SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_172217
Gene Symbol:	IL16
Description:	Homo sapiens interleukin 16 (IL16), transcript variant 3, mRNA.
Gene Location:	chr15(+):81517639-81605104
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.81308953C>T			COSN14614081		8012352		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4642	cttctagGATGCCAcccag	2	AUGGCAUC	m7b	Created	-0.023000	-0.166000	-0.770000
hsa-miR-4642	cttctagGATGCCAcccag	2	AUGGCAUC	m7b	Created	-0.023000	-0.166000	-0.770000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.81310385C>T			COSN1685775		RK046_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4773	ttcagctcaCTGTTCTatt	2	CAGAACAG	m7b	(m7b->m6c)	0.073000	0.084000	0.020000
hsa-miR-556-5p	ttcAGCTCATtgttctatt	2	GAUGAGCU	m7b	(m6b->m7b)	-0.110000	-0.063000	No effect
hsa-miR-4773	ttcagctcaCTGTTCTatt	2	CAGAACAG	m7b	(m7b->m6c)	0.073000	0.084000	0.020000
hsa-miR-556-5p	ttcAGCTCATtgttctatt	2	GAUGAGCU	m7b	(m6b->m7b)	-0.110000	-0.063000	No effect
hsa-miR-4773	ttcagctcaCTGTTCTatt	0	CAGAACAG	m7b	(m7b->m6c)	0.073	0.084	0.02
hsa-miR-556-5p	ttcAGCTCATtgttctatt	0	GAUGAGCU	m7b	(m6b->m7b)	-0.11	-0.063	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.81311655G>A			COSN8479490		AOCS-095-3-1		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-18a-3p	gctcagagAGGGCAGgcat	0	ACUGCCCU	m7b	Disrupted	-0.602000	-0.532000	4.890000
hsa-miR-3183	gctcAGAGAGGgcaggcat	2	GCCUCUCU	m7b	Disrupted	-0.034000	-0.070000	0.940000
hsa-miR-4723-3p	gctcAGAGAGGGcaggcat	2	CCCUCUCU	m8a	Disrupted	-0.069000	-0.077000	2.480000
hsa-miR-5581-5p	gctcagaGAAGGCaggcat	1	AGCCUUCC	m6b	Created	-0.198000	-0.204000	-0.020000
hsa-miR-942	gctcAGAGAAGgcaggcat	0	UCUUCUCU	m7b	Created	0.043000	0.124000	-0.110000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
81309551	rs187715544	G	G	hsa-miR-1238-3p hsa-miR-3183 hsa-miR-4723-3p hsa-miR-670-3p hsa-miR-6769b-3p hsa-miR-6780a-3p hsa-miR-6881-3p hsa-miR-7111-3p	3 2 2 3 2 3 3 2	gggaGAGGAAAta ggGAGAGGAaata ggGAGAGGAaata gggaGAGGAAAta ggGAGAGGAaata gggAGAGGAAata gggAGAGGAAata ggGAGAGGAAata	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N	-0.032 -0.07 -0.077 -0.017 -0.091 -0.049 -0.055 -0.19
			A	hsa-miR-4659a-3p hsa-miR-4659b-3p hsa-miR-4713-5p hsa-miR-629-3p hsa-miR-6867-3p hsa-miR-6875-3p hsa-miR-942-5p	3 3 2 2 2 3 2	gggAGAAGAAAta gggAGAAGAAAta GGGAGAAgaaata GGGAGAAgaaata GGGAGAAgaaata gggaGAAGAAAta ggGAGAAGAaata	Created Created Created Created Created Created Created	N N N N N N N	0.042 0.031 -0.12 -0.117 -0.12 0.042 -0.019
81312399	rs17875568	A	A	hsa-miR-3120-5p hsa-miR-6740-3p hsa-miR-6888-3p	2 2 2	tggaAGACAGAga tgGAAGACAgaga tggaAGACAGAga	Disrupted Disrupted Disrupted	N N N	-0.016 -0.03 -0.03
			G	hsa-miR-4297 hsa-miR-5001-3p hsa-miR-5581-5p hsa-miR-6728-3p	2 2 2 1	tGGAAGGCAgaga tggaAGGCAGAga tGGAAGGCAgaga tggaagGCAGAGA	Created Created Created Created	N N N N	-0.295 -0.135 -0.274 -0.065

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