SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_002188
Gene Symbol:	IL13
Description:	Homo sapiens interleukin 13 (IL13), mRNA.
Gene Location:	chr5(+):131993864-131996801
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.132660308G>A			COSN2070568		RK092_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-450b-5p	ttatTTGCAAAgacaggac	0	UUUUGCAA	m7b	Created	no TS	-0.134000	-0.070000
hsa-miR-4772-3p	ttatTTGCAGagacaggac	5	CCUGCAAC	m6b	Disrupted	-0.547000	-0.425000	0.030000
hsa-miR-511	ttatttgcAAAGACAggac	0	GUGUCUUU	m7b	Created	no TS	-0.059000	-0.120000
hsa-miR-518a-5p	ttaTTTGCAGagacaggac	0	CUGCAAAG	m7a	(m7a->m6a)	no TS	-0.092000	-0.120000
hsa-miR-527	ttaTTTGCAGagacaggac	0	CUGCAAAG	m7a	(m7a->m6a)	no TS	-0.092000	-0.120000
hsa-miR-593-3p	ttatttgCAGAGACAggac	3	UGUCUCUG	m8a	Disrupted	-0.436000	-0.119000	5.510000
hsa-miR-450b-5p	ttatTTGCAAAgacaggac	0	UUUUGCAA	m7b	Created	no TS	-0.134	-0.07
hsa-miR-4772-3p	ttatTTGCAGagacaggac	3	CCUGCAAC	m6b	Disrupted	-0.547	-0.425	0.03
hsa-miR-511	ttatttgcAAAGACAggac	0	GUGUCUUU	m7b	Created	no TS	-0.059	-0.12
hsa-miR-518a-5p	ttaTTTGCAGagacaggac	0	CUGCAAAG	m7a	(m7a->m6a)	no TS	-0.092	-0.12
hsa-miR-527	ttaTTTGCAGagacaggac	0	CUGCAAAG	m7a	(m7a->m6a)	no TS	-0.092	-0.12
hsa-miR-593-3p	ttatttgCAGAGACAggac	3	UGUCUCUG	m8a	Disrupted	-0.436	-0.119	5.51

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.132660351C>G			COSN9925887		C0069T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2115-3p	tttttctTTCTGATGtcaa	1	CAUCAGAA	m8a	Disrupted	-0.159000	no TS	0.720000
hsa-miR-499a-3p	tttttctttGTGATGTcaa	0	AACAUCAC	m7b	(m6c->m7b)	no TS	-0.241000	-4.030000
hsa-miR-499b-3p	tttttctttGTGATGTcaa	0	AACAUCAC	m7b	(m6c->m7b)	no TS	-0.241000	1.140000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
132660333	rs75868517	G	G	hsa-miR-2276-3p hsa-miR-4772-3p hsa-miR-891b	6 5 5	gaagTTGCAGAtt gaaGTTGCAGAtt gAAGTTGCAgatt	Disrupted Disrupted Disrupted	N N N	-0.147 -0.421 -0.381
			A	hsa-miR-3607-3p hsa-miR-3686	6 6	gaagTTACAGAtt gaagTTACAGAtt	Created Created	N N	-0.097 -0.17
132660337	rs201863406	A	A	hsa-miR-2276-3p hsa-miR-4772-3p	6 6	TTGCAGAttcatt TTGCAGAttcatt	Disrupted Disrupted	N N	-0.15 -0.185
132660779	rs200557616	C	C	hsa-miR-125a-5p hsa-miR-125b-5p hsa-miR-4319 hsa-miR-593-3p hsa-miR-627-5p hsa-miR-924	2 2 2 3 2 2	cagagaCTCAGGG cagagaCTCAGGG cagagaCTCAGGG CAGAGACtcaggg cagAGACTCAggg cagAGACTCAggg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.148 -0.157 -0.129 -0.119 -0.066 -0.067
			T	hsa-miR-216b-5p hsa-miR-3140-5p hsa-miR-345-3p hsa-miR-5187-3p	3 2 2 2	cAGAGATTcaggg cagagATTCAGGg cagagaTTCAGGG cagaGATTCAGgg	Created Created Created Created	N N N N	0.013 -0.017 -0.089 -0.038

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