SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_080671
Gene Symbol: KCNE4
Description: Homo sapiens potassium voltage-gated channel, Isk-related family, member 4 (KCNE4), mRNA.
Gene Location: chr2(+):223916861-223920355
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr2:g.223053487G>C COSN8985777 AOCS-117-3-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr2:g.223053568G>A COSN8608697 J10_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-132-5p gaaaaaGCCACGGagatgc
 0 ACCGUGGC m7b Created no TS -0.548000 -0.550000
hsa-miR-3119 gaAAAAGCCAcggagatgc
 0 UGGCUUUU m8a (m7a->m8a) -0.049000 -0.175000 No effect
hsa-miR-3605-3p gaaaaagcCACGGAGatgc
 0 CCUCCGUG m7b Created no TS -0.402000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.223053868A>G COSN1827744 RK012_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1224-3p ggatttttGGTGGGagaaa
 0 CCCCACCU m6b Created no TS -0.145000 -5.270000
hsa-miR-1260a ggatttttGGTGGGAgaaa
 0 AUCCCACC m7b Created no TS -0.219000 -0.460000
hsa-miR-1260b ggatttttGGTGGGAgaaa
 0 AUCCCACC m7b Created no TS -0.219000 -1.590000
hsa-miR-188-3p ggatttttgGTGGGAGaaa
 0 CUCCCACA m7a (m6b->m7a) NA NA -0.070000
hsa-miR-2116-3p ggatttttgATGGGAGaaa
 4
 CCUCCCAU m7b (m7b->m6c) -0.312000 -0.180000 1.100000
hsa-miR-3156-3p ggatttttgGTGGGAGaaa
 0 CUCCCACU m7a (m6b->m7a) NA NA -7.610000
hsa-miR-532-3p ggatttttgGTGGGAGaaa
 8
 CCUCCCAC m7b (m6c->m7b) -0.147000 -0.335000 0.050000
hsa-miR-1224-3p ggatttttGGTGGGagaaa
 0 CCCCACCU m6b Created no TS -0.145 -5.27
hsa-miR-1260a ggatttttGGTGGGAgaaa
 0 AUCCCACC m7b Created no TS -0.219 -0.46
hsa-miR-1260b ggatttttGGTGGGAgaaa
 0 AUCCCACC m7b Created no TS -0.219 -1.59
hsa-miR-188-3p ggatttttgGTGGGAGaaa
 0 CUCCCACA m7a (m6b->m7a) NA NA -0.07
hsa-miR-2116-3p ggatttttgATGGGAGaaa
 0 CCUCCCAU m7b (m7b->m6c) -0.312 -0.18 1.1
hsa-miR-3156-3p ggatttttgGTGGGAGaaa
 0 CUCCCACU m7a (m6b->m7a) NA NA -7.61
hsa-miR-532-3p ggatttttgGTGGGAGaaa
 0 CCUCCCAC m7b (m6c->m7b) -0.147 -0.335 0.05

Mutation Mutation ID Sample Name Cancer Type
chr2:g.223054276G>A COSN1827745 RK159_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-19a-3p gcggagaTTGCACAaagct
 6
 UGUGCAAA m7a Disrupted -0.212000 -0.217000 0.450000
hsa-miR-19b-3p gcggagaTTGCACAaagct
 6
 UGUGCAAA m7a Disrupted -0.212000 -0.217000 0.060000
hsa-miR-2113 gcggagattGCACAAAgct
 6
 AUUUGUGC m7b (m7b->m6c) -0.011000 no TS 2.610000
hsa-miR-5010-3p gcggagattACACAAAgct
 0 UUUUGUGU m7b (m6c->m7b) no TS 0.059000 -0.030000
hsa-miR-599 gcggagattACACAAagct
 0 GUUGUGUC m6b Created no TS 0.050000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.223054442G>A COSN5498506 RK118_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-374a-3p ggactctgTGATAAatatt
 10
 CUUAUCAG m6b Disrupted 0.069000 no TS 1.500000
hsa-miR-556-3p ggactctGTAATAaatatt
 0 AUAUUACC m6b Created no TS 0.070000 -4.820000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.223054655T>G COSN8558461 tumor_4135099 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-146a-5p tctgcaaAGTTCTCtggag
 4
 UGAGAACU m7b Disrupted -0.030000 no TS No effect
hsa-miR-146b-5p tctgcaaAGTTCTCtggag
 4
 UGAGAACU m7b Disrupted -0.030000 no TS No effect
hsa-miR-3121-5p tctGCAAAGGtctctggag
 0 UCCUUUGC m7b (m6b->m7b) no TS -0.044000 -0.130000
hsa-miR-3919 tctgcaaagTTCTCTGgag
 0 GCAGAGAA m7b (m7b->m6c) 0.023000 no TS 0.010000
hsa-miR-3925-5p tctgcaaaGTTCTCTggag
 0 AAGAGAAC m7b Disrupted -0.031000 no TS No effect
hsa-miR-769-5p tctgcaaAGGTCTCtggag
 1
 UGAGACCU m7b Created -0.089000 -0.176000 -0.960000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.223054849A>G COSN5498507 RK095_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4775 aaaAAAATTAtttatttat
 1
 UUAAUUUU m7b (m7b->m6b) -0.031000 no TS 0.020000
hsa-miR-5692a aaaaaaATTATTTatttat
 0 CAAAUAAU m7b Disrupted 0.121000 0.106000 1.220000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.223054949C>A COSN6171523 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273d ctccacctcATGGGTTtca
 0 GAACCCAU m7b (m6c->m7b) -0.105000 -0.156000 -7.720000
hsa-miR-3689d ctcCACCTCCtgggtttca
 1
 GGGAGGUG m7b (m7b->m6b) -0.425000 -0.353000 -0.010000
hsa-miR-4459 ctccaCCTCCTGGgtttca
 0 CCAGGAGG m8a Disrupted -0.519000 -0.401000 0.650000
hsa-miR-665 ctccacCTCCTGGgtttca
 0 ACCAGGAG m7b Disrupted -0.474000 -0.379000 -0.070000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
223053566 rs41311845 C C hsa-miR-3119
10
 aAAAAGCCgcgga
 Disrupted
N
 -0.049
223054386 rs41313557 T C hsa-miR-6746-5p
hsa-miR-6771-5p
hsa-miR-6827-5p
0 ggCTCCCGAcgat
ggCTCCCGAcgat
GGCTCCCgacgat
 Created
Created
Created
N
N
N
 -0.082
-0.085
-0.115
T hsa-miR-4433-3p
hsa-miR-4459
hsa-miR-4768-3p
0 ggCTCCTGAcgat
ggCTCCTGAcgat
ggCTCCTGAcgat
 Disrupted
Disrupted
Disrupted
N
N
N
 0.014
0.027
0.017
223054852 rs111373883 T T hsa-miR-5692a
1
 ATTATTTAtttat
 Disrupted
N
 0.122
G hsa-miR-551b-5p
hsa-miR-95-5p
1
1
 attaTTGATTTAt
aTTATTGAtttat
 Created
Created
N
N
 -0.053
0.001
223054864 rs72260983 - - hsa-miR-5692a
0 ttATTATTTttta
 Unknown
N
 -0.001
T
223055088 rs201828992 C C hsa-miR-4477b
hsa-miR-4753-5p
hsa-miR-7856-5p
1
1
1
 tcctggCCTTAAA
tccTGGCCTTAaa
tcctggCCTTAAA
 Disrupted
Disrupted
Disrupted
N
N
N
 0.011
-0.257
0.045
A hsa-miR-665
2
 TCCTGGActtaaa
 Created
N
 -0.146
223055622 rs190526737 C C hsa-miR-1915-3p
hsa-miR-4459
hsa-miR-4726-3p
hsa-miR-4779
hsa-miR-665
hsa-miR-6764-5p
hsa-miR-6797-5p
hsa-miR-6840-3p
2
2
2
2
2
2
2
2
 ttccctCCTGGGA
ttcCCTCCTGgga
ttccctCCTGGGA
ttCCCTCCTggga
ttccCTCCTGGga
ttccctCCTGGGA
tTCCCTCCtggga
ttcccTCCTGGGA
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
 -0.176
-0.214
-0.19
-0.298
-0.215
-0.18
-0.317
-0.404
T hsa-miR-3154
hsa-miR-7515
2
2
 ttCCCTTCTggga
tTCCCTTCtggga
 Created
Created
N
N
 -0.257
-0.297

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