SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_020433
Gene Symbol: JPH2
Description: Homo sapiens junctophilin 2 (JPH2), transcript variant 1, mRNA.
Gene Location: chr20(-):42740336-42816218
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr20:g.44112214T>C JPH2_E6_UTR_3 SJLGG037_D [central_nervous_system][brain][glioma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-15a-5p aacTGCTGCTgtcctccct
 0 UAGCAGCA m7b (m7b->m6c) -0.082 no TS 0.21
hsa-miR-15b-5p aacTGCTGCTgtcctccct
 0 UAGCAGCA m7b (m7b->m6c) -0.082 no TS 0.32
hsa-miR-16-5p aacTGCTGCTgtcctccct
 0 UAGCAGCA m7b (m7b->m6c) -0.072 no TS 0.23
hsa-miR-195-5p aacTGCTGCTgtcctccct
 0 UAGCAGCA m7b (m7b->m6c) -0.072 no TS 0.34
hsa-miR-424-5p aacTGCTGCTGtcctccct
 0 CAGCAGCA m8a Disrupted -0.063 no TS 0.13
hsa-miR-497-5p aacTGCTGCTGtcctccct
 0 CAGCAGCA m8a Disrupted -0.082 no TS 0.51
hsa-miR-5004-5p aactgctgcTGTCCTCcct
 0 UGAGGACA m7b (m7b->m6b) -0.067 no TS No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
44112220 rs150285701 T T hsa-miR-15a-5p
hsa-miR-15b-5p
hsa-miR-16-5p
hsa-miR-195-5p
hsa-miR-424-5p
hsa-miR-497-5p
hsa-miR-584-3p
hsa-miR-6838-5p
2
2
2
2
2
2
4
2
 gggaacTGCTGCT
gggaacTGCTGCT
gggaacTGCTGCT
gggaacTGCTGCT
gggaacTGCTGCT
gggaacTGCTGCT
gGGAACTGctgct
gggaacTGCTGCT
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
 -0.082
-0.082
-0.072
-0.072
-0.063
-0.082
-0.045
-0.063
A hsa-miR-642b-5p
hsa-miR-646
4
2
 GGGAACAgctgct
gggaacAGCTGCT
 Created
Created
N
N
 -0.11
-0.117

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