SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001198689
Gene Symbol: LEPR
Description: Homo sapiens leptin receptor (LEPR), transcript variant 3, mRNA.
Gene Location: chr1(+):65991371-66101111
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Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr1:g.65633330C>A COSN6464354 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-148a-5p gatttAGAACTTaaaatag
 6
 AAAGUUCU m7b Disrupted -0.342000 -0.013000 0.460000
hsa-miR-148b-5p gatttAGAACTTaaaatag
 2
 AAGUUCUG m7a Disrupted -0.089000 -0.089000 0.010000
hsa-miR-3168 gattTAGAACTtaaaatag
 7
 GAGUUCUA m7b Disrupted -0.243000 no TS 0.630000
hsa-miR-4775 gatttagAAATTAAaatag
 1
 UUAAUUUU m7a Created 0.055000 0.084000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65633492T>G 9_10816 CRC-3-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1226-3p ttatgGCTGGTGctgtcat
 17
 UCACCAGC m7b Created no TS -0.244 -5.62
hsa-miR-29a-3p ttatggcTGGTGCTgtcat
 16
 UAGCACCA m7b Created no TS -0.208 -3.67
hsa-miR-29b-3p ttatggcTGGTGCTgtcat
 16
 UAGCACCA m7b Created no TS -0.208 -3.672
hsa-miR-29c-3p ttatggcTGGTGCTgtcat
 16
 UAGCACCA m7b Created no TS -0.208 -3.48
hsa-miR-3065-3p ttatggctGGTGCTGtcat
 12
 UCAGCACC m7b Created no TS -0.278 -5.04

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65633614G>T COSN6041606 RK191_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-145-3p ataagtatGGAATCagtga
 0 GGAUUCCU m6b Disrupted -0.134000 no TS 0.710000
hsa-miR-3920 ataagtatgTAATCAGTga
 0 ACUGAUUA m8a (m7b->m8a) no TS -0.142000 -0.450000
hsa-miR-587 ataagTATGGAAtcagtga
 1
 UUUCCAUA m7b Disrupted -0.266000 -0.157000 1.910000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65633655T>G COSN8913963 SS6003121 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4261 tgtccaaacGTTTCCattt
 0 AGGAAACA m6b Created no TS -0.097000 -0.140000
hsa-miR-561-3p tgtccAAACTTTtccattt
 1
 CAAAGUUU m7b Disrupted 0.029000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65633755C>G COSN6464355 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-10b-3p aactttgttGAATCTGgga
 3
 ACAGAUUC m7b (m6c->m7b) -0.103000 -0.238000 -3.000000
hsa-miR-3065-5p aacTTTGTTGAatctggga
 0 UCAACAAA m8a Created no TS -0.079000 -2.820000
hsa-miR-421 aacttTGTTGAatctggga
 0 AUCAACAG m6b Created no TS -0.040000 -0.880000
hsa-miR-4272 aactttGTTGAATctggga
 0 CAUUCAAC m7b Created 0.030000 -0.052000 -1.190000
hsa-miR-7-1-3p aacTTTGTTGaatctggga
 1
 CAACAAAU m7a (m6a->m7a) -0.047000 -0.047000 0.040000
hsa-miR-7-2-3p aacTTTGTTGaatctggga
 1
 CAACAAAU m7a (m6a->m7a) -0.056000 -0.056000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65634137G>A COSN8143069 PCSI_0312_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-147a tcagCACACAaattatgct
 0 GUGUGUGG m6b Created no TS -0.052000 No effect
hsa-miR-5010-3p tcagcACACAAAttatgct
 0 UUUUGUGU m7b Created no TS -0.000000 -0.280000
hsa-miR-599 tcagcACACAAattatgct
 0 GUUGUGUC m6b Created no TS 0.001000 -0.070000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65634148C>T COSN6464356 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-103a-3p attATGCTGCgttgctcac
 0 AGCAGCAU m7b (m7b->m6b) -0.105000 no TS 0.170000
hsa-miR-107 attATGCTGCgttgctcac
 0 AGCAGCAU m7b (m7b->m6b) -0.105000 no TS 0.240000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65634767G>A COSN6464357 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
65633330 rs17415296 C C hsa-miR-148a-5p
hsa-miR-3168
hsa-miR-7856-5p
6
7
13
 ttAGAACTTAaaa
tTAGAACTtaaaa
ttagaaCTTAAAA
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.329
-0.243
-0.012
A hsa-miR-4263
hsa-miR-4775
hsa-miR-576-5p
7
7
7
 TTAGAAAttaaaa
ttagAAATTAAaa
TTAGAAAttaaaa
 Created
Created
Created
N
N
N
 -0.041
0.029
-0.05
65633755 rs3206172 C
G hsa-miR-10b-3p
hsa-miR-3065-5p
hsa-miR-421
hsa-miR-4272
hsa-miR-7159-5p
5
1
0
0
0
 tttgttGAATCTG
TTTGTTGAatctg
ttTGTTGAAtctg
tttGTTGAATctg
tTTGTTGAAtctg
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.135
-0.079
-0.04
-0.082
-0.16
65634082 rs146805288 C C hsa-miR-148b-5p
hsa-miR-3909
hsa-miR-4743-3p
hsa-miR-6852-3p
hsa-miR-6874-3p
hsa-miR-6888-3p
2
7
3
7
2
3
 tgaggaCAGAACT
tGAGGACAgaact
tgagGACAGAAct
tGAGGACAgaact
tgaggaCAGAACT
tgagGACAGAAct
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 -0.089
-0.077
-0.014
-0.074
-0.07
-0.032
T hsa-miR-3168
2
 tgaggaTAGAACT
 Created
N
 -0.062
65634148 rs12034502 T C hsa-miR-103a-3p
hsa-miR-107
0 ATGCTGCgttgct
ATGCTGCgttgct
 Created
Created
N
N
 -0.105
-0.105

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