SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001111283
Gene Symbol: IGF1
Description: Homo sapiens insulin-like growth factor 1 (somatomedin C) (IGF1), transcript variant 4, mRNA.
Gene Location: chr12(-):102789644-102874378
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr12:g.102396577A>G COSN10096273 C0035T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-155-3p taaaGTAGGAaaaataaaa
 0 CUCCUACA m6b Disrupted -0.479000 -0.355000 0.020000
hsa-miR-3162-3p taaaGTAGGGAaaataaaa
 0 UCCCUACC m7a Created -0.063000 -0.226000 No effect
hsa-miR-3685 taaaGTAGGAAAaataaaa
 0 UUUCCUAC m8a Disrupted -0.430000 -0.186000 0.010000
hsa-miR-384 taaagTAGGAAaaataaaa
 0 AUUCCUAG m6b Disrupted -0.052000 0.007000 No effect
hsa-miR-4446-5p taaagtAGGGAAAataaaa
 3
 AUUUCCCU m7b Created 0.002000 -0.188000 No effect
hsa-miR-4755-5p taaagtAGGGAAAataaaa
 0 UUUCCCUU m7a Created no TS -0.063000 No effect
hsa-miR-5006-3p taaagtAGGGAAAataaaa
 0 UUUCCCUU m7a Created no TS -0.076000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.102396804A>T COSN8691912 AOCS-056-1-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-302b-5p cttttTTAAAGTaaaaaaa
 0 ACUUUAAC m7a Disrupted 0.134000 0.134000 0.020000
hsa-miR-302d-5p cttttTTAAAGTaaaaaaa
 0 ACUUUAAC m7a Disrupted 0.138000 0.138000 0.010000
hsa-miR-323a-3p ctttttTAATGTaaaaaaa
 2
 CACAUUAC m6b Created 0.082000 0.096000 -0.060000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.102397170G>T COSN8691913 AOCS-108-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-508-5p cccaggCTGGAGTgcagtg
 2
 UACUCCAG m7b Disrupted -0.032000 -0.138000 No effect
hsa-miR-766-3p cccagGCTGGAGTgcagtg
 2
 ACUCCAGC m8a Disrupted -0.119000 -0.158000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.102397714A>G COSN4726349 tumor_4102009 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1915-5p cccttGCAAGGaccataaa
 6
 ACCUUGCC m6b Created -0.032000 -0.014000 No effect
hsa-miR-450b-5p cccTTGCAAAgaccataaa
 0 UUUUGCAA m7b (m7b->m6c) 0.301000 0.110000 No effect
hsa-miR-502-5p cccttGCAAGGAccataaa
 6
 AUCCUUGC m7b Created -0.100000 -0.113000 -0.220000


Mutation Mutation ID Sample Name Cancer Type
chr12:g.102398103G>T COSN8585171 J9_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr12:g.102398336A>T COSN15429276 AOCS-150-8-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4450 ttctgccaAATCCCCcttg
 2
 UGGGGAUU m7b Disrupted -0.127000 -0.059000 2.280000
hsa-miR-4525 ttctgccaaATCCCCCttg
 2
 GGGGGGAU m7b (m7b->m6b) -0.501000 -0.415000 0.030000
hsa-miR-5010-5p ttctgccaaATCCCCCTtg
 2
 AGGGGGAU m8a (m8a->m7a) -0.537000 -0.413000 -1.160000
hsa-miR-625-5p ttctgccaaTTCCCCCTtg
 2
 AGGGGGAA m8a (m7a->m8a) -0.545000 -0.617000 0.030000
hsa-miR-4450 ttctgccaAATCCCCcttg
 2
 UGGGGAUU m7b Disrupted -0.127000 -0.059000 2.280000
hsa-miR-4525 ttctgccaaATCCCCCttg
 2
 GGGGGGAU m7b (m7b->m6b) -0.501000 -0.415000 0.030000
hsa-miR-5010-5p ttctgccaaATCCCCCTtg
 2
 AGGGGGAU m8a (m8a->m7a) -0.537000 -0.413000 -1.160000
hsa-miR-625-5p ttctgccaaTTCCCCCTtg
 2
 AGGGGGAA m8a (m7a->m8a) -0.545000 -0.617000 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.102399806T>G COSN4726350 tumor_4116738 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-298 taggcagtCTTCTGCagac
 10
 AGCAGAAG m7b Disrupted 0.085000 0.039000 No effect
hsa-miR-3166 taggcagtcGTCTGCagac
 0 CGCAGACA m6b Created no TS -0.028000 -3.870000
hsa-miR-4771 taggcagtcGTCTGCagac
 0 AGCAGACU m6b Created no TS -0.034000 -0.400000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.102400585C>G COSN10096274 C0057T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-545-5p aacTTTACTGttattctta
 1
 UCAGUAAA m7b (m6c->m7b) -0.102000 -0.075000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.102401314G>A COSN8959782 SS6003317 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-587 ctcATGGAAAaaatgaaca
 4
 UUUCCAUA m7a (m6b->m7a) 0.076000 0.110000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.102401339G>A COSN1140934 HCC29T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1288 attttaGCAGTCCtggttt
 0 UGGACUGC m7b Disrupted -0.202000 -0.034000 0.010000
hsa-miR-3169 attttagCAGTCCTggttt
 3
 UAGGACUG m7b Disrupted -0.047000 no TS 0.340000
hsa-miR-1288 attttaGCAGTCCtggttt
 0 UGGACUGC m7b Disrupted -0.202 -0.034 0.01
hsa-miR-3169 attttagCAGTCCTggttt
 0 UAGGACUG m7b Disrupted -0.047 no TS 0.34

Mutation Mutation ID Sample Name Cancer Type
chr12:g.102401779A>T COSN8585172 J52_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3924 tatgttttATACATAgaaa
 7
 AUAUGUAU m7b Created 0.136000 0.079000 No effect
hsa-miR-4307 tatgttttAAACATagaaa
 0 AAUGUUUU m6b Disrupted 0.296000 0.246000 No effect
hsa-miR-568 tatgttTTATACATagaaa
 0 AUGUAUAA m8a Created -0.005000 -0.087000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.102401988G>A COSN1140935 HX13T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-10a-3p atatttgcCGAATTTGgcc
 0 CAAAUUCG m8a Disrupted 0.235000 0.191000 0.100000
hsa-miR-1271-5p atattTGCCAAatttggcc
 2
 CUUGGCAC m6b Created 0.019000 -0.088000 -0.010000
hsa-miR-182-5p atatTTGCCAAAtttggcc
 2
 UUUGGCAA m8a Created 0.027000 -0.219000 0.280000
hsa-miR-4470 ataTTTGCCAaatttggcc
 0 UGGCAAAC m7a (m6b->m7a) no TS -0.092000 0.530000
hsa-miR-10a-3p atatttgcCGAATTTGgcc
 0 CAAAUUCG m8a Disrupted 0.235 0.191 0.1
hsa-miR-1271-5p atattTGCCAAatttggcc
 0 CUUGGCAC m6b Created 0.019 -0.088 -0.01
hsa-miR-182-5p atatTTGCCAAAtttggcc
 0 UUUGGCAA m8a Created 0.027 -0.219 0.28
hsa-miR-4470 ataTTTGCCAaatttggcc
 0 UGGCAAAC m7a (m6b->m7a) no TS -0.092 0.53


Mutation Mutation ID Sample Name Cancer Type
chr12:g.102402255G>A COSN1140936 BN40T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr12:g.102402262T>C COSN5314334 RK169_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-20b-3p aatgttCTACAGaaaagaa
 5
 ACUGUAGU m6b Created -0.182000 -0.327000 No effect
hsa-miR-3137 aatgttCTACAGAaaagaa
 0 UCUGUAGC m7a Created no TS -0.154000 No effect
hsa-miR-3686 aatgttcTACAGAaaagaa
 7
 AUCUGUAA m6b Created -0.089000 -0.208000 No effect
hsa-miR-4482-3p aatgttctATAGAAAagaa
 10
 UUUCUAUU m7a Disrupted 0.339000 0.379000 No effect
hsa-miR-4652-3p aatgttctACAGAAaagaa
 0 GUUCUGUU m6b Created 0.027000 -0.059000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.102402397T>C COSN9032266 8051720 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-595 ttgataACACTTaaaagat
 7
 GAAGUGUG m6b Created -0.295000 -0.393000 -0.180000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
102402507 rs115707403 G G hsa-miR-155-3p
hsa-miR-3685
13
13
 gaTGTAGGAAgac
gatGTAGGAAgac
 Disrupted
Disrupted
N
N
 -0.355
-0.186
A hsa-miR-4778-3p
hsa-miR-600
hsa-miR-6740-3p
11
16
9
 gatgtAAGAAGAc
gaTGTAAGAagac
gatgtaAGAAGAC
 Created
Created
Created
N
N
N
 -0.014
-0.065
-0.168

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