SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_004985
Gene Symbol: KRAS
Description: Homo sapiens v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), transcript variant b, mRNA.
Gene Location: chr12(-):25358179-25403854
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr12:g.25205299C>T COSN7613478 PCSI_0023_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1206 tatttttgtCATGAACtgt
 16
 UGUUCAUG m7b (m7b->m6b) -0.231000 no TS -0.090000
hsa-miR-433 tatttttgTCATGAactgt
 16
 AUCAUGAU m6b Disrupted -0.053000 0.056000 0.060000
hsa-miR-495 tattTTTGTTatgaactgt
 0 AAACAAAC m6b Created no TS -0.034000 -0.120000
hsa-miR-7-1-3p tattTTTGTTatgaactgt
 0 CAACAAAU m6b Created 0.046000 0.023000 -0.400000
hsa-miR-7-2-3p tattTTTGTTatgaactgt
 0 CAACAAAU m6b Created 0.037000 0.010000 -0.700000


Mutation Mutation ID Sample Name Cancer Type
chr12:g.25206237A>C COSN5939473 RK136_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr12:g.25207287C>G COSN8706945 AOCS-095-3-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1262 agtgatTCACCCAccttgg
 0 AUGGGUGA m7b Disrupted 0.038000 0.047000 2.820000
hsa-miR-4701-3p agtgatTCACCCAccttgg
 0 AUGGGUGA m7b Disrupted 0.085000 0.094000 0.010000
hsa-miR-5187-3p agtGATTCAGccaccttgg
 0 ACUGAAUC m7b (m6c->m7b) no TS 0.096000 -4.300000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.25207349G>T COSN4898664 CPCG_0183_Pr_P_P3 [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4279 tatttttAGGAGAGacggg
 0 CUCUCCUC m7a Disrupted 0.029000 0.029000 0.010000
hsa-miR-4684-5p tatttttaGTAGAGAcggg
 9
 CUCUCUAC m7b Created -0.109000 -0.075000 -0.010000
hsa-miR-4279 tatttttAGGAGAGacggg
 0 CUCUCCUC m7a Disrupted 0.029 0.029 0.01
hsa-miR-4684-5p tatttttaGTAGAGAcggg
 0 CUCUCUAC m7b Created -0.109 -0.075 -0.01

Mutation Mutation ID Sample Name Cancer Type
chr12:g.25207929T>C COSN1568128 RK100_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4678 ttttAATACCTgtaattcc
 2
 AAGGUAUU m7b Created -0.236000 -0.228000 No effect
hsa-miR-552 ttttaatACCTGTaattcc
 0 AACAGGUG m6b Created no TS 0.003000 -0.280000
hsa-miR-4678 ttttAATACCTgtaattcc
 2
 AAGGUAUU m7b Created -0.236000 -0.228000 No effect
hsa-miR-552 ttttaatACCTGTaattcc
 0 AACAGGUG m6b Created no TS 0.003000 -0.280000
hsa-miR-4678 ttttAATACCTgtaattcc
 0 AAGGUAUU m7b Created -0.236 -0.228 No effect
hsa-miR-552 ttttaatACCTGTaattcc
 0 AACAGGUG m6b Created no TS 0.003 -0.28

Mutation Mutation ID Sample Name Cancer Type
chr12:g.25208567A>T COSN5320314 RK101_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1277-5p ttacttttATATATTaact
 0 AAAUAUAU m7b Created no TS 0.151000 -0.720000
hsa-miR-5011-5p ttactttTATATATtaact
 0 UAUAUAUA m7b Created 0.137000 0.188000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.25209150C>G COSN7324415 8058330 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3124-3p caatGGAAAGTattataag
 0 ACUUUCCU m7a Created NA NA -1.100000
hsa-miR-369-3p caatggaaaGTATTATaag
 2
 AAUAAUAC m7b (m6b->m7b) 0.200000 0.075000 -0.070000
hsa-miR-374c-5p caatggaaaGTATTATaag
 0 AUAAUACA m7a (m6a->m7a) NA NA -0.310000
hsa-miR-633 caatggaaACTATTAtaag
 2
 CUAAUAGU m7b Disrupted -0.081000 no TS 0.630000
hsa-miR-655 caatggaaaGTATTATaag
 0 AUAAUACA m7a (m6a->m7a) NA NA -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.25209206A>G COSN8585886 J38_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3143 ccccaaAATGTTATatttt
 10
 AUAACAUU m8a Created 0.236000 0.177000 -0.010000
hsa-miR-369-3p ccccaaaaTATTATatttt
 2
 AAUAAUAC m6b Disrupted 0.200000 0.167000 0.350000
hsa-miR-374a-5p ccccaaaaTATTATAtttt
 2
 UUAUAAUA m7b Disrupted 0.136000 0.182000 0.570000
hsa-miR-374b-5p ccccaaaaTATTATATttt
 2
 AUAUAAUA m8a Disrupted 0.115000 0.161000 0.050000
hsa-miR-410 ccccaaaatGTTATATTtt
 0 AAUAUAAC m8a (m7a->m8a) no TS -0.099000 -0.060000
hsa-miR-543 ccccaaAATGTTatatttt
 14
 AAACAUUC m6b Created 0.125000 0.155000 -0.010000
hsa-miR-5692b ccccaaaATATTATatttt
 2
 AAUAAUAU m7b Disrupted 0.177000 0.202000 0.580000
hsa-miR-5692c ccccaaaATATTATatttt
 2
 AAUAAUAU m7b Disrupted 0.173000 0.198000 0.470000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.25209276A>G COSN5833335 SS6003311 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-130a-5p gatgAATGTGAAgttacac
 11
 UUCACAUU m8a Created 0.115000 0.041000 No effect
hsa-miR-23a-3p gatgAATGTGAagttacac
 11
 AUCACAUU m7b Created 0.105000 -0.053000 -0.100000
hsa-miR-23b-3p gatgAATGTGAagttacac
 11
 AUCACAUU m7b Created 0.105000 -0.053000 -0.080000
hsa-miR-23c gatgAATGTGAagttacac
 11
 AUCACAUU m7b Created 0.105000 0.010000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.25209609G>A COSN8706946 AOCS-083-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1271-5p taaGTGCCAAtattcccag
 16
 CUUGGCAC m7b (m6c->m7b) -0.325000 -0.590000 No effect
hsa-miR-193a-3p taagtGCCAGTattcccag
 16
 AACUGGCC m6b Disrupted -0.410000 -0.223000 No effect
hsa-miR-193b-3p taagtGCCAGTattcccag
 16
 AACUGGCC m6b Disrupted -0.410000 -0.223000 No effect
hsa-miR-200b-3p taagtgcCAGTATTcccag
 16
 UAAUACUG m7b Disrupted -0.027000 no TS 0.010000
hsa-miR-200c-3p taagtgcCAGTATTcccag
 16
 UAAUACUG m7b Disrupted -0.027000 no TS No effect
hsa-miR-429 taagtgcCAGTATTcccag
 16
 UAAUACUG m7b Disrupted -0.027000 no TS No effect
hsa-miR-4799-3p taagTGCCAGTattcccag
 6
 ACUGGCAU m7a Disrupted 0.048000 0.048000 1.120000
hsa-miR-5588-5p taagTGCCAGTattcccag
 6
 ACUGGCAU m7a Disrupted 0.029000 0.029000 0.160000
hsa-miR-892b taagtGCCAGTattcccag
 16
 CACUGGCU m6b Disrupted -0.178000 no TS No effect
hsa-miR-96-5p taaGTGCCAAtattcccag
 16
 UUUGGCAC m7b (m6c->m7b) -0.307000 -0.563000 0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
25206021 rs184169974 C C hsa-miR-514a-3p
hsa-miR-514b-3p
8
8
 attTGTCAAAaag
attTGTCAAAaag
 Disrupted
Disrupted
N
N
 -0.051
-0.051
T hsa-miR-302c-5p
hsa-miR-495-3p
hsa-miR-552-5p
hsa-miR-5688
hsa-miR-7-1-3p
hsa-miR-7-2-3p
8
7
9
7
6
6
 attTGTTAAAaag
aTTTGTTAaaaag
atttGTTAAAAag
aTTTGTTAaaaag
ATTTGTTAaaaag
ATTTGTTAaaaag
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 0.032
0.06
0.032
0.063
0.036
0.036
25207290 rs61764370 T T hsa-miR-1262
hsa-miR-15b-3p
hsa-miR-34b-3p
hsa-miR-4701-3p
hsa-miR-6736-5p
0 agtgatTCACCCA
agTGATTCAccca
AGTGATTcaccca
agtgatTCACCCA
agtgatTCACCCA
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.009
0.105
0.122
-0.009
-0.009
G hsa-miR-4711-5p
hsa-miR-6741-5p
hsa-miR-7112-3p
2
0
2
 agTGATGCAccca
agtgatGCACCCA
aGTGATGCAccca
 Created
Created
Created
N
N
N
 0.05
-0.061
0.009
25208208 rs7973450 T T hsa-miR-302c-5p
hsa-miR-3143
hsa-miR-8060
4
5
6
 tcttcATGTTAAA
tcttcATGTTAAa
tCTTCATGttaaa
 Disrupted
Disrupted
Disrupted
N
N
N
 0.237
0.103
-0.042

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