SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_016531
Gene Symbol:	KLF3
Description:	Homo sapiens Kruppel-like factor 3 (basic) (KLF3), mRNA.
Gene Location:	chr4(+):38665789-38703129
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.38697827T>C			COSN6830154		RK187_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-105-3p	gacttCATCCGaatcgagt	0	ACGGAUGU	m6b	Created	no TS	-0.188000	-0.020000
hsa-miR-1245b-3p	gactTCATCTGAatcgagt	3	UCAGAUGA	m8a	Disrupted	-0.221000	no TS	1.400000
hsa-miR-1255b-5p	gactTCATCCGaatcgagt	2	CGGAUGAG	m7a	Created	-0.109000	-0.109000	-2.830000
hsa-miR-3942-3p	gacttcATCTGAAtcgagt	3	UUUCAGAU	m7b	Disrupted	-0.074000	-0.058000	0.110000

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.38697962G>A			COSN7489901		8016470		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4716-5p	gttttcatAACATGGAgtc	0	UCCAUGUU	m8a	Created	no TS	-0.076000	-0.340000
hsa-miR-5581-3p	gttttcataGCATGGAgtc	6	UUCCAUGC	m7b	(m7b->m6c)	-0.144000	-0.021000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.38698187A>G			COSN6830155		RK128_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1285-5p	taataTGAGATCatcaaac	0	GAUCUCAC	m7a	Disrupted	NA	NA	No effect
hsa-miR-3682-3p	taatatgagATCATCAaac	3	UGAUGAUA	m7a	(m7a->m6b)	-0.250000	-0.214000	4.090000
hsa-miR-4695-3p	taataTGAGATCAtcaaac	2	UGAUCUCA	m8a	Disrupted	-0.184000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.38698654C>A			COSN9039867		AOCS-137-3-7		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4273	gtgtcAGAACAaactgaaa	2	GUGUUCUC	m6b	Disrupted	-0.104000	-0.151000	0.080000
hsa-miR-4328	gtgtcagaaAAAACTGaaa	2	CCAGUUUU	m7b	(m6c->m7b)	-0.026000	-0.006000	No effect
hsa-miR-4677-5p	gtgtcAGAACAAactgaaa	2	UUGUUCUU	m7a	Disrupted	-0.264000	-0.315000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.38698837A>G			COSN2027813		RK194_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-409-5p	tgggtgcatGTAACCaaat	2	AGGUUACC	m6b	Created	-0.109000	-0.112000	No effect
hsa-miR-4666a-5p	tgggtgCATGTAaccaaat	12	AUACAUGU	m6b	Created	-0.508000	-0.414000	-0.090000

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.38698854C>T			COSN7638506		ASHPC_0011_Pa_P		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3161	attcccctTTATCAagaat	2	CUGAUAAG	m6b	Created	-0.004000	0.119000	No effect
hsa-miR-3179	attCCCCTTCatcaagaat	4	AGAAGGGG	m7b	(m7b->m6b)	-0.166000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.38699072T>G			COSN5570644		RK298_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1281	ctaaGAGGCGAagaggtcc	0	UCGCCUCC	m7a	Created	no TS	-0.063000	No effect
hsa-miR-2682-3p	ctAAGAGGCGaagaggtcc	1	CGCCUCUU	m8a	(m7a->m8a)	-0.164000	-0.137000	No effect
hsa-miR-877-3p	ctaagaggcGAAGAGGtcc	0	UCCUCUUC	m7b	(m6c->m7b)	-0.079000	0.014000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.38700281T>G			COSN9039869		AOCS-058-1-5		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.38701295A>C			COSN14648095		ASHPC_0002_Pa_P_4		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-129-5p	tccaGCAAAAAtctacaaa	1	CUUUUUGC	m7b	Disrupted	-0.066000	no TS	0.460000
hsa-miR-376a-5p	tccagcaaaAATCTACaaa	10	GUAGAUUC	m7a	(m7a->m6b)	-0.031000	-0.031000	No effect
hsa-miR-576-3p	tccagcaaACATCTacaaa	0	AAGAUGUG	m6b	Created	no TS	-0.091000	-0.020000
hsa-miR-129-5p	tccaGCAAAAAtctacaaa	1	CUUUUUGC	m7b	Disrupted	-0.066000	no TS	0.460000
hsa-miR-376a-5p	tccagcaaaAATCTACaaa	10	GUAGAUUC	m7a	(m7a->m6b)	-0.031000	-0.031000	No effect
hsa-miR-576-3p	tccagcaaACATCTacaaa	0	AAGAUGUG	m6b	Created	no TS	-0.091000	-0.020000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
38698009	rs77800130	C	C	hsa-miR-219b-3p hsa-miR-2682-3p hsa-miR-3152-5p hsa-miR-6781-3p hsa-miR-6836-3p	4 2 3 2 3	aagagGCAATTCc AAGAGGCAattcc aaGAGGCAAttcc AAGAGGCAattcc aaGAGGCAAttcc	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	0.03 -0.164 -0.125 -0.133 -0.084
			A	hsa-miR-1238-3p hsa-miR-670-3p hsa-miR-6780a-3p hsa-miR-6881-3p hsa-miR-7111-3p hsa-miR-877-3p	3 3 2 2 2 2	aaGAGGAAAttcc aaGAGGAAAttcc aAGAGGAAattcc AAGAGGAAattcc aAGAGGAAattcc AAGAGGAaattcc	Created Created Created Created Created Created	N N N N N N	-0.032 -0.004 -0.016 -0.076 -0.031 -0.106
38698186	rs190993457	G	G	hsa-miR-4695-3p hsa-miR-7641	2 2	ataTGAGATCAtc atatGAGATCAtc	Disrupted Disrupted	N N	-0.184 -0.152
			A	hsa-miR-5007-3p	2	ATATGAAatcatc	Created	N	0.026
38698339	rs143570144	C	C	hsa-miR-3161 hsa-miR-4475 hsa-miR-6892-5p	2 2 2	tattccCTTATCA tatTCCCTTAtca tatTCCCTTAtca	Disrupted Disrupted Disrupted	N N N	-0.044 -0.067 -0.149
			G	hsa-miR-191-5p hsa-miR-3669	2 13	taTTCCGTTAtca TATTCCGttatca	Created Created	N N	-0.258 -0.17
38699084	rs187416018	C	C	hsa-miR-1238-5p hsa-miR-1255a hsa-miR-1255b-5p hsa-miR-4481 hsa-miR-4648 hsa-miR-4745-5p hsa-miR-4758-5p	4 7 7 3 3 3 4	gtcCCACTCAtcc gtcccaCTCATCC gtcccaCTCATCC gtCCCACTCAtcc GTCCCACtcatcc gtCCCACTCAtcc gtcCCACTCAtcc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	0.061 0.061 0.061 -0.039 0.022 -0.039 0.07
			T	hsa-miR-4790-3p	4	gtcCCATTCAtcc	Created	N	0.07

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