SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_002223
Gene Symbol: ITPR2
Description: Homo sapiens inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2), mRNA.
Gene Location: chr12(-):26488284-26986131
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr12:g.26335778A>C COSN7324761 8034061 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-17-3p gcacaccaACTGCAGggat
 0 ACUGCAGU m7b Created no TS -0.119000 No effect
hsa-miR-20a-3p gcacaccaAATGCAGggat
 1
 ACUGCAUU m7b Disrupted -0.104000 -0.022000 0.150000
hsa-miR-5002-5p gcacACCAAATgcagggat
 1
 AAUUUGGU m7b Disrupted 0.040000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.26335783A>G COSN7613624 PCSI_0164_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3650 gaggtgCACACCaaatgca
 3
 AGGUGUGU m6b Disrupted -0.295000 -0.185000 No effect
hsa-miR-5002-5p gaggtgcacACCAAATgca
 1
 AAUUUGGU m7b (m7b->m6b) 0.040000 no TS No effect


Mutation Mutation ID Sample Name Cancer Type
chr12:g.26336086G>A COSN14853478 LP6005334-DNA_C03 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr12:g.26336418T>A COSN7324762 8036161 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-138-1-3p cacaatttcAAGTAGattg
 6
 GCUACUUC m6b Created 0.076000 0.060000 No effect
hsa-miR-203 cacaATTTCAagtagattg
 7
 GUGAAAUG m6b Created 0.221000 0.330000 -0.010000
hsa-miR-28-3p cacaattTCTAGTagattg
 4
 CACUAGAU m6b Disrupted -0.043000 no TS 4.020000
hsa-miR-5680 cacaATTTCTagtagattg
 1
 GAGAAAUG m6b Disrupted 0.111000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.26337663G>A COSN8707354 AOCS-058-1-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3166 gataTGTCTGCatgcagca
 2
 CGCAGACA m7b Disrupted -0.068000 no TS 0.170000
hsa-miR-3668 gatatgTCTACATgcagca
 0 AAUGUAGA m7b Created no TS 0.005000 -1.590000
hsa-miR-4666b gatatgtctACATGCAgca
 0 UUGCAUGU m7b (m6b->m7b) no TS 0.019000 0.260000
hsa-miR-4771 gatatGTCTGCatgcagca
 2
 AGCAGACU m6b Disrupted -0.041000 no TS 5.390000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.26338675T>C COSN8707355 AOCS-167-13-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4773 aacaTGTTCTaagtcatgt
 1
 CAGAACAG m6b Disrupted 0.037000 0.061000 0.010000
hsa-miR-890 aacatgtTCCAAGTcatgt
 0 UACUUGGA m7b Created no TS -0.153000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.26338814A>G COSN14666861 8051707 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-384 tacagctCTAGGAActtag
 7
 AUUCCUAG m7b Disrupted -0.115000 0.007000 0.120000
hsa-miR-5571-3p tacagctCTAGGAacttag
 7
 GUCCUAGG m6b Disrupted -0.118000 -0.043000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
26336771 rs11048471 A A hsa-miR-33a-5p
hsa-miR-33b-5p
3
3
 AATGCAAtcatct
AATGCAAtcatct
 Disrupted
Disrupted
N
N
 0.021
0.021
G hsa-miR-20a-3p
hsa-miR-217
hsa-miR-5002-3p
hsa-miR-6807-3p
3
3
4
3
 AATGCAGtcatct
aATGCAGTcatct
aatGCAGTCAtct
aATGCAGTcatct
 Created
Created
Created
Created
N
N
N
N
 -0.032
-0.074
-0.082
-0.074

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