SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000572
Gene Symbol:	IL10
Description:	Homo sapiens interleukin 10 (IL10), mRNA.
Gene Location:	chr1(-):206940947-206945839
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.206767982T>C			ICGC_BE566914-2A78-11E2-BDED-1EFD496BB9B8		CPCG_0103_Pr_P_P4		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.206768521C>A			COSN15339269		SNU_WGS_02_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-369-3p	tgtacctcTATTATagaat	10	AAUAAUAC	m6b	Created	-0.003000	0.009000	-0.300000
hsa-miR-374a-5p	tgtacctcTATTATAgaat	3	UUAUAAUA	m7b	Created	-0.109000	-0.144000	-2.700000
hsa-miR-374b-5p	tgtacctcTATTATAgaat	3	AUAUAAUA	m7b	Created	-0.120000	-0.136000	-0.180000
hsa-miR-5692b	tgtacctcTATTATagaat	8	AAUAAUAU	m6b	Created	-0.058000	-0.046000	-4.430000
hsa-miR-5692c	tgtacctcTATTATagaat	8	AAUAAUAU	m6b	Created	-0.079000	-0.067000	-4.610000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.206768542G>C			COSN8637376		J90_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3179	cagCCCCTTCagaaacctt	0	AGAAGGGG	m7b	(m6c->m7b)	no TS	-0.339000	-0.010000
hsa-miR-4762-3p	cagcccctTCAGAAacctt	0	CUUCUGAU	m6b	Created	no TS	-0.019000	1.760000
hsa-miR-513c-5p	cagcccCTTGAGAAacctt	1	UUCUCAAG	m8a	Disrupted	-0.228000	no TS	4.740000
hsa-miR-514b-5p	cagcccCTTGAGAAacctt	1	UUCUCAAG	m8a	Disrupted	-0.207000	no TS	0.030000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
206768291	rs3024510	A	A	hsa-miR-1267 hsa-miR-3182 hsa-miR-367-5p hsa-miR-4652-3p hsa-miR-8057	2 2 2 2 8	gagcCAACAGAag gagccaACAGAAG gagcCAACAGAag gagccAACAGAAg GAGCCAAcagaag	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.058 -0.062 -0.058 0.015 -0.135
			T	hsa-miR-3192-3p hsa-miR-4502 hsa-miR-4762-3p	2 2 2	gagccATCAGAAg gagcCATCAGAag gagccATCAGAAg	Created Created Created	N N N	-0.026 -0.058 0.061

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