SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_001195286
Gene Symbol: IRF4
Description: Homo sapiens interferon regulatory factor 4 (IRF4), transcript variant 2, mRNA.
Gene Location: chr6(+):391738-411443
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr6:g.407806G>A COSN2161948 RK032_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-19a-5p cccaccCAAAACaagtgat
0 AGUUUUGC m6b Created no TS -0.023000 No effect
hsa-miR-19b-1-5p cccaccCAAAACaagtgat
0 AGUUUUGC m6b Created no TS -0.023000 No effect
hsa-miR-19b-2-5p cccaccCAAAACaagtgat
0 AGUUUUGC m6b Created no TS -0.023000 No effect
hsa-miR-2052 cccaccCAAAACAagtgat
0 UGUUUUGA m7a Created no TS -0.015000 -0.010000
hsa-miR-431-5p cccaccCAAGACAagtgat
2
UGUCUUGC m7a Disrupted -0.095000 no TS No effect
hsa-miR-511 cccacccAAGACAagtgat
2
GUGUCUUU m6b Disrupted 0.008000 0.059000 No effect
hsa-miR-635 cccaCCCAAGacaagtgat
0 ACUUGGGC m6b Disrupted -0.110000 no TS 0.030000
hsa-miR-19a-5p cccaccCAAAACaagtgat
0 AGUUUUGC m6b Created no TS -0.023 No effect
hsa-miR-19b-1-5p cccaccCAAAACaagtgat
0 AGUUUUGC m6b Created no TS -0.023 No effect
hsa-miR-19b-2-5p cccaccCAAAACaagtgat
0 AGUUUUGC m6b Created no TS -0.023 No effect
hsa-miR-2052 cccaccCAAAACAagtgat
0 UGUUUUGA m7a Created no TS -0.015 -0.01
hsa-miR-431-5p cccaccCAAGACAagtgat
2
UGUCUUGC m7a Disrupted -0.095 no TS No effect
hsa-miR-511 cccacccAAGACAagtgat
2
GUGUCUUU m6b Disrupted 0.008 0.059 No effect
hsa-miR-635 cccaCCCAAGacaagtgat
0 ACUUGGGC m6b Disrupted -0.11 no TS 0.03

Mutation Mutation ID Sample Name Cancer Type
chr6:g.407904C>A COSN8514326 1953_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3545-3p atttCAGTTCAgcggttga
2
UUGAACUG m7b Disrupted -0.084000 0.049000 0.060000
hsa-miR-4539 atttcAGTTCAGCggttga
1
GCUGAACU m8a Disrupted 0.001000 0.072000 No effect
hsa-miR-4804-3p atttcaGTTAAGCggttga
0 UGCUUAAC m7b Created no TS -0.136000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.408206G>A COSN6320584 RK121_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-200a-5p aaGTAAGATGtaaattgaa
1
CAUCUUAC m8a (m8a->m7a) -0.087000 -0.175000 No effect
hsa-miR-200b-5p aaGTAAGATGtaaattgaa
1
CAUCUUAC m8a (m8a->m7a) -0.087000 -0.175000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.408445C>T COSN6320592 RK163_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3653 gtaaaCTTCTTAttttctt
0 CUAAGAAG m7b Created 0.179000 0.111000 -0.020000
hsa-miR-4476 gtaaaCTTCCTattttctt
1
CAGGAAGG m6b Disrupted -0.033000 0.007000 0.790000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.408577G>C COSN9783023 AOCS-094-1-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3675-3p ttcttTAGAGATGctaaaa
0 CAUCUCUA m8a Disrupted -0.047000 no TS 0.220000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.408962A>G COSN6320606 RK028_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3144-3p acttgcttAGGTATAccta
0 AUAUACCU m7b Created no TS 0.001000 -1.190000
hsa-miR-4503 actTGCTTAAgtataccta
10
UUUAAGCA m7b (m7b->m6b) 0.028000 no TS 1.870000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.409013C>G COSN9783043 AOCS-165-1-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4286 agcagtagAGTGGGGcgtc
0 ACCCCACU m7b Created no TS -0.011000 -4.990000
hsa-miR-4758-3p agcagtagaGTGGGGCgtc
0 UGCCCCAC m7b (m6c->m7b) no TS -0.103000 -5.150000
hsa-miR-934 agcAGTAGACtggggcgtc
1
UGUCUACU m7b (m7b->m6b) 0.072000 no TS 0.090000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.409318G>C COSN2161994 RK082_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2117 caaacagtAGAGAACAgca
4
UGUUCUCU m8a Disrupted -0.027000 -0.052000 0.010000
hsa-miR-3686 caaacagTACAGAacagca
1
AUCUGUAA m6b Created 0.063000 0.115000 -0.010000
hsa-miR-4273 caaacagtaGAGAACAgca
1
GUGUUCUC m7b (m7b->m6c) 0.001000 no TS 1.740000
hsa-miR-4652-3p caaacagtACAGAACagca
1
GUUCUGUU m7a Created 0.148000 0.148000 No effect
hsa-miR-4684-5p caaacaGTAGAGAacagca
8
CUCUCUAC m7b Disrupted 0.025000 0.039000 0.210000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.409602T>C COSN9783067 AOCS-148-1-4 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3676-3p catgcAACACGGatatgta
0 CCGUGUUU m7a Created NA NA -0.200000
hsa-miR-4716-5p catgcAACATGGAtatgta
0 UCCAUGUU m8a Disrupted 0.126000 no TS No effect
hsa-miR-4800-3p catgcaacACGGATatgta
0 CAUCCGUC m6b Created no TS -0.084000 -0.090000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.410024A>C COSN4927767 PD4115a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4725-5p atcCAGGGTCTgacctagg
0 AGACCCUG m8a Created no TS -0.055000 0.020000
hsa-miR-504 atcCAGGGTCTgacctagg
0 AGACCCUG m8a Created no TS -0.093000 -2.760000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.410514T>C COSN2162021 RK037_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-101-3p cttacaGTACTGTtaccac
0 UACAGUAC m7b Created no TS -0.061000 -1.140000
hsa-miR-1278 cttaCAGTACTgttaccac
0 UAGUACUG m7b Created no TS -0.081000 -0.440000
hsa-miR-194-5p cttacagtaCTGTTACcac
1
UGUAACAG m7b (m6c->m7b) -0.145000 -0.171000 No effect
hsa-miR-200b-3p cttaCAGTATTgttaccac
4
UAAUACUG m7b Disrupted -0.038000 -0.053000 0.010000
hsa-miR-200c-3p cttaCAGTATTgttaccac
4
UAAUACUG m7b Disrupted -0.047000 -0.053000 0.210000
hsa-miR-338-5p cttacagTATTGTTaccac
0 AACAAUAU m7a Disrupted NA NA 5.007000
hsa-miR-429 cttaCAGTATTgttaccac
4
UAAUACUG m7b Disrupted -0.038000 -0.053000 0.530000
hsa-miR-101-3p cttacaGTACTGTtaccac
0 UACAGUAC m7b Created no TS -0.061 -1.14
hsa-miR-1278 cttaCAGTACTgttaccac
0 UAGUACUG m7b Created no TS -0.081 -0.44
hsa-miR-194-5p cttacagtaCTGTTACcac
0 UGUAACAG m7b (m6c->m7b) -0.145 -0.171 No effect
hsa-miR-200b-3p cttaCAGTATTgttaccac
1
UAAUACUG m7b Disrupted -0.038 -0.053 0.01
hsa-miR-200c-3p cttaCAGTATTgttaccac
1
UAAUACUG m7b Disrupted -0.047 -0.053 0.21
hsa-miR-338-5p cttacagTATTGTTaccac
0 AACAAUAU m7a Disrupted NA NA 5.007
hsa-miR-429 cttaCAGTATTgttaccac
1
UAAUACUG m7b Disrupted -0.038 -0.053 0.53

Mutation Mutation ID Sample Name Cancer Type
chr6:g.410727C>T COSN4927771 PD4109a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3908 acttccgttCATTGCTCtc
2
GAGCAAUG m8a (m8a->m7b) -0.054000 no TS 2.110000
hsa-miR-3942-5p acttccgttTATTGCTctc
0 AAGCAAUA m7b (m6c->m7b) no TS -0.019000 0.050000
hsa-miR-4703-5p acttccgttTATTGCTctc
0 UAGCAAUA m7b (m6c->m7b) no TS -0.028000 -0.020000
hsa-miR-553 acttCCGTTTattgctctc
0 AAAACGGU m6b Created no TS -0.120000 -0.700000
hsa-miR-887 acttCCGTTCAttgctctc
0 GUGAACGG m7b Disrupted -0.215000 no TS 0.180000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.410998T>G COSN7882909 8035567 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-141-3p aaggtCAGTGTTtttttgt
0 UAACACUG m7b Created no TS -0.155000 -0.050000
hsa-miR-200a-3p aaggtCAGTGTTtttttgt
0 UAACACUG m7b Created no TS -0.155000 -0.240000
hsa-miR-548a-3p aaggtCAGTTTTtttttgt
0 CAAAACUG m7b Disrupted -0.133000 no TS 3.240000
hsa-miR-548ae aaggtcAGTTTTTttttgt
5
CAAAAACU m7b Disrupted 0.009000 0.055000 1.370000
hsa-miR-548ah-3p aaggtcAGTTTTTttttgt
5
CAAAAACU m7b Disrupted 0.009000 0.055000 0.700000
hsa-miR-548aj-3p aaggtcAGTTTTTttttgt
5
UAAAAACU m7b Disrupted 0.009000 0.055000 1.360000
hsa-miR-548am-3p aaggtcAGTTTTTttttgt
5
CAAAAACU m7b Disrupted 0.009000 0.055000 1.280000
hsa-miR-548aq-3p aaggtcAGTTTTTttttgt
5
CAAAAACU m7b Disrupted 0.009000 0.055000 1.250000
hsa-miR-548ar-3p aaggtCAGTTTTtttttgt
0 UAAAACUG m7b Disrupted -0.087000 no TS 0.070000
hsa-miR-548e aaggtCAGTTTTTttttgt
0 AAAAACUG m8a Disrupted -0.124000 no TS 0.670000
hsa-miR-548f aaggtCAGTTTTTttttgt
0 AAAAACUG m8a Disrupted -0.133000 no TS 0.080000
hsa-miR-548x-3p aaggtcAGTTTTTttttgt
5
UAAAAACU m7b Disrupted 0.009000 0.055000 1.360000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.411331A>T COSN6320646 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3120-3p gataatgctTTGCTGTcgt
2
CACAGCAA m7b (m6c->m7b) 0.215000 0.068000 -0.010000
hsa-miR-330-3p gataaTGCTTTGCtgtcgt
2
GCAAAGCA m8a Created -0.021000 -0.210000 -0.370000
hsa-miR-4422 gataATGCTTTgctgtcgt
6
AAAAGCAU m7b Created 0.077000 -0.029000 -0.140000
hsa-miR-545-3p gataatgcTTTGCTGtcgt
6
UCAGCAAA m7b Created -0.064000 -0.201000 -0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
407662 rs189617307 G
A hsa-miR-10a-5p
hsa-miR-10b-5p
hsa-miR-3713
hsa-miR-4725-5p
hsa-miR-504-5p
1
1
0
1
1
ggatACAGGGTct
ggatACAGGGTct
GGATACAgggtct
ggataCAGGGTCt
ggataCAGGGTCt
Created
Created
Created
Created
Created
N
N
N
N
N
-0.256
-0.256
-0.147
-0.284
-0.284
408816 rs116527520 G G hsa-miR-584-3p
1
gactacGGAACTG
Disrupted
N
0.018
A hsa-miR-148b-5p
hsa-miR-20b-3p
hsa-miR-3137
hsa-miR-3686
hsa-miR-4277
hsa-miR-6874-3p
1
1
1
1
1
1
gactaCAGAACTg
gACTACAGAactg
gaCTACAGAactg
gacTACAGAActg
gactacAGAACTG
gactaCAGAACTg
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
0.031
0.035
0.033
0.075
0.041
0.031
409189 rs15640 G G hsa-miR-3929
hsa-miR-4419b
hsa-miR-4478
hsa-miR-4484
hsa-miR-4539
hsa-miR-548an
hsa-miR-6768-3p
2
2
2
4
2
4
4
agtTCAGCCTtta
agtTCAGCCTtta
agtTCAGCCTtta
agttcaGCCTTTA
AGTTCAGccttta
agttcaGCCTTTA
agttcaGCCTTTA
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
-0.059
-0.05
-0.031
0.02
0.072
0.062
0.045
409828 rs35957122 - CTT hsa-miR-3653
hsa-miR-4524b-3p
6
1
caccctgtCTTCTTAAt
cacCCTGTCTtcttaat
Unknown
Unknown
N
N
0.179
0.016
- hsa-miR-208a-3p
hsa-miR-208b-3p
hsa-miR-3617-5p
hsa-miR-499a-5p
hsa-miR-641
6
6
6
6
6
caccctGTCTTAAt
caccctGTCTTAAt
cacccTGTCTTAat
caccctGTCTTAAt
cacccTGTCTTAat
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
0.088
0.088
0.1
0.09
0.103
410417 rs1050979 A A hsa-miR-20b-3p
hsa-miR-3137
hsa-miR-3686
hsa-miR-4652-3p
hsa-miR-4743-3p
1
1
1
1
1
CTACAGAaaaccc
CTACAGAaaaccc
cTACAGAAaaccc
ctACAGAAAaccc
ctACAGAAAaccc
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
0.002
-0.004
0.047
0.086
0.078
G hsa-miR-3074-5p
hsa-miR-486-5p
hsa-miR-7152-5p
2
1
1
ctaCAGGAAAccc
cTACAGGAaaccc
ctACAGGAAAccc
Created
Created
Created
N
N
N
0.039
-0.018
-0.002
410513 rs1877176 A A hsa-miR-1183
hsa-miR-200b-3p
hsa-miR-200c-3p
hsa-miR-429
1
1
1
1
TACAGTAttgtta
taCAGTATTgtta
taCAGTATTgtta
taCAGTATTgtta
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
0.012
0.015
0.006
0.015
G hsa-miR-141-3p
hsa-miR-200a-3p
1
1
taCAGTGTTgtta
taCAGTGTTgtta
Created
Created
N
N
-0.025
-0.025
410997 rs201128980 G T hsa-miR-548a-3p
hsa-miR-548ae
hsa-miR-548ah-3p
hsa-miR-548aj-3p
hsa-miR-548am-3p
hsa-miR-548aq-3p
hsa-miR-548ar-3p
hsa-miR-548az-3p
hsa-miR-548e-3p
hsa-miR-548f-3p
hsa-miR-548j-3p
hsa-miR-548x-3p
0 ggtCAGTTTTttt
ggtcAGTTTTTtt
ggtcAGTTTTTtt
ggtcAGTTTTTtt
ggtcAGTTTTTtt
ggtcAGTTTTTtt
ggtCAGTTTTttt
ggtCAGTTTTttt
ggtCAGTTTTttt
ggtCAGTTTTttt
ggtcAGTTTTTtt
ggtcAGTTTTTtt
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
N
N
-0.133
-0.046
-0.046
-0.046
-0.046
-0.046
-0.087
-0.105
-0.124
-0.133
-0.046
-0.046
G hsa-miR-548ac
hsa-miR-548d-3p
hsa-miR-548h-3p
hsa-miR-548z
0 ggtcaGGTTTTTt
ggtcaGGTTTTTt
ggtcaGGTTTTTt
ggtcaGGTTTTTt
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
-0.105
-0.077
-0.114
-0.114
410997 rs3842113 - T hsa-miR-548a-3p
hsa-miR-548ae
hsa-miR-548ah-3p
hsa-miR-548aj-3p
hsa-miR-548am-3p
hsa-miR-548aq-3p
hsa-miR-548ar-3p
hsa-miR-548az-3p
hsa-miR-548e-3p
hsa-miR-548f-3p
hsa-miR-548j-3p
hsa-miR-548x-3p
0 ggtCAGTTTTttt
ggtcAGTTTTTtt
ggtcAGTTTTTtt
ggtcAGTTTTTtt
ggtcAGTTTTTtt
ggtcAGTTTTTtt
ggtCAGTTTTttt
ggtCAGTTTTttt
ggtCAGTTTTttt
ggtCAGTTTTttt
ggtcAGTTTTTtt
ggtcAGTTTTTtt
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
N
N
N
N
N
N
-0.002
-0.006
-0.006
-0.006
-0.006
-0.006
-0.002
-0.002
-0.002
-0.002
-0.006
-0.006
-
411201 rs1050985 C C hsa-miR-214-3p
hsa-miR-3619-5p
hsa-miR-4291
hsa-miR-761
hsa-miR-922
2
2
2
4
4
cactttCTGCTGA
cactttCTGCTGA
cactttCTGCTGA
cactttCTGCTGA
cacttTCTGCTGA
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
-0.094
-0.104
-0.226
-0.094
-0.306
T hsa-miR-545-3p
hsa-miR-548az-5p
hsa-miR-548p
hsa-miR-548t-5p
2
2
2
2
cacttTTTGCTGA
CACTTTTtgctga
cactTTTTGCTga
CACTTTTtgctga
Created
Created
Created
Created
N
N
N
N
-0.195
0.046
-0.036
0.046

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