SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_005551
Gene Symbol: KLK2
Description: Homo sapiens kallikrein-related peptidase 2 (KLK2), transcript variant 2, mRNA.
Gene Location: chr19(+):51376688-51383823
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr19:g.50878635G>T 9_64387 CRC-6-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-338-3p tttctggATGCTGGAcacc
 5
 UCCAGCAU m8a Disrupted -0.288 no TS 3.79
hsa-miR-4530 tttctggaTGCTGGacacc
 7
 CCCAGCAG m6b Disrupted -0.11 no TS 1.76

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50879005G>C COSN1770613 RK025_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1915-5p acacaGCAAGGatgacgct
 2
 ACCUUGCC m6b Disrupted -0.295000 -0.185000 0.570000
hsa-miR-362-5p acacagCAAGGATgacgct
 5
 AAUCCUUG m7b Disrupted -0.098000 -0.038000 0.260000
hsa-miR-4793-5p acacagcaAGGATGacgct
 3
 ACAUCCUG m6b Disrupted -0.256000 -0.229000 0.130000
hsa-miR-500b acacagCAAGGATgacgct
 5
 AAUCCUUG m7b Disrupted -0.079000 -0.029000 0.030000
hsa-miR-502-5p acacaGCAAGGATgacgct
 2
 AUCCUUGC m8a Disrupted -0.495000 -0.348000 0.040000
hsa-miR-1915-5p acacaGCAAGGatgacgct
 2
 ACCUUGCC m6b Disrupted -0.295000 -0.185000 0.570000
hsa-miR-362-5p acacagCAAGGATgacgct
 5
 AAUCCUUG m7b Disrupted -0.098000 -0.038000 0.260000
hsa-miR-4793-5p acacagcaAGGATGacgct
 3
 ACAUCCUG m6b Disrupted -0.256000 -0.229000 0.130000
hsa-miR-500b acacagCAAGGATgacgct
 5
 AAUCCUUG m7b Disrupted -0.079000 -0.029000 0.030000
hsa-miR-502-5p acacaGCAAGGATgacgct
 2
 AUCCUUGC m8a Disrupted -0.495000 -0.348000 0.040000
hsa-miR-1915-5p acacaGCAAGGatgacgct
 2
 ACCUUGCC m6b Disrupted -0.295 -0.185 0.57
hsa-miR-362-5p acacagCAAGGATgacgct
 5
 AAUCCUUG m7b Disrupted -0.098 -0.038 0.26
hsa-miR-4793-5p acacagcaAGGATGacgct
 0 ACAUCCUG m6b Disrupted -0.256 -0.229 0.13
hsa-miR-500b acacagCAAGGATgacgct
 5
 AAUCCUUG m7b Disrupted -0.079 -0.029 0.03
hsa-miR-502-5p acacaGCAAGGATgacgct
 2
 AUCCUUGC m8a Disrupted -0.495 -0.348 0.04

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50879312A>T COSN8261651 PCSI_0083_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-515-5p gtgTGGAGAAaacagagga
 2
 UUCUCCAA m7a (m7a->m6a) -0.069000 no TS 0.030000
hsa-miR-519e-5p gtgTGGAGAAaacagagga
 2
 UUCUCCAA m7a (m7a->m6a) -0.062000 no TS No effect
hsa-miR-629-3p gtgtGGAGAAaacagagga
 2
 GUUCUCCC m6b Disrupted -0.215000 -0.178000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50879694T>C COSN5438953 RK038_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1231 tcaaaCAGACACagcatgg
 0 GUGUCUGG m7a Created NA NA -1.170000
hsa-miR-4711-3p tcaaacAGACACagcatgg
 2
 CGUGUCUU m6b Created -0.084000 -0.117000 -0.460000
hsa-miR-4718 tcaaacagaTACAGCatgg
 2
 AGCUGUAC m6b Disrupted -0.051000 no TS 4.260000
hsa-miR-4999-5p tcaaacagATACAGCAtgg
 2
 UGCUGUAU m8a Disrupted -0.102000 no TS 9.740000
hsa-miR-632 tcaaaCAGACACagcatgg
 2
 GUGUCUGC m7a Created -0.155000 -0.155000 -0.050000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50879942G>A COSN7448220 8034291 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1236 agggaaaGGAAGAGGatga
 2
 CCUCUUCC m8a Created -0.075000 -0.186000 0.010000
hsa-miR-204-5p agggAAAGGGAgaggatga
 2
 UUCCCUUU m7b Disrupted -0.030000 no TS 1.710000
hsa-miR-211-5p agggAAAGGGAgaggatga
 2
 UUCCCUUU m7b Disrupted -0.030000 no TS 2.360000
hsa-miR-3183 agggaaaggGAGAGGatga
 2
 GCCUCUCU m6b Disrupted -0.064000 no TS 1.260000
hsa-miR-4287 agggaAAGGGAGAggatga
 2
 UCUCCCUU m8a Disrupted -0.166000 no TS 0.080000
hsa-miR-4469 agggaaAGGGAGaggatga
 2
 GCUCCCUC m6b Disrupted -0.215000 -0.158000 0.130000
hsa-miR-4685-3p agggaAAGGGAGAggatga
 2
 UCUCCCUU m8a Disrupted -0.198000 no TS 0.180000
hsa-miR-4723-3p agggaaaggGAGAGGatga
 2
 CCCUCUCU m6b Disrupted -0.078000 no TS 12.200000
hsa-miR-877-3p agggaaagGAAGAGGAtga
 0 UCCUCUUC m8a Created no TS -0.192000 -1.440000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50880114G>A COSN1770614 RK046_C02 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1229 attGGTGAGAGagggatta
 0 CUCUCACC m8a Created no TS -0.158000 No effect
hsa-miR-1470 attggtgagGGAGGGatta
 2
 GCCCUCCG m6b Disrupted -0.310000 -0.143000 No effect
hsa-miR-3183 attggtgAGAGAGGgatta
 2
 GCCUCUCU m7b Created -0.064000 -0.158000 No effect
hsa-miR-4469 attggtGAGGGAGggatta
 2
 GCUCCCUC m7b Disrupted -0.215000 -0.057000 No effect
hsa-miR-4723-3p attggtgAGAGAGGGatta
 2
 CCCUCUCU m8a Created -0.078000 -0.190000 No effect
hsa-miR-642a-5p attggtgagAGAGGGAtta
 2
 GUCCCUCU m7b (m6c->m7b) -0.086000 -0.244000 No effect
hsa-miR-1229 attGGTGAGAGagggatta
 0 CUCUCACC m8a Created no TS -0.158 No effect
hsa-miR-1470 attggtgagGGAGGGatta
 0 GCCCUCCG m6b Disrupted -0.31 -0.143 No effect
hsa-miR-3183 attggtgAGAGAGGgatta
 0 GCCUCUCU m7b Created -0.064 -0.158 No effect
hsa-miR-4469 attggtGAGGGAGggatta
 2
 GCUCCCUC m7b Disrupted -0.215 -0.057 No effect
hsa-miR-4723-3p attggtgAGAGAGGGatta
 0 CCCUCUCU m8a Created -0.078 -0.19 No effect
hsa-miR-642a-5p attggtgagAGAGGGAtta
 0 GUCCCUCU m7b (m6c->m7b) -0.086 -0.244 No effect

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50880159C>G COSN7448221 8031146 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1231 aacaccCCAGACAtagcac
 0 GUGUCUGG m7b Created no TS -0.123000 -5.030000
hsa-miR-147a aacaccCCACACAtagcac
 3
 GUGUGUGG m7b Disrupted -0.190000 -0.068000 No effect
hsa-miR-3151 aacaCCCCACacatagcac
 2
 GGUGGGGC m6b Disrupted -0.146000 no TS 7.710000
hsa-miR-3170 aacACCCCAGacatagcac
 0 CUGGGGUU m7a (m6a->m7a) NA NA 0.010000
hsa-miR-4447 aacaCCCCACacatagcac
 2
 GGUGGGGG m6b Disrupted -0.139000 no TS 0.150000
hsa-miR-4472 aacaCCCCACacatagcac
 2
 GGUGGGGG m6b Disrupted -0.139000 no TS 3.640000
hsa-miR-4667-5p aacaCCCCAGacatagcac
 0 ACUGGGGA m6b Created no TS -0.126000 -0.010000
hsa-miR-491-5p aacaCCCCACacatagcac
 2
 AGUGGGGA m6b Disrupted -0.145000 no TS 0.070000
hsa-miR-637 aacaCCCCAGacatagcac
 0 ACUGGGGG m6b Created no TS -0.127000 -0.020000
hsa-miR-644a aacaccCCACACatagcac
 3
 AGUGUGGC m6b Disrupted -0.113000 no TS -0.030000
hsa-miR-654-3p aacacccCAGACATAgcac
 0 UAUGUCUG m8a Created no TS -0.162000 -0.060000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50880347G>A COSN15380216 0007_CRUK_PC_0007_T1_DNA [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-361-3p tttccgTGGGGGAatgtca
 2
 UCCCCCAG m7a Disrupted -0.603000 -0.422000 0.010000
hsa-miR-3679-3p tttccgtGGGGGAAtgtca
 1
 CUUCCCCC m7b Disrupted -0.259000 no TS 0.290000
hsa-miR-4691-5p tttccgTGGAGGAatgtca
 0 GUCCUCCA m7b Created no TS -0.305000 -0.010000
hsa-miR-361-3p tttccgTGGGGGAatgtca
 2
 UCCCCCAG m7a Disrupted -0.603000 -0.422000 0.010000
hsa-miR-3679-3p tttccgtGGGGGAAtgtca
 1
 CUUCCCCC m7b Disrupted -0.259000 no TS 0.290000
hsa-miR-4691-5p tttccgTGGAGGAatgtca
 0 GUCCUCCA m7b Created no TS -0.305000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50880551C>G COSN9226791 8051715 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-181a-5p aaacTGAATGTTgttttca
 0 AACAUUCA m8a Created no TS -0.115000 -0.460000
hsa-miR-181b-5p aaacTGAATGTTgttttca
 0 AACAUUCA m8a Created no TS -0.124000 No effect
hsa-miR-181c-5p aaacTGAATGTTgttttca
 0 AACAUUCA m8a Created no TS -0.115000 -0.030000
hsa-miR-181d aaacTGAATGTTgttttca
 0 AACAUUCA m8a Created no TS -0.133000 No effect
hsa-miR-4262 aaacTGAATGTtgttttca
 0 GACAUUCA m7b Created no TS -0.124000 -1.410000
hsa-miR-543 aaactGAATGTTgttttca
 0 AAACAUUC m7b Created no TS -0.133000 -0.110000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
50879007 rs4846 A A hsa-miR-1915-5p
hsa-miR-362-5p
hsa-miR-4793-5p
hsa-miR-500b-5p
hsa-miR-502-5p
hsa-miR-5196-3p
hsa-miR-6841-3p
2
5
3
5
2
3
2
 GCAAGGAtgacgc
gCAAGGATgacgc
gcaAGGATGAcgc
gCAAGGATgacgc
GCAAGGAtgacgc
gcaAGGATGAcgc
GCAAGGAtgacgc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.11
-0.06
-0.027
-0.05
-0.147
-0.028
-0.1
T hsa-miR-3200-3p
hsa-miR-4714-3p
2
3
 GCAAGGTtgacgc
gcaAGGTTGAcgc
 Created
Created
N
N
 -0.16
-0.051
50879042 rs9884 G G hsa-miR-1825
hsa-miR-361-3p
hsa-miR-371b-3p
hsa-miR-4313
2
2
1
1
 ctggggGCACTGG
CTGGGGGcactgg
ctggGGGCACTgg
ctGGGGGCActgg
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.081
-0.116
-0.128
-0.17
C hsa-miR-3677-5p
hsa-miR-5693
hsa-miR-663b
hsa-miR-874-5p
1
1
1
1
 ctggGGCCACTgg
ctgggGCCACTGg
ctgGGGCCACtgg
cTGGGGCCActgg
 Created
Created
Created
Created
N
N
N
N
 -0.101
-0.053
-0.16
-0.349
50879541 rs183546409 G G hsa-miR-154-3p
hsa-miR-485-3p
hsa-miR-487a-3p
hsa-miR-539-3p
1
1
1
1
 aaggatGTATGAT
aaggaTGTATGAt
aaggatGTATGAT
aaggaTGTATGAt
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.123
-0.055
-0.109
-0.064
A hsa-miR-362-5p
hsa-miR-500b-5p
hsa-miR-501-5p
1
1
1
 AAGGATAtatgat
AAGGATAtatgat
AAGGATAtatgat
 Created
Created
Created
N
N
N
 -0.068
-0.067
-0.002
50879626 rs143825608 C C hsa-miR-4636
1
 gtaggACGAGTAt
 Disrupted
N
 -0.118
T hsa-miR-4793-5p
hsa-miR-5196-3p
hsa-miR-6870-3p
1
1
1
 gtAGGATGAgtat
gtAGGATGAgtat
gtaGGATGAGtat
 Created
Created
Created
N
N
N
 -0.008
-0.017
-0.124
50879693 rs148175263 A A hsa-miR-4999-5p
2
 aaacagATACAGC
 Disrupted
N
 -0.06
G hsa-miR-4718
2
 aaacagGTACAGC
 Created
N
 -0.134
50879698 rs73592873 G G hsa-miR-1537-5p
hsa-miR-4718
hsa-miR-4999-5p
2
2
2
 gaTACAGCAtggt
gaTACAGCAtggt
gATACAGCAtggt
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.038
-0.051
-0.102
A hsa-miR-3613-5p
hsa-miR-4716-5p
2
1
 gaTACAACAtggt
gatacAACATGGt
 Created
Created
N
N
 -0.011
-0.008
50879944 rs80050017 G G hsa-miR-3183
hsa-miR-4287
hsa-miR-4469
hsa-miR-4685-3p
hsa-miR-4723-3p
hsa-miR-5196-3p
hsa-miR-6769b-3p
hsa-miR-6867-3p
hsa-miR-7111-3p
hsa-miR-7113-3p
2
2
2
2
2
1
2
2
2
2
 aaggGAGAGGAtg
AAGGGAGAggatg
aAGGGAGAggatg
AAGGGAGAggatg
aaggGAGAGGAtg
aagggaGAGGATG
aaggGAGAGGAtg
aAGGGAGAggatg
aaggGAGAGGAtg
aAGGGAGAggatg
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
N
 -0.064
-0.166
-0.057
-0.198
-0.078
-0.187
-0.067
-0.11
-0.095
-0.068
T hsa-miR-188-5p
hsa-miR-3927-5p
hsa-miR-6866-3p
2
2
2
 AAGGGATAggatg
aaggGATAGGAtg
AAGGGATAggatg
 Created
Created
Created
N
N
N
 -0.135
-0.069
-0.177
50879945 rs75200917 A A hsa-miR-3183
hsa-miR-4287
hsa-miR-4469
hsa-miR-4685-3p
hsa-miR-4723-3p
hsa-miR-4793-5p
hsa-miR-5196-3p
hsa-miR-6769b-3p
hsa-miR-6867-3p
hsa-miR-7111-3p
hsa-miR-7113-3p
2
2
2
2
2
1
1
2
2
2
2
 aggGAGAGGAtga
AGGGAGAggatga
AGGGAGAggatga
AGGGAGAggatga
aggGAGAGGAtga
agggagAGGATGA
agggaGAGGATGA
aggGAGAGGAtga
AGGGAGAggatga
aggGAGAGGAtga
AGGGAGAggatga
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
N
N
 -0.064
-0.09
-0.057
-0.094
-0.078
-0.022
-0.231
-0.067
-0.11
-0.095
-0.068
T hsa-miR-6777-3p
2
 aggGAGTGGAtga
 Created
N
 -0.09

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