SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_012281
Gene Symbol: KCND2
Description: Homo sapiens potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2), mRNA.
Gene Location: chr7(+):119913721-120390387
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr7:g.120747882G>A cosmic_v64_1675361 Melanoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5571-5p ggtctaaGAGAATTcgagc
 9
 CAAUUCUC m7b Disrupted -0.099 -0.002 0.33

Mutation Mutation ID Sample Name Cancer Type
chr7:g.120747975G>- ICGC_ssm_v3_67552 HCC123T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4999-3p aagaaggttGGTAGTGAaa
 0 UCACUACC m8a (m8a->m7b) -0.446000 -0.148000 0.050000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.120748127A>T COSN7652346 PCSI_0218_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3653 atgCTTCTTAtgatcagaa
 14
 CUAAGAAG m7b (m7b->m6b) -0.081000 -0.035000 0.260000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.120748140T>G COSN8515292 951_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548ac tcagaactcGTTTTTaata
 2
 CAAAAACC m6b Created 0.089000 0.106000 -0.920000
hsa-miR-548ad tcagaacTCGTTTTtaata
 0 GAAAACGA m7b Created no TS -0.182000 -0.060000
hsa-miR-548ae tcagaactcGTTTTTaata
 2
 CAAAAACU m6b Created 0.059000 0.076000 -0.030000
hsa-miR-548ah-3p tcagaactcGTTTTTaata
 2
 CAAAAACU m6b Created 0.070000 0.080000 -0.040000
hsa-miR-548aj-3p tcagaactcGTTTTTAata
 2
 UAAAAACU m7a (m6b->m7a) 0.059000 0.076000 -0.030000
hsa-miR-548am-3p tcagaactcGTTTTTaata
 2
 CAAAAACU m6b Created 0.070000 0.080000 -0.030000
hsa-miR-548aq-3p tcagaactcGTTTTTaata
 2
 CAAAAACU m6b Created 0.059000 0.076000 -0.030000
hsa-miR-548d-3p tcagaactcGTTTTTaata
 2
 CAAAAACC m6b Created 0.089000 0.096000 -0.100000
hsa-miR-548h-3p tcagaactcGTTTTTaata
 2
 CAAAAACC m6b Created 0.093000 0.107000 -0.040000
hsa-miR-548x-3p tcagaactcGTTTTTAata
 2
 UAAAAACU m7a (m6b->m7a) 0.059000 0.076000 -0.040000
hsa-miR-548z tcagaactcGTTTTTaata
 2
 CAAAAACC m6b Created 0.093000 0.107000 -0.040000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.120748639T>G 9_90974 CRC-8-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3613-3p atcaggatTTTTTTGTtgt
 11
 ACAAAAAA m8a Disrupted 0.232 0.16 0.05
hsa-miR-4668-3p atcaGGATTTTtttgttgt
 18
 GAAAAUCC m7b Disrupted -0.031 no TS 0.04
hsa-miR-548c-3p atcagGATTTTTttgttgt
 14
 CAAAAAUC m7b Disrupted 0.205 0.111 0.01

Mutation Mutation ID Sample Name Cancer Type
chr7:g.120748994T>A COSN14647363 ASHPC_0002_Pa_P_4 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1245a taaattATCACTaacgtct
 4
 AAGUGAUC m6b Created -0.011000 -0.020000 -0.060000
hsa-miR-1303 taaattaTCTCTAAcgtct
 5
 UUUAGAGA m7b Disrupted -0.015000 no TS 13.590000
hsa-miR-921 taaattaTCACTAacgtct
 0 CUAGUGAG m6b Created no TS -0.011000 -0.520000
hsa-miR-1245a taaattATCACTaacgtct
 4
 AAGUGAUC m6b Created -0.011000 -0.020000 -0.060000
hsa-miR-1303 taaattaTCTCTAAcgtct
 5
 UUUAGAGA m7b Disrupted -0.015000 no TS 13.590000
hsa-miR-921 taaattaTCACTAacgtct
 0 CUAGUGAG m6b Created no TS -0.011000 -0.520000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.120749071G>A COSN9824928 AOCS-141-3-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-145-5p attgACTGGAactaatatc
 0 GUCCAGUU m6b Created no TS -0.041000 -0.030000
hsa-miR-2114-5p attgactGGGACTAatatc
 0 UAGUCCCU m7a Disrupted -0.077000 no TS No effect
hsa-miR-5195-3p attgACTGGAactaatatc
 0 AUCCAGUU m6b Created no TS -0.047000 No effect
hsa-miR-5588-3p attgacTGGGACTaatatc
 0 AAGUCCCA m7b Disrupted -0.164000 no TS 2.110000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.120749689A>G COSN6347757 RK187_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4724-3p ctgagtGAAGGTAagataa
 0 GUACCUUC m7b Created no TS -0.288000 -11.040000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
120748636 rs13238427 - A hsa-miR-4668-3p
hsa-miR-548c-3p
16
16
 atcaGGATTTTtt
atcagGATTTTTt
 Unknown
Unknown
N
N
 -0.031
0.094
T hsa-miR-548ac
hsa-miR-548d-3p
hsa-miR-548h-3p
hsa-miR-548z
16
16
16
16
 atcaGGTTTTTtt
atcaGGTTTTTtt
atcaGGTTTTTtt
atcaGGTTTTTtt
 Unknown
Unknown
Unknown
Unknown
N
N
N
N
 -0.035
-0.035
-0.026
-0.026
120749039 rs188247260 T T hsa-miR-1245a
hsa-miR-3689a-5p
hsa-miR-3689b-5p
hsa-miR-3689e
hsa-miR-3689f
hsa-miR-8062
hsa-miR-8079
4
4
4
4
4
4
4
 gatatATCACTAt
gatATATCACtat
gatATATCACtat
gatATATCACtat
gatATATCACtat
gatatATCACTAt
gatatATCACTAt
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.011
-0.067
-0.067
-0.067
-0.067
-0.006
-0.014
G hsa-miR-4473
hsa-miR-512-3p
hsa-miR-520f-3p
4
4
4
 gatatAGCACTAt
gatatAGCACTAt
gatatAGCACTAt
 Created
Created
Created
N
N
N
 -0.127
-0.035
-0.053

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