SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001563
Gene Symbol:	IMPG1
Description:	Homo sapiens interphotoreceptor matrix proteoglycan 1 (IMPG1), mRNA.
Gene Location:	chr6(-):76631061-76782335
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.75921803C>A			COSN8781264		SS6003109		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3190-3p	ccaggtttgCTTCCACctt	1	UGUGGAAG	m7b	(m7b->m6b)	-0.157000	no TS	2.180000
hsa-miR-671-5p	ccaggtttGCTTCCacctt	5	AGGAAGCC	m6b	Disrupted	-0.130000	no TS	13.280000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.75921871A>G			COSN15280374		SM-4B295		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3170	aaAACCCCAGatgcaatca	2	CUGGGGUU	m8a	(m7b->m8a)	-0.458000	-0.267000	0.460000
hsa-miR-33a-5p	aaaaccccaAATGCAatca	3	GUGCAUUG	m6b	Disrupted	-0.068000	no TS	6.620000
hsa-miR-33b-5p	aaaaccccaAATGCAatca	3	GUGCAUUG	m6b	Disrupted	-0.068000	no TS	1.890000
hsa-miR-4260	aaaaCCCCAAatgcaatca	2	CUUGGGGC	m6b	Disrupted	-0.180000	no TS	4.370000
hsa-miR-450a-3p	aaaaCCCCAAatgcaatca	2	AUUGGGGA	m6b	Disrupted	-0.184000	no TS	5.350000
hsa-miR-4667-5p	aaaaCCCCAGatgcaatca	0	ACUGGGGA	m6b	Created	no TS	-0.203000	-0.250000
hsa-miR-5572	aaaACCCCAAatgcaatca	2	GUUGGGGU	m7b	(m7b->m6c)	-0.420000	no TS	0.770000
hsa-miR-637	aaaaCCCCAGatgcaatca	0	ACUGGGGG	m6b	Created	no TS	-0.201000	-14.090000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
75921800	rs144253965	C	C	hsa-miR-3190-3p hsa-miR-6079 hsa-miR-671-5p hsa-miR-6828-5p	1 5 5 4	ttgCTTCCACctt ttGCTTCCAcctt ttGCTTCCAcctt tTGCTTCCAcctt	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.157 -0.207 -0.13 -0.349
75921801	rs73751760	T	T	hsa-miR-3190-3p hsa-miR-6079 hsa-miR-671-5p hsa-miR-6828-5p	1 5 5 4	tttgCTTCCACct tttGCTTCCAcct tttGCTTCCAcct ttTGCTTCCAcct	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.157 -0.207 -0.13 -0.349
			C	hsa-miR-1233-5p hsa-miR-4300 hsa-miR-5591-5p hsa-miR-6090 hsa-miR-6726-5p hsa-miR-6778-5p hsa-miR-6827-5p hsa-miR-920	1 5 5 5 5 1 5 5	tttgCTCCCACct tttGCTCCCAcct tttGCTCCCAcct tttGCTCCCAcct tttGCTCCCAcct tttgCTCCCACct tttGCTCCCAcct tttGCTCCCAcct	Created Created Created Created Created Created Created Created	N N N N N N N N	-0.209 -0.185 -0.185 -0.199 -0.189 -0.19 -0.18 -0.182
75921876	rs146172533	-	AAAC	hsa-miR-193b-5p hsa-miR-3170 hsa-miR-4260 hsa-miR-450a-2-3p hsa-miR-5572 hsa-miR-6737-5p hsa-miR-6812-5p hsa-miR-6819-5p hsa-miR-6855-5p	2 2 2 2 2 2 2 2 2	ttattaAAACCCCAaatgc ttattaaAACCCCAAatgc ttattaaaaCCCCAAAtgc ttattaaaaCCCCAAAtgc ttattaaaACCCCAAAtgc ttattaaaACCCCAAatgc ttattaaaACCCCAAatgc ttattaaaACCCCAAatgc ttattaaAACCCCAAatgc	Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N N N	-0.426 -0.458 -0.18 -0.184 -0.42 -0.201 -0.201 -0.208 -0.447
			-	hsa-miR-1225-5p hsa-miR-1229-5p hsa-miR-555	3 3 4	ttatTACCCAAatgc ttatTACCCAAatgc ttaTTACCCAaatgc	Unknown Unknown Unknown	N N N	-0.206 -0.187 -0.173
75921876	rs201822623	C	C	hsa-miR-193b-5p hsa-miR-3170 hsa-miR-4260 hsa-miR-450a-2-3p hsa-miR-5572 hsa-miR-6737-5p hsa-miR-6812-5p hsa-miR-6819-5p hsa-miR-6855-5p	2 2 2 2 2 2 2 2 2	ttaAAACCCCAaa ttaaAACCCCAAa ttaaaaCCCCAAA ttaaaaCCCCAAA ttaaaACCCCAAA ttaaaACCCCAAa ttaaaACCCCAAa ttaaaACCCCAAa ttaaAACCCCAAa	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N	-0.426 -0.458 -0.18 -0.184 -0.42 -0.201 -0.201 -0.208 -0.447
			A	hsa-miR-3940-5p hsa-miR-4507 hsa-miR-629-5p hsa-miR-6839-3p	2 2 2 2	ttaaaAACCCAAa ttaaaAACCCAAa ttaaAAACCCAaa ttaaAAACCCAAa	Created Created Created Created	N N N N	-0.162 -0.162 -0.152 -0.387

Genome Browser