000 0.049000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.105080448G>T COSN2132327 RK167_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-3p atgggagacTTGTATAGtt
 0 CUAUACAA m8a (m7b->m8a) no TS 0.198000 No effect
hsa-let-7b-3p atgggagacTTGTATAGtt
 0 CUAUACAA m8a (m7b->m8a) no TS 0.198000 No effect
hsa-let-7f-1-3p atgggagacTTGTATAGtt
 0 CUAUACAA m8a (m7b->m8a) no TS 0.207000 No effect
hsa-miR-300 atgggagaCTTGTATAgtt
 0 UAUACAAG m8a Created no TS 0.191000 -0.010000
hsa-miR-3184-3p atggGAGACTTgtatagtt
 0 AAAGUCUC m7b Created no TS 0.092000 -0.020000
hsa-miR-381 atgggagaCTTGTATAgtt
 0 UAUACAAG m8a Created no TS 0.212000 No effect
hsa-miR-4666a-3p atgggagacTTGTATagtt
 0 CAUACAAU m6b Created no TS 0.148000 -0.010000
hsa-miR-4789-5p atgggagacGTGTATAgtt
 2
 GUAUACAC m7b (m7b->m6c) -0.043000 -0.177000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.105080561C>A COSN8493391 227_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1255b-2-3p gagaatctgAGTGGTatac
 0 AACCACUU m6b Created no TS -0.020000 No effect
hsa-miR-4330 gagaATCTGAGtggtatac
 0 CCUCAGAU m7b Created no TS 0.056000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.105081047T>C COSN14760642 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4426 taccaaacCCATCTTatgg
 8
 GAAGAUGG m7b Created 0.111000 0.184000 -0.130000
hsa-miR-4464 tacCAAACCTatcttatgg
 10
 AAGGUUUG m7b (m7b->m6b) 0.100000 0.062000 2.110000
hsa-miR-4647 taccaaacCCATCTTatgg
 8
 GAAGAUGG m7b Created 0.128000 0.159000 -0.310000
hsa-miR-4662a-3p taccaaacCTATCTTatgg
 8
 AAAGAUAG m7b Disrupted 0.072000 no TS 0.130000
hsa-miR-4662b taccaaacCCATCTTatgg
 8
 AAAGAUGG m7b Created 0.125000 0.146000 No effect
hsa-miR-4748 tacCAAACCTatcttatgg
 10
 GAGGUUUG m7b (m7b->m6b) 0.151000 0.081000 0.560000
hsa-miR-5087 tacCAAACCCatcttatgg
 10
 GGGUUUGU m7a (m6a->m7a) -0.008000 -0.008000 0.020000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.105082102C>A COSN8791878 SS6003111 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-346 gctacatGGCAGACtataa
 2
 UGUCUGCC m7b Disrupted -0.190000 no TS No effect
hsa-miR-4659a-5p gctaCATGGCAGactataa
 5
 CUGCCAUG m8a Disrupted -0.113000 no TS 0.310000
hsa-miR-4659b-5p gctaCATGGCAgactataa
 5
 UUGCCAUG m7b Disrupted -0.113000 no TS 0.450000
hsa-miR-4716-5p gctACATGGAagactataa
 0 UCCAUGUU m7a (m6a->m7a) no TS 0.011000 No effect
hsa-miR-4727-5p gctacaTGGCAGActataa
 7
 AUCUGCCA m7b Disrupted -0.104000 no TS 2.240000
hsa-miR-4769-3p gctacATGGCAGActataa
 5
 UCUGCCAU m8a Disrupted -0.061000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.105082164T>C COSN7592667 8012342 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-324-5p ccttGGATGCatttttgca
 0 CGCAUCCC m6b Created no TS -0.082000 -1.050000
hsa-miR-5700 ccttggATGCATTtttgca
 3
 UAAUGCAU m7b Created 0.076000 0.137000 0.040000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.105082320T>G COSN9963178 C0007T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-19a-3p cagttttatTTTGCACcag
 14
 UGUGCAAA m7b (m7b->m6c) -0.062000 no TS 0.620000
hsa-miR-19b-3p cagttttatTTTGCACcag
 14
 UGUGCAAA m7b (m7b->m6c) -0.062000 no TS -0.530000
hsa-miR-4803 cagttTTATGTTgcaccag
 5
 UAACAUAA m7b Created -0.178000 -0.081000 -0.040000
hsa-miR-548aw cagttttaTTTTGCACcag
 14
 GUGCAAAA m8a Disrupted 0.034000 -0.008000 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.105082460A>G COSN8493392 381_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3129-3p ttaaagTTAGTTTaaatta
 9
 AAACUAAU m7a Created 0.119000 0.119000 -0.040000
hsa-miR-4637 ttaaAGTTAGTttaaatta
 0 UACUAACU m7b Created no TS -0.166000 -2.180000
hsa-miR-5583-5p ttaaagTTAGTTTaaatta
 9
 AAACUAAU m7a Created 0.119000 0.119000 -3.120000


Mutation Mutation ID Sample Name Cancer Type
chr6:g.105082943G>T COSN9289105 AOCS-084-1-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr6:g.105083063C>T COSN9289106 AOCS-133-1-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7d-5p ttagatTACCTCattgtcc
 11
 AGAGGUAG m6b Disrupted -0.985000 -0.837000 0.180000
hsa-miR-202-3p ttagatTACCTCattgtcc
 11
 AGAGGUAU m6b Disrupted -0.332000 -0.169000 2.740000
hsa-miR-4458 ttagatTACCTCattgtcc
 11
 AGAGGUAG m6b Disrupted -0.842000 -0.687000 0.040000
hsa-miR-548ao-5p ttagaTTACTTCattgtcc
 13
 AGAAGUAA m7b Created -0.030000 -0.282000 -0.200000
hsa-miR-548ax ttagaTTACTTCattgtcc
 13
 AGAAGUAA m7b Created -0.030000 -0.271000 -1.410000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.105083081T>A COSN7592668 8061178 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-592 catttTGACACAtgttgtt
 2
 UUGUGUCA m7b Created -0.043000 -0.292000 -3.060000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
105079290 rs150421099 T T hsa-miR-362-5p
hsa-miR-500b-5p
hsa-miR-501-5p
hsa-miR-548ao-5p
hsa-miR-548ax
hsa-miR-5585-5p
11
11
11
17
17
17
 aAAGGATActtca
aAAGGATActtca
AAAGGATActtca
aaaggaTACTTCA
aaaggaTACTTCA
aaaggaTACTTCA
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 -0.024
-0.024
-0.071
-0.03
-0.03
-0.023
C hsa-miR-3616-5p
hsa-miR-4795-5p
hsa-miR-573
15
17
17
 aaaggaCACTTCA
aaaggaCACTTCA
aaaggaCACTTCA
 Created
Created
Created
N
N
N
 -0.096
-0.031
-0.087
105079353 rs183025644 C C hsa-miR-10a-3p
hsa-miR-425-3p
hsa-miR-6746-5p
hsa-miR-6771-5p
hsa-miR-6878-5p
5
4
4
4
9
 ttctccCGAATTT
ttcTCCCGAAttt
tTCTCCCGAattt
ttCTCCCGAAttt
TTCTCCCgaattt
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 0.042
-0.229
-0.421
-0.476
-0.109
T hsa-miR-4433-3p
hsa-miR-4459
hsa-miR-4768-3p
hsa-miR-506-5p
4
4
4
4
 ttCTCCTGAattt
ttCTCCTGAattt
tTCTCCTGAattt
ttctCCTGAATtt
 Created
Created
Created
Created
N
N
N
N
 -0.099
-0.09
-0.25
-0.117
105081662 rs191808032 A A hsa-miR-371b-3p
hsa-miR-4641
10
13
 atGGGCACTgttc
ATGGGCActgttc
 Disrupted
Disrupted
N
N
 -0.175
-0.07
C hsa-miR-3918
hsa-miR-7160-3p
3
10
 atgGGCCCTGttc
atGGGCCCTgttc
 Created
Created
N
N
 -0.117
-0.233
105082255 rs55848449 C
T hsa-miR-3143
hsa-miR-4803
hsa-miR-543
3
6
3
 aAATGTTAtgtta
aaatgTTATGTTA
aAATGTTAtgtta
 Created
Created
Created
N
N
N
 0.033
0.088
0.084

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