SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_004235
Gene Symbol:	KLF4
Description:	Homo sapiens Kruppel-like factor 4 (gut) (KLF4), mRNA.
Gene Location:	chr9(-):110247132-110252047
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.107484981T>C			COSN9275064		C0057T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-556-3p	tatGTAATATaaatttaag	2	AUAUUACC	m7a	(m7a->m6b)	-0.146000	-0.146000	0.110000
hsa-miR-656	tatgTAATATaaatttaag	1	AAUAUUAU	m6b	Disrupted	-0.070000	-0.042000	0.130000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.107484986T>C			COSN9275065		C0021T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-25-3p	ataaataTGCAATataaat	17	CAUUGCAC	m6b	Created	-0.422000	-0.561000	-0.230000
hsa-miR-363-3p	ataaataTGCAATataaat	17	AAUUGCAC	m6b	Created	-0.429000	-0.571000	-0.510000
hsa-miR-367-3p	ataaataTGCAATataaat	17	AAUUGCAC	m6b	Created	-0.428000	-0.570000	-0.370000
hsa-miR-448	ataaATATGCAAtataaat	0	UUGCAUAU	m8a	Created	no TS	-0.361000	-0.020000
hsa-miR-556-3p	ataaatatGTAATATaaat	2	AUAUUACC	m7a	Disrupted	-0.146000	-0.146000	0.140000
hsa-miR-5580-3p	ataaATATGTaatataaat	19	CACAUAUG	m6b	Disrupted	-0.078000	no TS	6.400000
hsa-miR-656	ataaatatgTAATATaaat	1	AAUAUUAU	m6b	Disrupted	-0.070000	-0.042000	0.140000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.107485011A>G			COSN9694339		AOCS-081-1-1		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-376c	ttttTCTATGTagttcctt	0	AACAUAGA	m7b	Created	no TS	-0.333000	-7.850000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.107485042T>C			COSN2304568		RK080_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-124-3p	tcccaagtaTGCCTTAagc	14	UAAGGCAC	m7a	(m7a->m6a)	-0.293000	-0.153000	8.890000
hsa-miR-3714	tcccaagtaTGCCTTaagc	14	GAAGGCAG	m6b	Disrupted	-0.252000	-0.139000	0.890000
hsa-miR-3910	tcccaagtATGCCTTaagc	14	AAAGGCAU	m7b	Disrupted	-0.482000	-0.155000	4.070000
hsa-miR-506-3p	tcccaagtaTGCCTTAagc	14	UAAGGCAC	m7a	(m7a->m6a)	-0.283000	-0.153000	3.860000
hsa-miR-524-3p	tcccaagtaCGCCTTaagc	0	GAAGGCGC	m6b	Created	no TS	-0.247000	-7.760000
hsa-miR-525-3p	tcccaagtaCGCCTTaagc	0	GAAGGCGC	m6b	Created	no TS	-0.247000	-3.730000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.107485152A>T			COSN9275066		C0031T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3974	ttaTGACCTTagtcaggta	0	AAAGGUCA	m7b	(m6c->m7b)	no TS	-0.341000	-2.690000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
107485071	rs11550076	T	T	hsa-miR-137 hsa-miR-25-3p hsa-miR-32-5p hsa-miR-363-3p hsa-miR-367-3p hsa-miR-92a-3p hsa-miR-92b-3p hsa-miR-944	20 20 20 20 20 20 20 20	gtGCAATAAtttg GTGCAATAatttg GTGCAATAatttg GTGCAATAatttg GTGCAATAatttg GTGCAATAatttg GTGCAATAatttg gtgcAATAATTtg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	LT LT N N N N N N	-0.082 -0.35 -0.339 -0.35 -0.339 -0.329 -0.329 0.012
			C	hsa-miR-4684-3p hsa-miR-744-3p	20 20	gTGCAACAatttg gtGCAACAAtttg	Created Created	N N	-0.155 -0.13
107485383	rs11788360	A	A	hsa-miR-25-3p hsa-miR-32-5p hsa-miR-363-3p hsa-miR-367-3p hsa-miR-92a-3p hsa-miR-92b-3p	17 17 17 17 17 17	TGCAATAtaagca TGCAATAtaagca TGCAATAtaagca TGCAATAtaagca TGCAATAtaagca TGCAATAtaagca	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	LT N N N N N	-0.072 -0.079 -0.079 -0.089 -0.069 -0.072

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