SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_000230
Gene Symbol:	LEP
Description:	Homo sapiens leptin (LEP), mRNA.
Gene Location:	chr7(+):127881330-127897682
Browse Associations
Browse Pathways

Mutation			Mutation ID		Sample Name		Cancer Type
chr7:g.128255161A>T			COSN9922668		C0062T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-148b-5p	gacCAGAACTaggttccct	0	AAGUUCUG	m7b	(m6b->m7b)	no TS	-0.146000	-4.190000
hsa-miR-3168	gaccAGAACTaggttccct	0	GAGUUCUA	m6b	Created	no TS	-0.027000	-0.270000
hsa-miR-4273	gaccAGAACAaggttccct	2	GUGUUCUC	m6b	Disrupted	-0.004000	no TS	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr7:g.128255211A>T			COSN9828414		AOCS-139-1-5		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-147a	catCCACACACgcaggaac	3	GUGUGUGG	m8a	Disrupted	-0.148000	no TS	0.820000
hsa-miR-3193	catccacacACGCAGGAac	1	UCCUGCGU	m8a	(m8a->m7b)	-0.398000	-0.190000	0.050000
hsa-miR-3911	caTCCACACAcgcaggaac	3	UGUGUGGA	m8a	(m8a->m7a)	-0.269000	-0.143000	0.060000
hsa-miR-4520a-5p	catccacaCACGCAGGaac	1	CCUGCGUG	m8a	Disrupted	-0.241000	no TS	0.060000
hsa-miR-4520b-5p	catccacaCACGCAGGaac	1	CCUGCGUG	m8a	Disrupted	-0.241000	no TS	0.060000
hsa-miR-574-5p	catcCACACTCgcaggaac	0	UGAGUGUG	m7b	Created	-0.051000	-0.178000	4.460000

Mutation			Mutation ID		Sample Name		Cancer Type
chr7:g.128255611G>A			COSN6350650		RK128_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-543	gtgggGAATGTTTgggcag	0	AAACAUUC	m8a	Disrupted	0.140000	no TS	0.470000

Mutation			Mutation ID		Sample Name		Cancer Type
chr7:g.128255860G>A			9_114276		CRC-9-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5010-3p	gaataaaACACAAAgggct	0	UUUUGUGU	m7b	Created	-0.146	-0.138	-0.16
hsa-miR-599	gaataaaACACAAagggct	0	GUUGUGUC	m6b	Created	-0.076	-0.045	-0.08

Mutation			Mutation ID		Sample Name		Cancer Type
chr7:g.128256383G>T			COSN7959423		8032817		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-16-1-3p	taactttAATACTGagcac	0	CCAGUAUU	m7b	Created	no TS	0.034000	-5.090000
hsa-miR-302a-5p	taacTTTAAGactgagcac	8	ACUUAAAC	m6b	Disrupted	0.136000	no TS	0.010000
hsa-miR-4264	taactttaaGACTGAGcac	0	ACUCAGUC	m7b	(m7b->m6c)	-0.133000	-0.083000	0.290000
hsa-miR-4797-3p	taactttaaTACTGAGcac	0	UCUCAGUA	m7b	(m6c->m7b)	-0.079000	-0.110000	-0.110000
hsa-miR-622	taactttaAGACTGagcac	9	ACAGUCUG	m6b	Disrupted	0.010000	no TS	0.100000

Mutation			Mutation ID		Sample Name		Cancer Type
chr7:g.128257412C>T			ICGC_A3322F1A-2A78-11E2-8335-12FD496BB9B8		CPCG_0102_Pr_P_P2		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2113	tactaaaaaCACAAAagtt	0	AUUUGUGC	m6b	Disrupted	-0.01	0.02	No effect
hsa-miR-3149	tactaaaaATACAAAagtt	0	UUUGUAUG	m7a	Created	no TS	-0.015	-0.05
hsa-miR-5010-3p	tactaaaaACACAAAAgtt	0	UUUUGUGU	m8a	Disrupted	-0.147	0.03	0.4
hsa-miR-599	tactaaaaACACAAaagtt	0	GUUGUGUC	m6b	Disrupted	-0.076	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr7:g.128257457C>T			ICGC_A33233FC-2A78-11E2-8335-12FD496BB9B8		CPCG_0102_Pr_P_P2		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3652	agtcCCAGCCactcgggag	1	CGGCUGGA	m6b	Disrupted	-0.126	no TS	No effect
hsa-miR-4430	agtcCCAGCCactcgggag	1	AGGCUGGA	m6b	Disrupted	-0.126	no TS	No effect
hsa-miR-4505	agtCCCAGCCactcgggag	1	AGGCUGGG	m7b	(m7b->m6b)	-0.376	no TS	No effect
hsa-miR-5589-5p	agtCCCAGCCactcgggag	0	GGCUGGGU	m7a	(m7a->m6a)	-0.552	-0.552	No effect

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
128254869	rs200618442	G	G	hsa-miR-3690 hsa-miR-4254 hsa-miR-6838-3p	5 5 5	aTCCAGGActctg aTCCAGGActctg atcCAGGACTctg	Disrupted Disrupted Disrupted	N N N	-0.145 -0.141 -0.175
128254869	rs200618442	G	A	hsa-miR-1299 hsa-miR-148b-5p hsa-miR-378j hsa-miR-4782-5p hsa-miR-516b-5p hsa-miR-5706 hsa-miR-6839-5p hsa-miR-6874-3p	5 5 5 4 5 4 5 5	aTCCAGAActctg atcCAGAACTctg ATCCAGAactctg ATCCAGAActctg aTCCAGAActctg ATCCAGAActctg ATCCAGAactctg atcCAGAACTctg	Created Created Created Created Created Created Created Created	N N N N N N N N	-0.119 -0.121 -0.116 -0.306 -0.109 -0.306 -0.11 -0.112
128254992	rs28954116	C	C	hsa-miR-1293 hsa-miR-363-5p hsa-miR-4483 hsa-miR-4731-5p hsa-miR-4800-5p hsa-miR-5589-5p hsa-miR-6745 hsa-miR-6756-5p hsa-miR-6766-5p hsa-miR-6776-5p hsa-miR-8071	3 3 3 4 1 3 3 3 3 3 1	ggtCCACCCAgca ggTCCACCCAgca ggtCCACCCAgca ggtccaCCCAGCA GGTCCACccagca ggtccACCCAGCA ggTCCACCCAgca ggtCCACCCAgca ggtCCACCCAgca ggtcCACCCAGca gGTCCACCcagca	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N	-0.127 -0.287 -0.13 -0.114 -0.159 -0.292 -0.318 -0.107 -0.107 -0.114 -0.158
128254992	rs28954116	C	G	hsa-miR-3064-5p hsa-miR-3652 hsa-miR-4430 hsa-miR-4505 hsa-miR-5580-5p hsa-miR-5787 hsa-miR-6504-5p hsa-miR-6842-3p	3 3 3 3 3 3 3 3	ggtcCAGCCAGca ggTCCAGCCAgca ggTCCAGCCAgca ggtCCAGCCAgca ggtccAGCCAGCA ggtCCAGCCAgca ggtcCAGCCAGca ggtCCAGCCAgca	Created Created Created Created Created Created Created Created	N N N N N N N N	-0.101 -0.248 -0.248 -0.095 -0.318 -0.099 -0.101 -0.163
128255157	rs201995159	G	G	hsa-miR-3663-5p hsa-miR-4273 hsa-miR-4677-5p hsa-miR-6739-3p hsa-miR-7152-3p hsa-miR-7156-5p	2 2 2 2 2 2	tGACCAGAacaag tgaccAGAACAAg tgaccAGAACAAg tgaccAGAACAAg tGACCAGAacaag tgaccAGAACAAg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.107 -0.004 -0.006 0.017 -0.127 -0.007
128255157	rs201995159	G	A	hsa-miR-133a-3p hsa-miR-133b hsa-miR-19a-5p hsa-miR-19b-1-5p hsa-miR-19b-2-5p hsa-miR-2052 hsa-miR-5587-5p	2 2 2 2 2 2 1	tGACCAAAacaag tGACCAAAacaag tgacCAAAACAag tgacCAAAACAag tgacCAAAACAag tgacCAAAACAag TGACCAAaacaag	Created Created Created Created Created Created Created	N N N N N N N	-0.097 -0.097 0.016 0.016 0.016 0.017 -0.094
128255212	rs200166765	C	C	hsa-miR-1539 hsa-miR-3193 hsa-miR-4520a-5p hsa-miR-4520b-5p hsa-miR-6867-5p	1 1 1 1 3	cacacaCGCAGGA cacacACGCAGGA cacaCACGCAGga cacaCACGCAGga CACACACgcagga	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.194 -0.398 -0.241 -0.241 -0.056
128255212	rs200166765	C	T	hsa-miR-4666b	1	cacACATGCAgga	Created	N	-0.076
128255610	rs202039764	T	T	hsa-miR-543	2	gggGAATGTTtgg	Disrupted	N	0.14
128255610	rs202039764	T	G	hsa-miR-6734-3p	1	gGGGAAGGtttgg	Created	N	-0.055
128256387	rs201769388	G	G	hsa-miR-3907 hsa-miR-3934-3p hsa-miR-4264 hsa-miR-622	7 8 9 9	aagactGAGCACC aagaCTGAGCAcc aaGACTGAGcacc aAGACTGAgcacc	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.109 -0.002 -0.05 0.01
128256387	rs201769388	G	A	hsa-miR-4474-5p	9	aAGACTAAgcacc	Created	N	0.023
128256501	rs201949587	G	G	hsa-miR-1909-5p	1	caaaccGCACTCA	Disrupted	N	-0.044
128256501	rs201949587	G	A	hsa-miR-1273g-5p hsa-miR-3659 hsa-miR-4658 hsa-miR-5087 hsa-miR-574-5p hsa-miR-6790-5p	1 1 1 1 1 1	caAACCACActca caaaccACACTCA caaaccACACTCA CAAACCAcactca caaacCACACTCA caaaccACACTCA	Created Created Created Created Created Created	N N N N N N	0.023 0.004 0.045 0.05 -0.055 0.017
128256713	rs200171215	G	G	hsa-miR-10a-3p hsa-miR-4264 hsa-miR-4797-3p hsa-miR-5571-5p	21 3 3 4	aactgaGAATTTA aACTGAGAattta aACTGAGAattta aactGAGAATTta	Disrupted Disrupted Disrupted Disrupted	N N N N	0.037 -0.083 -0.079 -0.056
128256713	rs200171215	G	T	hsa-miR-361-5p hsa-miR-374a-3p hsa-miR-5094	4 4 3	aaCTGATAAttta aaCTGATAAttta aACTGATAattta	Created Created Created	N N N	-0.051 -0.128 -0.066
128257193	rs192232228	A	A	hsa-miR-2113 hsa-miR-5010-3p hsa-miR-758-3p	7 7 7	ttgctCACAAAAc ttgctCACAAAAc ttgcTCACAAAac	Disrupted Disrupted Disrupted	N N N	0.02 0.03 -0.037
128257193	rs192232228	A	T	hsa-miR-2052 hsa-miR-8055	20 7	ttgctcTCAAAAC ttgctCTCAAAAc	Created Created	N N	0.025 0.02
128257412	rs201995058	C	C	hsa-miR-2113 hsa-miR-5010-3p hsa-miR-599	1 1 1	taaaaaCACAAAA taaaaACACAAAA taaaaACACAAAa	Disrupted Disrupted Disrupted	N N N	-0.03 -0.177 -0.076
128257412	rs201995058	C	T	hsa-miR-3149	1	taaaaATACAAAa	Created	N	-0.015
128257457	rs200071518	C	C	hsa-miR-3652 hsa-miR-4430 hsa-miR-4505 hsa-miR-5787 hsa-miR-6842-3p	1 1 1 1 1	cCCAGCCActcgg cCCAGCCActcgg CCCAGCCActcgg CCCAGCCActcgg cCCAGCCActcgg	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.126 -0.126 -0.376 -0.376 -0.12
128257457	rs200071518	C

**Genome Browser**
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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

Genome Browser