SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_021161
Gene Symbol: KCNK10
Description: Homo sapiens potassium channel, subfamily K, member 10 (KCNK10), transcript variant 1, mRNA.
Gene Location: chr14(-):88646451-88793256
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr14:g.88180788T>C COSN1665561 RK056_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-199a-5p ataccttCACTGGacttca
7
CCCAGUGU m6b Created -0.049000 -0.115000 No effect
hsa-miR-199b-5p ataccttCACTGGacttca
7
CCCAGUGU m6b Created -0.049000 -0.118000 -0.050000
hsa-miR-5190 atacctTCACTGGacttca
0 CCAGUGAC m7a Created NA NA -0.110000
hsa-miR-199a-5p ataccttCACTGGacttca
0 CCCAGUGU m6b Created -0.049 -0.115 No effect
hsa-miR-199b-5p ataccttCACTGGacttca
0 CCCAGUGU m6b Created -0.049 -0.118 -0.05
hsa-miR-5190 atacctTCACTGGacttca
0 CCAGUGAC m7a Created NA NA -0.11

Mutation Mutation ID Sample Name Cancer Type
chr14:g.88181062T>G COSN15083325 LP6007422-DNA_A01 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-141-3p agcCAGTGTTgcattccac
0 UAACACUG m7b (m7b->m6c) 0.016000 no TS 2.520000
hsa-miR-200a-3p agcCAGTGTTgcattccac
0 UAACACUG m7b (m7b->m6c) 0.016000 no TS 4.140000
hsa-miR-3064-3p agccagTGTGGCAttccac
1
UUGCCACA m7b Created -0.212000 -0.276000 -0.050000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.88181093G>C COSN8460962 AOCS-078-1-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1303 agagcccCTCTAAAacgag
2
UUUAGAGA m7a Created 0.070000 0.106000 No effect
hsa-miR-3184-5p agaGCCCCTCtaaaacgag
0 UGAGGGGC m7b (m6c->m7b) no TS -0.205000 -6.320000
hsa-miR-423-5p agaGCCCCTCtaaaacgag
0 UGAGGGGC m7b (m6c->m7b) no TS -0.196000 No effect
hsa-miR-5095 agagccCCTGTAAaacgag
2
UUACAGGC m7a Disrupted 0.001000 no TS 3.520000
hsa-miR-877-5p agagccCCTCTAaaacgag
1
GUAGAGGA m6b Created 0.003000 -0.030000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.88181415G>A COSN15339437 SNU_WGS_02_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-147a cacacacaCACACACatac
0 GUGUGUGG m7a Created 0.023000 0.023000 -0.020000
hsa-miR-147b cacacacaCGCACACatac
0 GUGUGCGG m7a Disrupted NA NA 0.130000
hsa-miR-210 cacacacACGCACAcatac
0 CUGUGCGU m7b Disrupted -0.064000 no TS 2.620000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.88181419A>G COSN15610208 C0012T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-147a cacacaCACACACgcacac
0 GUGUGUGG m7a Disrupted 0.023000 0.023000 0.120000


Mutation Mutation ID Sample Name Cancer Type
chr14:g.88181927G>C COSN8460963 AOCS-166-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr14:g.88182680T>C COSN6263739 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-154-5p aacATAACCTtgggctggg
4
UAGGUUAU m7b (m7b->m6c) 0.090000 no TS 0.190000
hsa-miR-1915-3p aacataaCCCTGGGctggg
0 CCCCAGGG m7b Created -0.162000 -0.188000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.88183941C>A COSN5210835 SS6003323 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-302b-5p taccttTTAAAGagttcac
4
ACUUUAAC m6b Created 0.185000 0.352000 No effect
hsa-miR-302d-5p taccttTTAAAGagttcac
4
ACUUUAAC m6b Created 0.185000 0.359000 No effect
hsa-miR-3607-3p tacctTTTACAGagttcac
14
ACUGUAAA m7b Disrupted 0.030000 -0.149000 0.060000
hsa-miR-3664-5p taccttttACAGAGTTcac
1
AACUCUGU m8a Disrupted 0.013000 no TS 0.660000
hsa-miR-3686 taccttTTACAGAgttcac
13
AUCUGUAA m7b Disrupted -0.047000 -0.115000 0.800000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.88184956G>A COSN8460964 AOCS-114-1-8 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2115-5p ttgtTGGAAGCagatcaga
11
AGCUUCCA m7b Disrupted -0.275000 no TS 0.010000
hsa-miR-4686 ttgttggaAGCAGATcaga
0 UAUCUGCU m7b Disrupted -0.024000 0.073000 6.620000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.88185284G>A COSN8460965 AOCS-116-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4435 gttCTGGCCATacatgtta
0 AUGGCCAG m8a Created -0.022000 -0.236000 -0.010000
hsa-miR-548s gttcTGGCCATacatgtta
0 AUGGCCAA m7a Created -0.074000 -0.074000 -0.030000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
88180504 rs182857150 C C hsa-miR-6886-5p
2
taaCTGCGGAagc
Disrupted
N
-0.199
T hsa-miR-2115-5p
hsa-miR-3692-3p
1
2
taactgTGGAAGC
taacTGTGGAAgc
Created
Created
N
N
-0.148
-0.103
88181096 rs186714073 C C hsa-miR-4283
hsa-miR-5095
hsa-miR-6085
hsa-miR-6813-5p
hsa-miR-7151-3p
2
2
2
2
2
aGAGCCCCtgtaa
agagccCCTGTAA
agAGCCCCTgtaa
agAGCCCCTgtaa
agagccCCTGTAA
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
-0.223
0.001
-0.133
-0.152
-0.009
T hsa-miR-2467-5p
hsa-miR-4797-5p
2
2
aGAGCCTCtgtaa
agagcCTCTGTAa
Created
Created
N
N
-0.147
-0.013
88182157 rs184463086 G G hsa-miR-130b-5p
hsa-miR-3124-3p
hsa-miR-3180-5p
hsa-miR-665
2
3
2
2
ttcctgGAAAGAG
ttcctGGAAAGAg
ttcCTGGAAAgag
tTCCTGGAaagag
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
0.118
0.107
0.051
-0.009
T hsa-miR-4700-3p
hsa-miR-5095
hsa-miR-7151-3p
2
2
2
tTCCTGTAaagag
ttCCTGTAAagag
ttCCTGTAAagag
Created
Created
Created
N
N
N
0.002
0.035
0.028

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