SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001003679
Gene Symbol: LEPR
Description: Homo sapiens leptin receptor (LEPR), transcript variant 3, mRNA.
Gene Location: chr1(+):65886334-66101111
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Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr1:g.65633330C>A COSN6464354 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-148a-5p gatttAGAACTTaaaatag
 6
 AAAGUUCU m7b Disrupted -0.342000 -0.013000 0.460000
hsa-miR-148b-5p gatttAGAACTTaaaatag
 2
 AAGUUCUG m7a Disrupted -0.089000 -0.089000 0.010000
hsa-miR-3168 gattTAGAACTtaaaatag
 7
 GAGUUCUA m7b Disrupted -0.243000 no TS 0.630000
hsa-miR-4775 gatttagAAATTAAaatag
 1
 UUAAUUUU m7a Created 0.055000 0.084000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65633492T>G 9_10816 CRC-3-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1226-3p ttatgGCTGGTGctgtcat
 17
 UCACCAGC m7b Created no TS -0.244 -5.62
hsa-miR-29a-3p ttatggcTGGTGCTgtcat
 16
 UAGCACCA m7b Created no TS -0.208 -3.67
hsa-miR-29b-3p ttatggcTGGTGCTgtcat
 16
 UAGCACCA m7b Created no TS -0.208 -3.672
hsa-miR-29c-3p ttatggcTGGTGCTgtcat
 16
 UAGCACCA m7b Created no TS -0.208 -3.48
hsa-miR-3065-3p ttatggctGGTGCTGtcat
 12
 UCAGCACC m7b Created no TS -0.278 -5.04

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65633614G>T COSN6041606 RK191_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-145-3p ataagtatGGAATCagtga
 0 GGAUUCCU m6b Disrupted -0.134000 no TS 0.710000
hsa-miR-3920 ataagtatgTAATCAGTga
 0 ACUGAUUA m8a (m7b->m8a) no TS -0.142000 -0.450000
hsa-miR-587 ataagTATGGAAtcagtga
 1
 UUUCCAUA m7b Disrupted -0.266000 -0.157000 1.910000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65633655T>G COSN8913963 SS6003121 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4261 tgtccaaacGTTTCCattt
 0 AGGAAACA m6b Created no TS -0.097000 -0.140000
hsa-miR-561-3p tgtccAAACTTTtccattt
 1
 CAAAGUUU m7b Disrupted 0.029000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65633755C>G COSN6464355 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-10b-3p aactttgttGAATCTGgga
 3
 ACAGAUUC m7b (m6c->m7b) -0.103000 -0.238000 -3.000000
hsa-miR-3065-5p aacTTTGTTGAatctggga
 0 UCAACAAA m8a Created no TS -0.079000 -2.820000
hsa-miR-421 aacttTGTTGAatctggga
 0 AUCAACAG m6b Created no TS -0.040000 -0.880000
hsa-miR-4272 aactttGTTGAATctggga
 0 CAUUCAAC m7b Created 0.030000 -0.052000 -1.190000
hsa-miR-7-1-3p aacTTTGTTGaatctggga
 1
 CAACAAAU m7a (m6a->m7a) -0.047000 -0.047000 0.040000
hsa-miR-7-2-3p aacTTTGTTGaatctggga
 1
 CAACAAAU m7a (m6a->m7a) -0.056000 -0.056000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65634137G>A COSN8143069 PCSI_0312_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-147a tcagCACACAaattatgct
 0 GUGUGUGG m6b Created no TS -0.052000 No effect
hsa-miR-5010-3p tcagcACACAAAttatgct
 0 UUUUGUGU m7b Created no TS -0.000000 -0.280000
hsa-miR-599 tcagcACACAAattatgct
 0 GUUGUGUC m6b Created no TS 0.001000 -0.070000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65634148C>T COSN6464356 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-103a-3p attATGCTGCgttgctcac
 0 AGCAGCAU m7b (m7b->m6b) -0.105000 no TS 0.170000
hsa-miR-107 attATGCTGCgttgctcac
 0 AGCAGCAU m7b (m7b->m6b) -0.105000 no TS 0.240000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.65634767G>A COSN6464357 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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