SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
  Home Search Help Download  

PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_033267
Gene Symbol: IRX2
Description: Homo sapiens iroquois homeobox 2 (IRX2), transcript variant 2, mRNA.
Gene Location: chr5(-):2746278-2751769
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr5:g.2746468G>T COSN2098674 RK001_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1228-3p tattctatAGGTGTGAtag
 18
 UCACACCU m8a Disrupted -0.390000 no TS 3.890000
hsa-miR-377-3p tattctataTGTGTGATag
 11
 AUCACACA m8a (m7a->m8a) -0.171000 -0.396000 0.060000
hsa-miR-4789-3p tattctaTATGTGTGatag
 1
 CACACAUA m8a Created -0.347000 -0.521000 -0.200000
hsa-miR-1228-3p tattctatAGGTGTGAtag
 0 UCACACCU m8a Disrupted -0.39 no TS 3.89
hsa-miR-377-3p tattctataTGTGTGATag
 0 AUCACACA m8a (m7a->m8a) -0.171 -0.396 0.06
hsa-miR-4789-3p tattctaTATGTGTGatag
 0 CACACAUA m8a Created -0.347 -0.521 -0.2

Mutation Mutation ID Sample Name Cancer Type
chr5:g.2746526C>T COSN9430241 AOCS-088-3-8 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4445-5p gaaAACAATCTgtttttct
 0 AGAUUGUU m8a Disrupted -0.136000 no TS 1.990000
hsa-miR-7-1-3p gaaaacaATTTGTTtttct
 8
 CAACAAAU m7b Created 0.021000 -0.029000 -0.010000
hsa-miR-7-2-3p gaaaacaATTTGTTtttct
 8
 CAACAAAU m7b Created 0.021000 -0.029000 -0.040000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.2746548A>G COSN2098677 RK010_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4789-3p ccccgatgTATGTGTGact
 1
 CACACAUA m8a Disrupted -0.347000 -0.301000 -0.270000
hsa-miR-603 ccccgatgtGTGTGTGact
 2
 CACACACU m7a (m6a->m7a) -0.131000 -0.131000 -7.900000
hsa-miR-4789-3p ccccgatgTATGTGTGact
 1
 CACACAUA m8a Disrupted -0.347000 -0.301000 -0.270000
hsa-miR-603 ccccgatgtGTGTGTGact
 2
 CACACACU m7a (m6a->m7a) -0.131000 -0.131000 -7.900000
hsa-miR-4789-3p ccccgatgTATGTGTGact
 0 CACACAUA m8a Disrupted -0.347 -0.301 -0.27
hsa-miR-603 ccccgatgtGTGTGTGact
 0 CACACACU m7a (m6a->m7a) -0.131 -0.131 -7.9

Mutation Mutation ID Sample Name Cancer Type
chr5:g.2746603C>G COSN2098679 RK177_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1236 caattGGAAGAGactattg
 8
 CCUCUUCC m7b Created -0.034000 -0.348000 -0.070000
hsa-miR-26b-3p caattgGAACAGactattg
 2
 CCUGUUCU m6b Disrupted -0.085000 no TS 0.680000
hsa-miR-4474-5p caattggaaGAGACTAttg
 0 UUAGUCUC m7b (m6b->m7b) no TS -0.196000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.2746822G>A COSN8492624 824_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-30a-3p gaACTGAAAGattggggat
 0 CUUUCAGU m8a (m8a->m7b) -0.005000 -0.059000 No effect
hsa-miR-30d-3p gaACTGAAAGattggggat
 0 CUUUCAGU m8a (m8a->m7b) -0.005000 -0.059000 No effect
hsa-miR-30e-3p gaACTGAAAGattggggat
 0 CUUUCAGU m8a (m8a->m7b) -0.014000 -0.070000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.2746830A>G COSN8492625 1920_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-188-3p ttgtTGTGGGActgaaaga
 0 CUCCCACA m7b Created no TS -0.150000 No effect
hsa-miR-1910 ttgttgtgGGACTGaaaga
 0 CCAGUCCU m6b Created no TS -0.119000 -0.700000
hsa-miR-3692-3p ttgtTGTGGAACtgaaaga
 18
 GUUCCACA m8a Disrupted -0.258000 -0.125000 1.420000
hsa-miR-4277 ttgttgtgGAACTGaaaga
 0 GCAGUUCU m6b Disrupted -0.069000 no TS 0.450000
hsa-miR-4433-5p ttgttGTGGGACtgaaaga
 0 CGUCCCAC m7b Created no TS -0.245000 -6.170000
hsa-miR-455-3p ttgttgtgGGACTGaaaga
 0 GCAGUCCA m6b Created no TS -0.124000 -5.340000
hsa-miR-5588-3p ttgttgTGGGACTgaaaga
 0 AAGUCCCA m7b Created no TS -0.161000 -3.310000
hsa-miR-584-3p ttgttgtGGAACTGAaaga
 0 UCAGUUCC m8a Disrupted -0.310000 no TS 1.490000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.2747180G>A COSN8222788 PCSI_0072_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-198 aaaaTCTGGACatttatat
 0 GGUCCAGA m7b Created no TS -0.467000 -0.310000
hsa-miR-365a-3p aaaatctGGGCATTtatat
 4
 UAAUGCCC m7b Disrupted -0.302000 no TS 1.830000
hsa-miR-365b-3p aaaatctGGGCATTtatat
 4
 UAAUGCCC m7b Disrupted -0.302000 no TS 1.830000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.2747456T>A COSN1314402 HCC115T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4780 ttctggTCAAGGGgttaga
 0 ACCCUUGA m7b Created no TS -0.188000 -7.420000
hsa-miR-5195-5p ttctggtcaAGGGGTTaga
 0 AACCCCUA m7a (m6a->m7a) NA NA -10.060000
hsa-miR-4780 ttctggTCAAGGGgttaga
 0 ACCCUUGA m7b Created no TS -0.188000 -7.420000
hsa-miR-5195-5p ttctggtcaAGGGGTTaga
 0 AACCCCUA m7a (m6a->m7a) NA NA -10.060000
hsa-miR-4780 ttctggTCAAGGGgttaga
 0 ACCCUUGA m7b Created no TS -0.188000 -7.420000
hsa-miR-5195-5p ttctggtcaAGGGGTTaga
 0 AACCCCUA m7a (m6a->m7a) NA NA -10.060000
hsa-miR-4780 ttctggTCAAGGGgttaga
 0 ACCCUUGA m7b Created no TS -0.188 -7.42
hsa-miR-5195-5p ttctggtcaAGGGGTTaga
 0 AACCCCUA m7a (m6a->m7a) NA NA -10.06

Mutation Mutation ID Sample Name Cancer Type
chr5:g.2747528C>A COSN1314405 HCC32T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-199a-5p agtgggcACACTGGtgctt
 0 CCCAGUGU m7b Created no TS -0.131000 -0.010000
hsa-miR-199b-5p agtgggcACACTGGtgctt
 0 CCCAGUGU m7b Created no TS -0.131000 No effect
hsa-miR-4302 agtgggCACACTGGtgctt
 0 CCAGUGUG m8a Created no TS -0.082000 No effect
hsa-miR-4733-3p agtgggcacCCTGGTGctt
 4
 CCACCAGG m7b (m7b->m6b) -0.155000 no TS 0.170000
hsa-miR-648 agtggGCACACTggtgctt
 0 AAGUGUGC m7b Created -0.142000 -0.311000 -0.060000
hsa-miR-199a-5p agtgggcACACTGGtgctt
 0 CCCAGUGU m7b Created no TS -0.131000 -0.010000
hsa-miR-199b-5p agtgggcACACTGGtgctt
 0 CCCAGUGU m7b Created no TS -0.131000 No effect
hsa-miR-4302 agtgggCACACTGGtgctt
 0 CCAGUGUG m8a Created no TS -0.082000 No effect
hsa-miR-4733-3p agtgggcacCCTGGTGctt
 4
 CCACCAGG m7b (m7b->m6b) -0.155000 no TS 0.170000
hsa-miR-648 agtggGCACACTggtgctt
 0 AAGUGUGC m7b Created -0.142000 -0.311000 -0.060000
hsa-miR-199a-5p agtgggcACACTGGtgctt
 0 CCCAGUGU m7b Created no TS -0.131000 -0.010000
hsa-miR-199b-5p agtgggcACACTGGtgctt
 0 CCCAGUGU m7b Created no TS -0.131000 No effect
hsa-miR-4302 agtgggCACACTGGtgctt
 0 CCAGUGUG m8a Created no TS -0.082000 No effect
hsa-miR-4733-3p agtgggcacCCTGGTGctt
 4
 CCACCAGG m7b (m7b->m6b) -0.155000 no TS 0.170000
hsa-miR-648 agtggGCACACTggtgctt
 0 AAGUGUGC m7b Created -0.142000 -0.311000 -0.060000
hsa-miR-199a-5p agtgggcACACTGGtgctt
 0 CCCAGUGU m7b Created no TS -0.131 -0.01
hsa-miR-199b-5p agtgggcACACTGGtgctt
 0 CCCAGUGU m7b Created no TS -0.131 No effect
hsa-miR-4302 agtgggCACACTGGtgctt
 0 CCAGUGUG m8a Created no TS -0.082 No effect
hsa-miR-4733-3p agtgggcacCCTGGTGctt
 0 CCACCAGG m7b (m7b->m6b) -0.155 no TS 0.17
hsa-miR-648 agtggGCACACTggtgctt
 0 AAGUGUGC m7b Created -0.142 -0.311 -0.06

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
2746546 rs28712785 G G hsa-miR-377-3p
hsa-miR-4789-3p
11
9
 atgtaTGTGTGAc
atgTATGTGTgac
 Disrupted
Disrupted
N
N
 -0.171
-0.046
2747143 rs142895789 A A hsa-miR-4711-3p
hsa-miR-8078
6
4
 tatgctAGACACA
tatgCTAGACAca
 Disrupted
Disrupted
N
N
 -0.102
-0.143
G hsa-miR-198
hsa-miR-338-3p
hsa-miR-3657
hsa-miR-4530
hsa-miR-4669
4
2
6
3
6
 tatgCTGGACAca
tATGCTGGAcaca
tatgctGGACACA
taTGCTGGAcaca
tatgctGGACACA
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.154
-0.333
-0.149
-0.125
-0.167
2747289 rs113300568 - GT hsa-miR-329-3p
hsa-miR-362-3p
hsa-miR-3941
hsa-miR-466
hsa-miR-4672
hsa-miR-603
hsa-miR-6504-3p
hsa-miR-656-3p
2
2
2
2
2
2
2
2
 gtGTGTGTAatatat
gtGTGTGTAatatat
gtGTGTGTAAtatat
gtgTGTGTAAtatat
gtgTGTGTAAtatat
gtGTGTGTAatatat
gtgtgTGTAATAtat
gtgtgtgTAATATAt
 Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
N
N
 0.003
0.003
0.006
0.001
0.004
0.003
0.003
0.002
-

Genome Browser