SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_016358
Gene Symbol:	IRX4
Description:	Homo sapiens iroquois homeobox 4 (IRX4), mRNA.
Gene Location:	chr5(-):1877540-1882880
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.1877475C>T			COSN8210258		PCSI_0083_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3166	caataatTGTCTGCttcag	0	CGCAGACA	m7b	Created	no TS	-0.290000	-3.820000
hsa-miR-4690-5p	caataattGCCTGCTtcag	9	GAGCAGGC	m7b	Disrupted	-0.353000	no TS	1.470000
hsa-miR-4742-5p	caataaTTGCCTGcttcag	10	UCAGGCAA	m7b	Disrupted	-0.267000	no TS	1.580000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.1877796C>T			COSN1313312		HCC72T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3622b-5p	gcgctgCCATGCCggggcc	0	AGGCAUGG	m7b	Created	no TS	-0.061000	-11.800000
hsa-miR-4304	gcgctgcCATGCCGGggcc	0	CCGGCAUG	m8a	Created	no TS	-0.155000	-5.120000
hsa-miR-3622b-5p	gcgctgCCATGCCggggcc	0	AGGCAUGG	m7b	Created	no TS	-0.061000	-11.800000
hsa-miR-4304	gcgctgcCATGCCGGggcc	0	CCGGCAUG	m8a	Created	no TS	-0.155000	-5.120000
hsa-miR-3622b-5p	gcgctgCCATGCCggggcc	0	AGGCAUGG	m7b	Created	no TS	-0.061	-11.8
hsa-miR-4304	gcgctgcCATGCCGGggcc	0	CCGGCAUG	m8a	Created	no TS	-0.155	-5.12

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.1877888G>A			COSN15116813		LP6005690-DNA_C02		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1238	ccaGAGGAAGactagcgcg	0	CUUCCUCG	m7a	(m7a->m6b)	no TS	-0.083000	-0.370000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.1877907C>T			COSN14945850		CHC433T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4276	gactctttTCACTGAGttt	0	CUCAGUGA	m8a	Disrupted	-0.158000	no TS	0.010000
hsa-miR-4797-3p	gactcttttTACTGAGttt	0	UCUCAGUA	m7b	(m6b->m7b)	no TS	-0.167000	-2.010000
hsa-miR-5190	gactctttTCACTGagttt	0	CCAGUGAC	m6b	Disrupted	-0.087000	no TS	10.510000
hsa-miR-545-5p	gactcttTTTACTGAgttt	0	UCAGUAAA	m8a	Created	no TS	-0.146000	5.160000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.1877921G>A			COSN6585098		ICGC_MB66		[central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1469	aggcggacgGCGCCGActc	2	CUCGGCGC	m7b	(m7b->m6b)	-0.363000	no TS	1.060000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
1877907	rs2279588	T	C	hsa-miR-4276 hsa-miR-5190	0	tctttTCACTGAg tctttTCACTGAg	Created Created	N N	-0.158 -0.087
			T	hsa-miR-4797-3p hsa-miR-545-5p	1 0	tcttttTACTGAG tcttTTTACTGAg	Disrupted Disrupted	N N	-0.167 -0.146

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