SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
  Home Search Help Download  

PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001146694
Gene Symbol: KDM4C
Description: Homo sapiens lysine (K)-specific demethylase 4C (KDM4C), transcript variant 2, mRNA.
Gene Location: chr9(+):6757640-7170920
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr9:g.7170070G>T COSN9318647 3584_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3679-3p caaaatcGGGGAAattaat
 2
 CUUCCCCC m6b Disrupted -0.189000 no TS 4.500000
hsa-miR-5096 caaaatcGGTGAAAttaat
 0 GUUUCACC m7b Created no TS -0.241000 -8.690000


Mutation Mutation ID Sample Name Cancer Type
chr9:g.7170121T>C COSN15316950 SNUH_G76_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr9:g.7170152A>G COSN1380501 HCC25T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr9:g.7170165G>A COSN14795065 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-181a-5p ttacTGAATGTgtgctctg
 0 AACAUUCA m7b Disrupted -0.215000 -0.125000 0.040000
hsa-miR-181b-5p ttacTGAATGTgtgctctg
 0 AACAUUCA m7b Disrupted -0.215000 -0.125000 0.060000
hsa-miR-181c-5p ttacTGAATGTgtgctctg
 0 AACAUUCA m7b Disrupted -0.215000 -0.125000 0.090000
hsa-miR-181d ttacTGAATGTgtgctctg
 0 AACAUUCA m7b Disrupted -0.215000 -0.125000 0.270000
hsa-miR-4262 ttacTGAATGTgtgctctg
 0 GACAUUCA m7b Disrupted -0.206000 -0.125000 1.170000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.7170857T>A COSN2325431 RK050_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1297 ggccaTACTTGAAgaagaa
 1
 UUCAAGUA m8a Disrupted -0.256000 no TS -1.580000
hsa-miR-26a-5p ggccaTACTTGAAgaagaa
 1
 UUCAAGUA m8a Disrupted -0.266000 no TS 3.310000
hsa-miR-26b-5p ggccaTACTTGAAgaagaa
 1
 UUCAAGUA m8a Disrupted -0.256000 no TS -1.080000
hsa-miR-325 ggccaTACTAGaagaagaa
 0 CCUAGUAG m6b Created no TS -0.113000 -3.620000
hsa-miR-4465 ggccaTACTTGAagaagaa
 1
 CUCAAGUA m7b Disrupted -0.266000 no TS 6.210000
hsa-miR-4659a-3p ggccatactAGAAGAAgaa
 1
 UUUCUUCU m7b (m6c->m7b) -0.297000 -0.443000 0.020000
hsa-miR-4659b-3p ggccatactAGAAGAAgaa
 1
 UUUCUUCU m7b (m6c->m7b) -0.297000 -0.443000 0.010000
hsa-miR-5697 ggccaTACTTGAagaagaa
 1
 UCAAGUAG m7a Disrupted -0.057000 no TS No effect
hsa-miR-628-3p ggccaTACTAGAagaagaa
 0 UCUAGUAA m7a Created no TS -0.094000 No effect
hsa-miR-676-5p ggccatacTTGAAGAagaa
 1
 UCUUCAAC m7a Disrupted -0.070000 no TS 0.350000
hsa-miR-1297 ggccaTACTTGAAgaagaa
 1
 UUCAAGUA m8a Disrupted -0.256000 no TS -1.580000
hsa-miR-26a-5p ggccaTACTTGAAgaagaa
 1
 UUCAAGUA m8a Disrupted -0.266000 no TS 3.310000
hsa-miR-26b-5p ggccaTACTTGAAgaagaa
 1
 UUCAAGUA m8a Disrupted -0.256000 no TS -1.080000
hsa-miR-325 ggccaTACTAGaagaagaa
 0 CCUAGUAG m6b Created no TS -0.113000 -3.620000
hsa-miR-4465 ggccaTACTTGAagaagaa
 1
 CUCAAGUA m7b Disrupted -0.266000 no TS 6.210000
hsa-miR-4659a-3p ggccatactAGAAGAAgaa
 1
 UUUCUUCU m7b (m6c->m7b) -0.297000 -0.443000 0.020000
hsa-miR-4659b-3p ggccatactAGAAGAAgaa
 1
 UUUCUUCU m7b (m6c->m7b) -0.297000 -0.443000 0.010000
hsa-miR-5697 ggccaTACTTGAagaagaa
 1
 UCAAGUAG m7a Disrupted -0.057000 no TS No effect
hsa-miR-628-3p ggccaTACTAGAagaagaa
 0 UCUAGUAA m7a Created no TS -0.094000 No effect
hsa-miR-676-5p ggccatacTTGAAGAagaa
 1
 UCUUCAAC m7a Disrupted -0.070000 no TS 0.350000
hsa-miR-1297 ggccaTACTTGAAgaagaa
 1
 UUCAAGUA m8a Disrupted -0.256 no TS -1.58
hsa-miR-26a-5p ggccaTACTTGAAgaagaa
 1
 UUCAAGUA m8a Disrupted -0.266 no TS 3.31
hsa-miR-26b-5p ggccaTACTTGAAgaagaa
 1
 UUCAAGUA m8a Disrupted -0.256 no TS -1.08
hsa-miR-325 ggccaTACTAGaagaagaa
 0 CCUAGUAG m6b Created no TS -0.113 -3.62
hsa-miR-4465 ggccaTACTTGAagaagaa
 1
 CUCAAGUA m7b Disrupted -0.266 no TS 6.21
hsa-miR-4659a-3p ggccatactAGAAGAAgaa
 0 UUUCUUCU m7b (m6c->m7b) -0.297 -0.443 0.02
hsa-miR-4659b-3p ggccatactAGAAGAAgaa
 0 UUUCUUCU m7b (m6c->m7b) -0.297 -0.443 0.01
hsa-miR-5697 ggccaTACTTGAagaagaa
 1
 UCAAGUAG m7a Disrupted -0.057 no TS No effect
hsa-miR-628-3p ggccaTACTAGAagaagaa
 0 UCUAGUAA m7a Created no TS -0.094 No effect
hsa-miR-676-5p ggccatacTTGAAGAagaa
 0 UCUUCAAC m7a Disrupted -0.07 no TS 0.35

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
7170165 rs3829103 G G hsa-miR-181a-5p
hsa-miR-181b-5p
hsa-miR-181c-5p
hsa-miR-181d-5p
hsa-miR-4262
1
1
1
1
1
 cTGAATGTgtgct
cTGAATGTgtgct
cTGAATGTgtgct
cTGAATGTgtgct
cTGAATGTgtgct
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.09
-0.09
-0.09
-0.09
-0.081
A hsa-miR-506-5p
hsa-miR-6074
hsa-miR-892c-5p
1
1
1
 CTGAATAtgtgct
cTGAATATgtgct
CTGAATAtgtgct
 Created
Created
Created
N
N
N
 -0.08
-0.052
-0.069
7170281 rs145482164 A A hsa-miR-4275
hsa-miR-4633-5p
2
1
 ggcaTAATTGAat
GGCATAAttgaat
 Disrupted
Disrupted
N
N
 0.005
-0.159
C hsa-miR-1297
hsa-miR-26a-5p
hsa-miR-26b-5p
hsa-miR-4465
hsa-miR-5697
2
2
2
2
2
 ggcaTACTTGAAt
ggcaTACTTGAAt
ggcaTACTTGAAt
ggcaTACTTGAAt
ggcaTACTTGAat
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.197
-0.197
-0.197
-0.197
-0.041

Genome Browser