SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_007249
Gene Symbol: KLF12
Description: Homo sapiens Kruppel-like factor 12 (KLF12), mRNA.
Gene Location: chr13(-):74260148-74708066
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr13:g.73686223T>C COSN7417181 8066067 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3908 ttggtgCATTGCTtttctg
 7
 GAGCAAUG m7b Disrupted -0.160000 0.009000 0.080000
hsa-miR-501-3p ttGGTGCATTgcttttctg
 2
 AAUGCACC m8a (m8a->m7b) -0.245000 -0.217000 -0.010000
hsa-miR-502-3p ttGGTGCATTgcttttctg
 2
 AAUGCACC m8a (m8a->m7b) -0.245000 -0.217000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr13:g.73686466A>G COSN9470417 C0092T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr13:g.73686841C>T COSN7417182 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-433 attggATCATGAgatctgt
 1
 AUCAUGAU m7b Created 0.081000 0.092000 No effect
hsa-miR-4695-3p attggatcaTGAGATCtgt
 0 UGAUCUCA m7b (m6b->m7b) -0.003000 -0.093000 -0.010000
hsa-miR-640 atTGGATCATgagatctgt
 13
 AUGAUCCA m8a (m7b->m8a) -0.098000 -0.125000 -0.070000

Mutation Mutation ID Sample Name Cancer Type
chr13:g.73687064A>C 0_439 Prostate cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1909-3p aagataccCCCCTGCcact
 31
 CGCAGGGG m7b Created no TS -0.119 -0.04
hsa-miR-3665 aagataccCACCTGCcact
 31
 AGCAGGUG m7b Disrupted -0.192 -0.123 0.03

Mutation Mutation ID Sample Name Cancer Type
chr13:g.73687981C>T COSN5344757 RK124_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-296-5p agactGGGGCCCTtctcag
 1
 AGGGCCCC m8a Disrupted -0.153000 no TS 2.390000
hsa-miR-3154 agactggggCCCTTCTcag
 1
 CAGAAGGG m7b (m7b->m6b) 0.075000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr13:g.73689253G>A COSN8420213 AOCS-133-1-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-204-5p aagaAAAGGGAgacggaaa
 2
 UUCCCUUU m7b Disrupted -0.151000 -0.184000 No effect
hsa-miR-211-5p aagaAAAGGGAgacggaaa
 2
 UUCCCUUU m7b Disrupted -0.123000 -0.156000 0.020000
hsa-miR-340-3p aagaaaaggGAGACGGAaa
 0 UCCGUCUC m8a (m8a->m7a) -0.142000 -0.052000 No effect
hsa-miR-4287 aagaaAAGGGAGAcggaaa
 2
 UCUCCCUU m8a Disrupted -0.329000 -0.306000 0.010000
hsa-miR-4469 aagaaaAGGGAGacggaaa
 2
 GCUCCCUC m6b Disrupted -0.115000 -0.121000 0.010000
hsa-miR-4685-3p aagaaAAGGGAGAcggaaa
 2
 UCUCCCUU m8a Disrupted -0.311000 -0.299000 1.960000

Mutation Mutation ID Sample Name Cancer Type
chr13:g.73689451G>T COSN1624943 RK047_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2113 catctcagaGCACAAATtc
 11
 AUUUGUGC m8a (m8a->m7a) 0.142000 0.093000 0.060000
hsa-miR-218-5p catctcagAGCACAAattc
 11
 UUGUGCUU m7a Disrupted 0.023000 0.003000 No effect
hsa-miR-301a-5p catcTCAGAGCacaaattc
 5
 GCUCUGAC m7a Disrupted -0.163000 -0.163000 0.010000
hsa-miR-3194-3p catctCAGAGCacaaattc
 10
 AGCUCUGC m6b Disrupted -0.097000 -0.124000 No effect
hsa-miR-3200-5p catCTCAGATcacaaattc
 11
 AAUCUGAG m7b (m6c->m7b) 0.093000 0.110000 -0.650000
hsa-miR-3921 catCTCAGAGcacaaattc
 8
 UCUCUGAG m7b (m7b->m6c) -0.786000 -0.816000 0.010000
hsa-miR-4653-5p catCTCAGAGcacaaattc
 8
 UCUCUGAG m7b (m7b->m6c) -0.786000 -0.797000 No effect
hsa-miR-5691 catctCAGAGCAcaaattc
 10
 UUGCUCUG m7b Disrupted -0.214000 -0.221000 No effect
hsa-miR-2113 catctcagaGCACAAATtc
 0 AUUUGUGC m8a (m8a->m7a) 0.142 0.093 0.01
hsa-miR-218-5p catctcagAGCACAAattc
 0 UUGUGCUU m7a Disrupted 0.023 0.003 No effect
hsa-miR-301a-5p catcTCAGAGCacaaattc
 0 GCUCUGAC m7a Disrupted -0.163 -0.163 0.01
hsa-miR-3194-3p catctCAGAGCacaaattc
 0 AGCUCUGC m6b Disrupted -0.097 -0.124 No effect
hsa-miR-3200-5p catCTCAGATcacaaattc
 0 AAUCUGAG m7b (m6c->m7b) 0.093 0.11 -0.11
hsa-miR-3921 catCTCAGAGcacaaattc
 0 UCUCUGAG m7b (m7b->m6c) -0.786 -0.816 0.01
hsa-miR-4653-5p catCTCAGAGcacaaattc
 0 UCUCUGAG m7b (m7b->m6c) -0.786 -0.797 No effect
hsa-miR-5691 catctCAGAGCAcaaattc
 0 UUGCUCUG m7b Disrupted -0.214 -0.221 No effect

Mutation Mutation ID Sample Name Cancer Type
chr13:g.73689771G>T COSN5726950 HX33T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-147b atatcaaaCGCACAaattc
 2
 GUGUGCGG m6b Disrupted -0.117000 no TS 0.030000
hsa-miR-210 atatcaaACGCACAaattc
 2
 CUGUGCGU m7b Disrupted -0.220000 no TS No effect
hsa-miR-2113 atatcaaacGCACAAATtc
 11
 AUUUGUGC m8a (m8a->m7a) 0.142000 0.111000 No effect
hsa-miR-5707 ataTCAAACGcacaaattc
 1
 ACGUUUGA m7b (m7b->m6c) -0.125000 -0.042000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr13:g.73690297A>G COSN1624944 RK023_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-10b-3p aagGAATCTGTactcgcaa
 0 ACAGAUUC m8a Created 0.001000 0.054000 No effect
hsa-miR-376a-5p aagGAATCTAtactcgcaa
 0 GUAGAUUC m7b (m7b->m6c) 0.067000 no TS 0.390000
hsa-miR-10b-3p aagGAATCTGTactcgcaa
 0 ACAGAUUC m8a Created 0.001 0.054 No effect
hsa-miR-376a-5p aagGAATCTAtactcgcaa
 0 GUAGAUUC m7b (m7b->m6c) 0.067 no TS 0.39

Mutation Mutation ID Sample Name Cancer Type
chr13:g.73691775G>A COSN4739414 tumor_4191799 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-382-3p cattaGAATGATaacattt
 7
 AAUCAUUC m7b Disrupted 0.026000 no TS No effect
hsa-miR-4795-3p cattagAATAATAacattt
 0 AUAUUAUU m7b Created no TS 0.269000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr13:g.73691911G>A COSN1624945 RK001_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3119 gattagAAAAGCCgttttc
 0 UGGCUUUU m7b Created no TS 0.059000 -0.010000
hsa-miR-337-5p gattagaaaAGCCGTTttc
 0 GAACGGCU m7b (m6b->m7b) no TS -0.165000 -0.010000
hsa-miR-4485 gattagaaaGGCCGTTttc
 1
 UAACGGCC m7b (m7b->m6b) -0.213000 no TS 4.450000
hsa-miR-3119 gattagAAAAGCCgttttc
 0 UGGCUUUU m7b Created no TS 0.059 -2.86
hsa-miR-337-5p gattagaaaAGCCGTTttc
 0 GAACGGCU m7b (m6b->m7b) no TS -0.165 -0.01
hsa-miR-4485 gattagaaaGGCCGTTttc
 0 UAACGGCC m7b (m7b->m6b) -0.213 no TS 4.45

Mutation Mutation ID Sample Name Cancer Type
chr13:g.73693823T>C COSN7417183 8014573 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1226-3p agggGCTGGTGAgattttt
 11
 UCACCAGC m8a Disrupted -0.025000 -0.003000 No effect
hsa-miR-1229 aggggctGGTGAGAttttt
 6
 CUCUCACC m7b Disrupted -0.089000 no TS 0.030000
hsa-miR-1285-5p aggggctgGTGAGATtttt
 11
 GAUCUCAC m7b Disrupted 0.020000 -0.013000 No effect
hsa-miR-216a aggggctggTGAGATTttt
 4
 UAAUCUCA m7b (m7b->m6b) 0.028000 -0.068000 No effect
hsa-miR-3194-5p aggGGCTGGCgagattttt
 12
 GGCCAGCC m7b (m6c->m7b) -0.157000 -0.207000 No effect
hsa-miR-4733-3p aggggCTGGTGagattttt
 11
 CCACCAGG m6b Disrupted 0.025000 0.005000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr13:g.73694496G>A COSN1161594 HX12T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4279 gcgcctcttGAGGAGAaaa
 0 CUCUCCUC m7b (m7b->m6b) -0.127000 0.012000 2.050000
hsa-miR-4279 gcgcctcttGAGGAGAaaa
 0 CUCUCCUC m7b (m7b->m6b) -0.127 0.012 2.05

Mutation Mutation ID Sample Name Cancer Type
chr13:g.73694994G>T 0_438 Lung cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-138-1-3p atgaAAGTAGaaacgaaga
 18
 GCUACUUC m6b Disrupted -0.02 no TS 0.01

Mutation Mutation ID Sample Name Cancer Type
chr13:g.73695337T>C 10_3614 6408 Breast cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3185 acaCTTCTTCTggtctgaa
 8
 AGAAGAAG m8a Created 0.154 0.067 -0.01

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
73686289 rs192111552 T T hsa-miR-146a-3p
hsa-miR-301a-5p
hsa-miR-3921
hsa-miR-4251
hsa-miR-4329
hsa-miR-4653-5p
hsa-miR-580-3p
hsa-miR-6761-5p
17
17
17
16
16
17
17
16
 ctattcTCAGAGA
ctattcTCAGAGA
ctattCTCAGAGA
ctaTTCTCAGAga
ctatTCTCAGAga
ctattCTCAGAGA
ctATTCTCAgaga
ctatTCTCAGAga
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
 -0.139
-0.147
-0.406
-0.278
-0.121
-0.395
-0.14
-0.119
C hsa-miR-204-3p
hsa-miR-3191-5p
hsa-miR-3192-5p
hsa-miR-326
hsa-miR-330-5p
hsa-miR-4314
hsa-miR-4646-5p
hsa-miR-518c-5p
hsa-miR-619-5p
hsa-miR-6506-5p
hsa-miR-6716-5p
hsa-miR-6764-3p
hsa-miR-6824-3p
16
17
16
17
17
16
16
17
16
16
17
17
17
 ctaTTCCCAGAga
ctattcCCAGAGA
ctatTCCCAGAga
ctattCCCAGAGA
ctattCCCAGAGA
ctatTCCCAGAga
ctaTTCCCAGAga
ctattcCCAGAGA
ctatTCCCAGAga
ctatTCCCAGAga
ctATTCCCAgaga
ctattcCCAGAGA
ctattcCCAGAGA
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
N
N
N
 -0.356
-0.216
-0.149
-0.457
-0.447
-0.276
-0.367
-0.168
-0.148
-0.158
-0.104
-0.173
-0.173
73686846 rs41286090 G G hsa-miR-640
13
 tgatTGGATCAcg
 Disrupted
N
 -0.098
A hsa-miR-4705
8
 TGATTGAatcacg
 Created
N
 -0.078
73688486 rs187117987 G G hsa-miR-10b-3p
4
 GAATCTGcttcag
 Disrupted
N
 -0.002
C hsa-miR-1252-5p
hsa-miR-4428
hsa-miR-6888-5p
3
4
4
 gaatcTCCTTCAg
gaaTCTCCTTcag
gaATCTCCTtcag
 Created
Created
Created
N
N
N
 0.029
-0.008
-0.013
73689249 rs4883946 A C hsa-miR-340-3p
hsa-miR-6827-3p
0 ggGAGACGGAaat
ggGAGACGGAaat
 Created
Created
N
N
 -0.142
-0.142
A hsa-miR-1237-3p
hsa-miR-1248
hsa-miR-4713-5p
hsa-miR-629-3p
hsa-miR-6867-3p
hsa-miR-6868-3p
0 gggAGAAGGAaat
gggAGAAGGAaat
GGGAGAAggaaat
GGGAGAAggaaat
GGGAGAAggaaat
gggAGAAGGAAat
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 0.046
0.051
-0.009
0.01
-0.038
0.068
73689772 rs184771263 C C hsa-miR-147b
hsa-miR-210-3p
hsa-miR-5707
hsa-miR-6854-3p
2
2
1
2
 atcaaaCGCACAA
atcaaACGCACAA
aTCAAACGcacaa
atcAAACGCAcaa
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.117
-0.22
-0.083
-0.055
73690323 rs41286094 G G hsa-miR-5092
2
 gctGTGGATAtgg
 Disrupted
N
 -0.002
C hsa-miR-501-3p
hsa-miR-502-3p
2
2
 gctGTGCATAtgg
gctGTGCATAtgg
 Created
Created
N
N
 0.027
0.027
73691774 rs149810759 A A hsa-miR-382-3p
7
 aGAATGATAacat
 Disrupted
N
 0.026
G hsa-miR-6512-5p
7
 agAATGGTAacat
 Created
N
 0.02
73691907 rs9543429 G G hsa-miR-4485
hsa-miR-570-3p
1
2
 aaGGCCGTTttca
aaggccGTTTTCA
 Disrupted
Disrupted
N
N
 -0.213
0.139
73693246 rs143388772 A A hsa-miR-421
hsa-miR-4709-5p
hsa-miR-4711-5p
hsa-miR-7112-3p
1
1
7
7
 CTGTTGAtgcatg
CTGTTGAtgcatg
ctgtTGATGCAtg
ctgtTGATGCAtg
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 0.067
0.071
0.03
0.017
G hsa-miR-501-3p
hsa-miR-502-3p
hsa-miR-767-5p
5
5
7
 ctgttGGTGCATg
ctgttGGTGCATg
ctgtTGGTGCAtg
 Created
Created
Created
N
N
N
 -0.015
-0.015
-0.009
73694488 rs77858334 A A hsa-miR-3140-3p
hsa-miR-627-3p
hsa-miR-629-3p
18
18
18
 ggagAAAAGCAat
ggAGAAAAGcaat
GGAGAAAagcaat
 Disrupted
Disrupted
Disrupted
N
N
N
 0.029
0.068
-0.005
G hsa-miR-5691
hsa-miR-6805-3p
hsa-miR-942-5p
18
18
19
 ggagaAGAGCAAt
ggagaAGAGCAAt
gGAGAAGAgcaat
 Created
Created
Created
N
N
N
 -0.041
-0.034
0.003
73695402 rs117431965 C C hsa-miR-2113
hsa-miR-3152-3p
hsa-miR-5010-3p
hsa-miR-599
12
12
13
13
 tgttaaCACAAAA
tgtTAACACAaaa
tgttaACACAAAA
tgttaACACAAAa
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.035
-0.087
-0.191
-0.059
T hsa-miR-3149
12
 tgttaATACAAAa
 Created
N
 -0.026

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