SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_144633
Gene Symbol:	KCNH8
Description:	Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 8 (KCNH8), mRNA.
Gene Location:	chr3(+):19190016-19577135
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.19534203G>A			COSN1940071		RK035_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3167	caaagctgGAAATCCTgca	3	AGGAUUUC	m8a	Created	-0.082000	-0.166000	No effect
hsa-miR-3180-5p	caaagCTGGAAatcctgca	0	CUUCCAGA	m6b	Created	no TS	-0.089000	-2.410000
hsa-miR-4267	caaAGCTGGAaatcctgca	9	UCCAGCUC	m7a	(m6a->m7a)	-0.189000	-0.335000	0.040000
hsa-miR-876-5p	caaagctgGAAATCCtgca	3	UGGAUUUC	m7b	Created	-0.054000	-0.147000	No effect
hsa-miR-3167	caaagctgGAAATCCTgca	0	AGGAUUUC	m8a	Created	-0.082	-0.166	No effect
hsa-miR-3180-5p	caaagCTGGAAatcctgca	0	CUUCCAGA	m6b	Created	no TS	-0.089	-2.41
hsa-miR-4267	caaAGCTGGAaatcctgca	0	UCCAGCUC	m7a	(m6a->m7a)	-0.189	-0.335	0.04
hsa-miR-876-5p	caaagctgGAAATCCtgca	0	UGGAUUUC	m7b	Created	-0.054	-0.147	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.19534283G>A			COSN9543283		AOCS-117-3-3		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-103a-2-5p	tagatactAGAAGCataat	10	AGCUUCUU	m6b	Disrupted	-0.131000	no TS	7.200000
hsa-miR-3140-3p	tagatactAAAAGCataat	0	AGCUUUUG	m6b	Created	no TS	-0.063000	-0.670000
hsa-miR-325	tagaTACTAGaagcataat	1	CCUAGUAG	m6b	Disrupted	-0.120000	no TS	1.760000
hsa-miR-628-3p	tagaTACTAGAagcataat	1	UCUAGUAA	m7a	Disrupted	-0.108000	no TS	5.720000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.19534512G>A			COSN9718177		C0062T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-483-3p	ctcAGGAGTGcacagctcc	4	UCACUCCU	m7b	(m7b->m6b)	-0.107000	no TS	-0.750000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.19534655G>A			COSN14448219		8070199		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4307	aatgAAAACATctttattt	12	AAUGUUUU	m7b	Created	0.007000	0.008000	No effect
hsa-miR-4662b	aatgaaaaCATCTTTattt	0	AAAGAUGG	m7a	Created	NA	NA	-1.630000
hsa-miR-548u	aatgaaaacGTCTTTattt	14	CAAAGACU	m6b	Disrupted	-0.071000	no TS	1.410000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.19535064C>A			COSN6760869		RK211_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3692-5p	tcgttgtgCCAGCAGaaat	5	CCUGCUGG	m7b	Disrupted	-0.274000	no TS	0.110000
hsa-miR-4327	tcgttgTGCAAGCagaaat	0	GGCUUGCA	m7b	Created	no TS	-0.297000	-17.260000
hsa-miR-93-3p	tcgttgtgcCAGCAGaaat	5	ACUGCUGA	m6b	Disrupted	-0.095000	no TS	0.210000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.19535256A>G			COSN6760870		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-125b-2-3p	tgagctataACTTGTGgga	1	UCACAAGU	m7b	(m7b->m6c)	-0.312000	-0.161000	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.19535472G>A			COSN5532037		RK169_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-192-3p	ctgggATTGGCAatgattt	2	CUGCCAAU	m7b	Disrupted	-0.281000	no TS	7.590000
hsa-miR-4289	ctgggattgACAATGattt	0	GCAUUGUG	m6b	Created	no TS	-0.093000	0.190000
hsa-miR-4317	ctgggattGGCAATGattt	3	ACAUUGCC	m7b	Disrupted	-0.435000	no TS	1.740000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
19534602	rs184392002	G	G	hsa-miR-1226-3p hsa-miR-4267	8 9	aatagaGCTGGTG aataGAGCTGGtg	Disrupted Disrupted	N N	-0.169 -0.189
			A	hsa-miR-3168 hsa-miR-4277 hsa-miR-4482-3p	9 9 12	aaTAGAACTggtg aatAGAACTGgtg AATAGAActggtg	Created Created Created	N N N	-0.067 -0.104 0.024
19535068	rs181355551	A	A	hsa-miR-3692-5p hsa-miR-544a hsa-miR-5580-5p hsa-miR-6071 hsa-miR-6738-3p hsa-miR-6828-3p hsa-miR-93-3p	5 4 6 5 4 5 5	gCCAGCAGAaatg gccaGCAGAAAtg GCCAGCAgaaatg gcCAGCAGAAatg gccaGCAGAAAtg gccAGCAGAAatg gcCAGCAGAaatg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	-0.274 -0.03 -0.145 -0.228 -0.032 -0.061 -0.095
			G	hsa-miR-572 hsa-miR-718	5 4	gccAGCGGAAatg gccaGCGGAAAtg	Created Created	N N	-0.198 -0.168

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