SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001030050
Gene Symbol:	KLK3
Description:	Homo sapiens kallikrein-related peptidase 3 (KLK3), transcript variant 3, mRNA.
Gene Location:	chr19(+):51358170-51359963
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Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr19:g.50856471A>G			COSN8606180		1953_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1247-3p	attttcCCCGGGataacct	0	CCCCGGGA	m6b	Created	no TS	-0.260000	-6.400000
hsa-miR-1343	attttcCCCAGGAtaacct	1	CUCCUGGG	m7b	Disrupted	-0.218000	no TS	0.210000
hsa-miR-2110	attTTCCCCAggataacct	0	UUGGGGAA	m7b	(m7b->m6b)	-0.213000	no TS	0.510000
hsa-miR-4532	attttCCCCGGGataacct	0	CCCCGGGG	m7b	Created	no TS	-0.651000	-6.600000
hsa-miR-4667-5p	atttTCCCCAGgataacct	0	ACUGGGGA	m7b	Disrupted	-0.244000	no TS	0.440000
hsa-miR-4700-5p	atttTCCCCAGgataacct	0	UCUGGGGA	m7b	Disrupted	-0.263000	no TS	0.440000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
50856466	rs3180907	C	T	hsa-miR-2110 hsa-miR-4271 hsa-miR-4667-5p hsa-miR-4668-5p hsa-miR-4700-5p hsa-miR-4725-3p hsa-miR-6780b-5p hsa-miR-8089	0	gcattTTCCCCAg gcattTTCCCCAg gcatttTCCCCAG gcaTTTTCCCcag gcatttTCCCCAG gcattTTCCCCAg gcattTTCCCCAg gcatttTCCCCAG	Created Created Created Created Created Created Created Created	N N N N N N N N	-0.213 -0.122 -0.244 -0.081 -0.263 -0.132 -0.128 -0.235
			C	hsa-miR-1275 hsa-miR-4525 hsa-miR-4665-5p hsa-miR-4723-5p hsa-miR-5010-5p hsa-miR-5093 hsa-miR-5698 hsa-miR-625-5p hsa-miR-637 hsa-miR-6870-5p hsa-miR-7111-5p	0	gcattTCCCCCAg gcattTCCCCCAg gcattTCCCCCAg gcattTCCCCCAg gcattTCCCCCAg gCATTTCCcccag gcattTCCCCCAg gcatTTCCCCCAg gcatttCCCCCAG gcattTCCCCCAg gcattTCCCCCAg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N	-0.267 -0.203 -0.258 -0.185 -0.203 -0.035 -0.182 -0.396 -0.284 -0.182 -0.188

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