SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_024704
Gene Symbol:	KIF16B
Description:	Homo sapiens kinesin family member 16B (KIF16B), transcript variant 3, mRNA.
Gene Location:	chr20(-):16252748-16554079
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.16272534A>T			COSN10011857		C0031T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3122	attcTCCCAAatctaaatg	6	GUUGGGAC	m6b	Disrupted	-0.153000	-0.041000	0.440000
hsa-miR-376a-5p	attctcccaAATCTAaatg	8	GUAGAUUC	m6b	Disrupted	-0.150000	-0.144000	0.600000
hsa-miR-4760-5p	attctcccaAATCTAAAtg	0	UUUAGAUU	m8a	(m8a->m7a)	-0.098000	-0.004000	1.540000

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.16272770T>A			COSN8610507		2296_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-32-3p	atttTAAATTatttcattg	9	CAAUUUAG	m6b	Disrupted	0.119000	0.073000	0.020000
hsa-miR-5692a	attttaaATTATTTcattg	8	CAAAUAAU	m7b	Disrupted	0.100000	0.093000	0.460000
hsa-miR-944	attttaAATAATTTcattg	1	AAAUUAUU	m8a	Created	-0.064000	-0.093000	-0.240000

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.16272889T>G			COSN14484150		8067180		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3943	caaagtgGGGGGCTtacca	0	UAGCCCCC	m7b	Created	no TS	-0.245000	-8.610000
hsa-miR-4286	caaAGTGGGGggcttacca	0	ACCCCACU	m7b	(m6c->m7b)	no TS	-0.150000	-0.550000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
16272140	rs192362429	G	G	hsa-miR-4660 hsa-miR-7158-5p	15 11	taaattGAGCTGC taaATTGAGCtgc	Disrupted Disrupted	N N	-0.39 -0.261
			A	hsa-miR-32-3p hsa-miR-4775	10 11	TAAATTAagctgc tAAATTAAgctgc	Created Created	N N	-0.002 0.037
16272185	rs188054742	C	C	hsa-miR-1257 hsa-miR-183-3p hsa-miR-3650	11 1 13	ataATTCACAcca aTAATTCAcacca ataattCACACCA	Disrupted Disrupted Disrupted	N N N	-0.108 -0.122 -0.227
			A	hsa-miR-2053 hsa-miR-4694-5p hsa-miR-569 hsa-miR-944	11 11 11 1	ataATTAACAcca ataatTAACACCA ataATTAACAcca ATAATTAacacca	Created Created Created Created	N N N N	-0.164 -0.499 -0.059 -0.065
16272535	rs147757061	A	A	hsa-miR-1273h-5p hsa-miR-30b-3p hsa-miR-30c-1-3p hsa-miR-30c-2-3p hsa-miR-3122 hsa-miR-3689a-3p hsa-miR-3689b-3p hsa-miR-3689c hsa-miR-3913-5p hsa-miR-450a-1-3p hsa-miR-6513-5p hsa-miR-6731-5p hsa-miR-6779-5p hsa-miR-6780a-5p hsa-miR-6788-5p hsa-miR-6878-5p hsa-miR-8085 hsa-miR-887-5p	2 2 2 2 5 2 2 2 5 5 5 2 2 2 2 2 2 2	tCTCCCAAatcta tCTCCCAAatcta TCTCCCAAatcta TCTCCCAAatcta tcTCCCAAAtcta tCTCCCAAatcta tCTCCCAAatcta tCTCCCAAatcta tcTCCCAAAtcta tcTCCCAAAtcta tcTCCCAAAtcta TCTCCCAaatcta tCTCCCAAatcta tCTCCCAAatcta TCTCCCAAatcta TCTCCCAaatcta TCTCCCAaatcta tCTCCCAAAtcta	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N N N N N N N N	-0.133 -0.147 -0.39 -0.39 -0.112 -0.133 -0.133 -0.133 -0.14 -0.113 -0.109 -0.148 -0.13 -0.126 -0.369 -0.146 -0.148 -0.365
			G	hsa-miR-376a-5p hsa-miR-425-3p hsa-miR-6746-5p hsa-miR-6771-5p	11 5 2 2	tctcccGAATCTA tcTCCCGAAtcta TCTCCCGAatcta tCTCCCGAAtcta	Created Created Created Created	N N N N	-0.131 -0.251 -0.491 -0.527

Genome Browser