SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_002182
Gene Symbol: IL1RAP
Description: Homo sapiens interleukin 1 receptor accessory protein (IL1RAP), transcript variant 3, mRNA.
Gene Location: chr3(+):190231839-190369308
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Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr3:g.190648997A>G COSN7841798 8067226 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3613-3p cctgTTTTTGTatgtctcc
0 ACAAAAAA m7a Created NA NA -0.060000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.190649207A>G COSN7758275 ASHPC_0008_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7f-2-3p ggCTGTATAGtacataacc
1
CUAUACAG m8a (m7a->m8a) -0.092000 -0.012000 0.310000
hsa-miR-1284 ggcTGTATAGtacataacc
0 UCUAUACA m7b (m6b->m7b) no TS -0.055000 -0.010000
hsa-miR-3924 ggctgtataATACATAacc
0 AUAUGUAU m7b (m7b->m6c) -0.062000 0.032000 No effect
hsa-miR-625-3p ggctgTATAGTacataacc
0 GACUAUAG m6b Created no TS -0.008000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.190649708G>T COSN1937977 RK061_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1197 gtcttaGTGTCCTtgagag
0 UAGGACAC m7b Created no TS -0.115000 -0.330000
hsa-miR-3117-5p gtctTAGTGTCcttgagag
0 AGACACUA m7b Created no TS -0.048000 No effect
hsa-miR-3922-5p gtcttagtGGCCTTGAgag
0 UCAAGGCC m8a Disrupted -0.191000 no TS 4.790000
hsa-miR-4717-5p gtcttaGTGGCCTtgagag
1
UAGGCCAC m7b Disrupted -0.161000 no TS 0.020000
hsa-miR-4753-5p gtcttagTGGCCTTGagag
1
CAAGGCCA m8a Disrupted -0.102000 no TS -2.380000
hsa-miR-561-5p gtcttagtgTCCTTGAgag
0 AUCAAGGA m7b (m6c->m7b) no TS -0.025000 -3.760000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
190649938 rs114523823 - A hsa-miR-190a-3p
hsa-miR-3924
hsa-miR-5011-5p
hsa-miR-568
4
1
4
1
ttatacATATATA
ttATACATAtata
ttatacATATATA
TTATACAtatata
Unknown
Unknown
Unknown
Unknown
N
N
N
N
0.077
-0.022
0.066
-0.027

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