SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001002231
Gene Symbol: KLK2
Description: Homo sapiens kallikrein-related peptidase 2 (KLK2), transcript variant 2, mRNA.
Gene Location: chr19(+):51376688-51383823
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr19:g.50878635G>T 9_64387 CRC-6-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-338-3p tttctggATGCTGGAcacc
 5
 UCCAGCAU m8a Disrupted -0.249 no TS 3.68
hsa-miR-4530 tttctggaTGCTGGacacc
 7
 CCCAGCAG m6b Disrupted -0.093 no TS 0.14

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50879005G>C COSN1770613 RK025_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1915-5p acacaGCAAGGatgacgct
 2
 ACCUUGCC m6b Disrupted -0.272000 -0.179000 0.570000
hsa-miR-362-5p acacagCAAGGATgacgct
 5
 AAUCCUUG m7b Disrupted -0.069000 -0.030000 0.260000
hsa-miR-4793-5p acacagcaAGGATGacgct
 3
 ACAUCCUG m6b Disrupted -0.240000 -0.229000 0.130000
hsa-miR-500b acacagCAAGGATgacgct
 5
 AAUCCUUG m7b Disrupted -0.050000 -0.021000 0.030000
hsa-miR-502-5p acacaGCAAGGATgacgct
 2
 AUCCUUGC m8a Disrupted -0.466000 -0.340000 0.040000
hsa-miR-1915-5p acacaGCAAGGatgacgct
 2
 ACCUUGCC m6b Disrupted -0.272000 -0.179000 0.570000
hsa-miR-362-5p acacagCAAGGATgacgct
 5
 AAUCCUUG m7b Disrupted -0.069000 -0.030000 0.260000
hsa-miR-4793-5p acacagcaAGGATGacgct
 3
 ACAUCCUG m6b Disrupted -0.240000 -0.229000 0.130000
hsa-miR-500b acacagCAAGGATgacgct
 5
 AAUCCUUG m7b Disrupted -0.050000 -0.021000 0.030000
hsa-miR-502-5p acacaGCAAGGATgacgct
 2
 AUCCUUGC m8a Disrupted -0.466000 -0.340000 0.040000
hsa-miR-1915-5p acacaGCAAGGatgacgct
 2
 ACCUUGCC m6b Disrupted -0.272 -0.179 0.57
hsa-miR-362-5p acacagCAAGGATgacgct
 5
 AAUCCUUG m7b Disrupted -0.069 -0.03 0.26
hsa-miR-4793-5p acacagcaAGGATGacgct
 0 ACAUCCUG m6b Disrupted -0.24 -0.229 0.13
hsa-miR-500b acacagCAAGGATgacgct
 5
 AAUCCUUG m7b Disrupted -0.05 -0.021 0.03
hsa-miR-502-5p acacaGCAAGGATgacgct
 2
 AUCCUUGC m8a Disrupted -0.466 -0.34 0.04

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50879312A>T COSN8261651 PCSI_0083_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-515-5p gtgTGGAGAAaacagagga
 2
 UUCUCCAA m7a (m7a->m6a) -0.053000 no TS 0.030000
hsa-miR-519e-5p gtgTGGAGAAaacagagga
 2
 UUCUCCAA m7a (m7a->m6a) -0.046000 no TS No effect
hsa-miR-629-3p gtgtGGAGAAaacagagga
 2
 GUUCUCCC m6b Disrupted -0.161000 -0.140000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50879694T>C COSN5438953 RK038_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1231 tcaaaCAGACACagcatgg
 0 GUGUCUGG m7a Created NA NA -1.170000
hsa-miR-4711-3p tcaaacAGACACagcatgg
 2
 CGUGUCUU m6b Created -0.067000 -0.100000 -0.460000
hsa-miR-4718 tcaaacagaTACAGCatgg
 2
 AGCUGUAC m6b Disrupted -0.051000 no TS 4.260000
hsa-miR-4999-5p tcaaacagATACAGCAtgg
 2
 UGCUGUAU m8a Disrupted -0.102000 no TS 9.740000
hsa-miR-632 tcaaaCAGACACagcatgg
 2
 GUGUCUGC m7a Created -0.133000 -0.133000 -0.050000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50879942G>A COSN7448220 8034291 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1236 agggaaaGGAAGAGGatga
 2
 CCUCUUCC m8a Created -0.054000 -0.165000 0.010000
hsa-miR-204-5p agggAAAGGGAgaggatga
 2
 UUCCCUUU m7b Disrupted -0.030000 no TS 1.710000
hsa-miR-211-5p agggAAAGGGAgaggatga
 2
 UUCCCUUU m7b Disrupted -0.030000 no TS 2.360000
hsa-miR-3183 agggaaaggGAGAGGatga
 2
 GCCUCUCU m6b Disrupted -0.064000 no TS 1.260000
hsa-miR-4287 agggaAAGGGAGAggatga
 2
 UCUCCCUU m8a Disrupted -0.166000 no TS 0.060000
hsa-miR-4469 agggaaAGGGAGaggatga
 2
 GCUCCCUC m6b Disrupted -0.215000 -0.158000 0.130000
hsa-miR-4685-3p agggaAAGGGAGAggatga
 2
 UCUCCCUU m8a Disrupted -0.198000 no TS 0.180000
hsa-miR-4723-3p agggaaaggGAGAGGatga
 2
 CCCUCUCU m6b Disrupted -0.078000 no TS 12.200000
hsa-miR-877-3p agggaaagGAAGAGGAtga
 0 UCCUCUUC m8a Created no TS -0.192000 -1.440000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50880114G>A COSN1770614 RK046_C02 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1229 attGGTGAGAGagggatta
 0 CUCUCACC m8a Created no TS -0.158000 No effect
hsa-miR-1470 attggtgagGGAGGGatta
 2
 GCCCUCCG m6b Disrupted -0.294000 -0.127000 No effect
hsa-miR-3183 attggtgAGAGAGGgatta
 2
 GCCUCUCU m7b Created -0.064000 -0.158000 No effect
hsa-miR-4469 attggtGAGGGAGggatta
 2
 GCUCCCUC m7b Disrupted -0.215000 -0.057000 No effect
hsa-miR-4723-3p attggtgAGAGAGGGatta
 2
 CCCUCUCU m8a Created -0.078000 -0.190000 No effect
hsa-miR-642a-5p attggtgagAGAGGGAtta
 2
 GUCCCUCU m7b (m6c->m7b) -0.086000 -0.244000 No effect
hsa-miR-1229 attGGTGAGAGagggatta
 0 CUCUCACC m8a Created no TS -0.158 No effect
hsa-miR-1470 attggtgagGGAGGGatta
 0 GCCCUCCG m6b Disrupted -0.294 -0.127 No effect
hsa-miR-3183 attggtgAGAGAGGgatta
 0 GCCUCUCU m7b Created -0.064 -0.158 No effect
hsa-miR-4469 attggtGAGGGAGggatta
 2
 GCUCCCUC m7b Disrupted -0.215 -0.057 No effect
hsa-miR-4723-3p attggtgAGAGAGGGatta
 0 CCCUCUCU m8a Created -0.078 -0.19 No effect
hsa-miR-642a-5p attggtgagAGAGGGAtta
 0 GUCCCUCU m7b (m6c->m7b) -0.086 -0.244 No effect

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50880159C>G COSN7448221 8031146 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1231 aacaccCCAGACAtagcac
 0 GUGUCUGG m7b Created no TS -0.123000 -5.030000
hsa-miR-147a aacaccCCACACAtagcac
 3
 GUGUGUGG m7b Disrupted -0.174000 -0.052000 No effect
hsa-miR-3151 aacaCCCCACacatagcac
 2
 GGUGGGGC m6b Disrupted -0.146000 no TS No effect
hsa-miR-3170 aacACCCCAGacatagcac
 0 CUGGGGUU m7a (m6a->m7a) NA NA 0.010000
hsa-miR-4447 aacaCCCCACacatagcac
 2
 GGUGGGGG m6b Disrupted -0.139000 no TS 0.120000
hsa-miR-4472 aacaCCCCACacatagcac
 2
 GGUGGGGG m6b Disrupted -0.139000 no TS 4.450000
hsa-miR-4667-5p aacaCCCCAGacatagcac
 0 ACUGGGGA m6b Created no TS -0.126000 -0.010000
hsa-miR-491-5p aacaCCCCACacatagcac
 2
 AGUGGGGA m6b Disrupted -0.145000 no TS 0.070000
hsa-miR-637 aacaCCCCAGacatagcac
 0 ACUGGGGG m6b Created no TS -0.127000 -0.020000
hsa-miR-644a aacaccCCACACatagcac
 3
 AGUGUGGC m6b Disrupted -0.113000 no TS -0.030000
hsa-miR-654-3p aacacccCAGACATAgcac
 0 UAUGUCUG m8a Created no TS -0.162000 -0.060000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50880347G>A COSN15380216 0007_CRUK_PC_0007_T1_DNA [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-361-3p tttccgTGGGGGAatgtca
 2
 UCCCCCAG m7a Disrupted -0.849000 -0.576000 0.010000
hsa-miR-3679-3p tttccgtGGGGGAAtgtca
 1
 CUUCCCCC m7b Disrupted -0.259000 no TS 0.290000
hsa-miR-4691-5p tttccgTGGAGGAatgtca
 0 GUCCUCCA m7b Created no TS -0.305000 -0.010000
hsa-miR-361-3p tttccgTGGGGGAatgtca
 2
 UCCCCCAG m7a Disrupted -0.849000 -0.576000 0.010000
hsa-miR-3679-3p tttccgtGGGGGAAtgtca
 1
 CUUCCCCC m7b Disrupted -0.259000 no TS 0.290000
hsa-miR-4691-5p tttccgTGGAGGAatgtca
 0 GUCCUCCA m7b Created no TS -0.305000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.50880551C>G COSN9226791 8051715 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-181a-5p aaacTGAATGTTgttttca
 0 AACAUUCA m8a Created no TS -0.115000 -0.460000
hsa-miR-181b-5p aaacTGAATGTTgttttca
 0 AACAUUCA m8a Created no TS -0.124000 No effect
hsa-miR-181c-5p aaacTGAATGTTgttttca
 0 AACAUUCA m8a Created no TS -0.115000 -0.030000
hsa-miR-181d aaacTGAATGTTgttttca
 0 AACAUUCA m8a Created no TS -0.133000 No effect
hsa-miR-4262 aaacTGAATGTtgttttca
 0 GACAUUCA m7b Created no TS -0.124000 -0.070000
hsa-miR-543 aaactGAATGTTgttttca
 0 AAACAUUC m7b Created no TS -0.133000 -0.110000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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