SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001042536
Gene Symbol:	INSC
Description:	Homo sapiens inscuteable homolog (Drosophila) (INSC), transcript variant 1, mRNA.
Gene Location:	chr11(+):15136483-15268754
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.15246373A>G			COSN14637885		PCSI_0072_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-148a-5p	cattttttAGAACTTTgga	0	AAAGUUCU	m8a	Created	no TS	-0.102000	-0.060000
hsa-miR-3168	catttttTAGAACTttgga	0	GAGUUCUA	m7b	Created	no TS	-0.159000	-3.340000
hsa-miR-4799-5p	catttTTTAGAactttgga	0	AUCUAAAU	m6b	Created	no TS	0.008000	-5.270000
hsa-miR-561-3p	cattttttaAAACTTTGga	3	CAAAGUUU	m8a	(m8a->m7b)	-0.004000	0.019000	0.200000
hsa-miR-148a-5p	cattttttAGAACTTTgga	0	AAAGUUCU	m8a	Created	no TS	-0.102000	-0.060000
hsa-miR-3168	catttttTAGAACTttgga	0	GAGUUCUA	m7b	Created	no TS	-0.159000	-3.340000
hsa-miR-4799-5p	catttTTTAGAactttgga	0	AUCUAAAU	m6b	Created	no TS	0.008000	-5.270000
hsa-miR-561-3p	cattttttaAAACTTTGga	3	CAAAGUUU	m8a	(m8a->m7b)	-0.004000	0.019000	0.200000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.15246751T>A			COSN8941352		SS6003314		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-371a-5p	ttgctTTTGAGTaacctcc	0	ACUCAAAC	m7a	Created	NA	NA	-0.190000
hsa-miR-371b-5p	ttgcTTTTGAGTaacctcc	0	ACUCAAAA	m8a	Created	no TS	0.023000	-0.420000
hsa-miR-373-5p	ttgcTTTTGAGTaacctcc	0	ACUCAAAA	m8a	Created	no TS	0.023000	-0.550000
hsa-miR-466	ttgctttTGTGTAacctcc	2	AUACACAU	m6b	Disrupted	-0.169000	-0.140000	0.040000
hsa-miR-4731-3p	ttgcttTTGTGTaacctcc	2	CACACAAG	m6b	Disrupted	-0.146000	-0.130000	0.163000
hsa-miR-4801	ttgcttTTGTGTAacctcc	2	UACACAAG	m7a	Disrupted	-0.149000	-0.130000	0.010000
hsa-miR-616-5p	ttgcTTTTGAGTaacctcc	0	ACUCAAAA	m8a	Created	no TS	0.014000	-0.430000
hsa-miR-888-5p	ttgctTTTGAGTAacctcc	0	UACUCAAA	m8a	Created	no TS	-0.124000	-1.722000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.15246816C>G			13_53		SJMB008_D		Medulloblastoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-766-5p	gattgaTTCCTCCTcaaaa	0	AGGAGGAA	m8a	Disrupted	-0.176	no TS	5.47

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
15246755	rs72860410	A	A	hsa-miR-3941 hsa-miR-466 hsa-miR-4672 hsa-miR-655-5p	4 4 4 3	TGTGTAAcctcct TGTGTAAcctcct TGTGTAAcctcct tgtgTAACCTCct	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.016 -0.029 -0.021 -0.055
			G	hsa-miR-3975 hsa-miR-4695-5p	3 2	tgtgTAGCCTCct tgtgtaGCCTCCT	Created Created	N N	-0.131 -0.211
15247159	rs59080356	T	T	hsa-miR-3941 hsa-miR-466 hsa-miR-4672 hsa-miR-4731-3p hsa-miR-4801	2 2 2 2 2	atTGTGTAAaatc atTGTGTAAaatc atTGTGTAAaatc aTTGTGTAaaatc aTTGTGTAaaatc	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.141 -0.14 -0.136 -0.13 -0.13
			C	hsa-miR-3680-3p hsa-miR-450b-5p hsa-miR-507 hsa-miR-557	2 2 2 2	attgTGCAAAAtc attgTGCAAAAtc attGTGCAAAAtc attGTGCAAAAtc	Created Created Created Created	N N N N	-0.123 -0.129 -0.414 -0.403

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