SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_000618
Gene Symbol:	IGF1
Description:	Homo sapiens insulin-like growth factor 1 (somatomedin C) (IGF1), transcript variant 4, mRNA.
Gene Location:	chr12(-):102789644-102874378
Browse Associations
Browse Pathways

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102396577A>G			COSN10096273		C0035T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-155-3p	taaaGTAGGAaaaataaaa	0	CUCCUACA	m6b	Disrupted	-0.124000	no TS	0.070000
hsa-miR-3162-3p	taaaGTAGGGAaaataaaa	0	UCCCUACC	m7a	Created	-0.063000	-0.226000	No effect
hsa-miR-3685	taaaGTAGGAAAaataaaa	0	UUUCCUAC	m8a	Disrupted	-0.244000	no TS	0.330000
hsa-miR-384	taaagTAGGAAaaataaaa	0	AUUCCUAG	m6b	Disrupted	-0.057000	0.002000	No effect
hsa-miR-4446-5p	taaagtAGGGAAAataaaa	3	AUUUCCCU	m7b	Created	0.002000	-0.188000	No effect
hsa-miR-4755-5p	taaagtAGGGAAAataaaa	0	UUUCCCUU	m7a	Created	no TS	-0.063000	No effect
hsa-miR-5006-3p	taaagtAGGGAAAataaaa	0	UUUCCCUU	m7a	Created	no TS	-0.076000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102396804A>T			COSN8691912		AOCS-056-1-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-302b-5p	cttttTTAAAGTaaaaaaa	0	ACUUUAAC	m7a	Disrupted	0.134000	0.134000	0.020000
hsa-miR-302d-5p	cttttTTAAAGTaaaaaaa	0	ACUUUAAC	m7a	Disrupted	0.138000	0.138000	0.010000
hsa-miR-323a-3p	ctttttTAATGTaaaaaaa	2	CACAUUAC	m6b	Created	0.082000	0.096000	-0.060000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102397170G>T			COSN8691913		AOCS-108-1-7		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-508-5p	cccaggCTGGAGTgcagtg	2	UACUCCAG	m7b	Disrupted	-0.037000	-0.143000	No effect
hsa-miR-766-3p	cccagGCTGGAGTgcagtg	2	ACUCCAGC	m8a	Disrupted	-0.123000	-0.162000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102397714A>G			COSN4726349		tumor_4102009		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1915-5p	cccttGCAAGGaccataaa	6	ACCUUGCC	m6b	Created	-0.036000	-0.018000	No effect
hsa-miR-450b-5p	cccTTGCAAAgaccataaa	0	UUUUGCAA	m7b	(m7b->m6c)	0.289000	0.098000	No effect
hsa-miR-502-5p	cccttGCAAGGAccataaa	6	AUCCUUGC	m7b	Created	-0.108000	-0.121000	-0.220000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102398103G>T			COSN8585171		J9_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102398336A>T			COSN15429276		AOCS-150-8-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4450	ttctgccaAATCCCCcttg	2	UGGGGAUU	m7b	Disrupted	-0.127000	-0.059000	2.280000
hsa-miR-4525	ttctgccaaATCCCCCttg	2	GGGGGGAU	m7b	(m7b->m6b)	-0.505000	-0.419000	0.030000
hsa-miR-5010-5p	ttctgccaaATCCCCCTtg	2	AGGGGGAU	m8a	(m8a->m7a)	-0.541000	-0.417000	-1.160000
hsa-miR-625-5p	ttctgccaaTTCCCCCTtg	2	AGGGGGAA	m8a	(m7a->m8a)	-0.553000	-0.625000	0.030000
hsa-miR-4450	ttctgccaAATCCCCcttg	2	UGGGGAUU	m7b	Disrupted	-0.127000	-0.059000	2.280000
hsa-miR-4525	ttctgccaaATCCCCCttg	2	GGGGGGAU	m7b	(m7b->m6b)	-0.505000	-0.419000	0.030000
hsa-miR-5010-5p	ttctgccaaATCCCCCTtg	2	AGGGGGAU	m8a	(m8a->m7a)	-0.541000	-0.417000	-1.160000
hsa-miR-625-5p	ttctgccaaTTCCCCCTtg	2	AGGGGGAA	m8a	(m7a->m8a)	-0.553000	-0.625000	0.030000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102399806T>G			COSN4726350		tumor_4116738		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-298	taggcagtCTTCTGCagac	10	AGCAGAAG	m7b	Disrupted	0.085000	0.039000	No effect
hsa-miR-3166	taggcagtcGTCTGCagac	0	CGCAGACA	m6b	Created	no TS	-0.028000	-3.870000
hsa-miR-4771	taggcagtcGTCTGCagac	0	AGCAGACU	m6b	Created	no TS	-0.034000	-0.400000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102400585C>G			COSN10096274		C0057T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-545-5p	aacTTTACTGttattctta	1	UCAGUAAA	m7b	(m6c->m7b)	-0.102000	-0.075000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102401314G>A			COSN8959782		SS6003317		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-587	ctcATGGAAAaaatgaaca	4	UUUCCAUA	m7a	(m6b->m7a)	0.072000	0.102000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102401339G>A			COSN1140934		HCC29T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1288	attttaGCAGTCCtggttt	0	UGGACUGC	m7b	Disrupted	-0.207000	-0.034000	0.010000
hsa-miR-3169	attttagCAGTCCTggttt	3	UAGGACUG	m7b	Disrupted	-0.052000	no TS	0.340000
hsa-miR-1288	attttaGCAGTCCtggttt	0	UGGACUGC	m7b	Disrupted	-0.207	-0.034	0.01
hsa-miR-3169	attttagCAGTCCTggttt	0	UAGGACUG	m7b	Disrupted	-0.052	no TS	0.34

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102401779A>T			COSN8585172		J52_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3924	tatgttttATACATAgaaa	7	AUAUGUAU	m7b	Created	0.136000	0.074000	No effect
hsa-miR-4307	tatgttttAAACATagaaa	0	AAUGUUUU	m6b	Disrupted	0.293000	0.246000	No effect
hsa-miR-568	tatgttTTATACATagaaa	0	AUGUAUAA	m8a	Created	-0.010000	-0.097000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102401988G>A			COSN1140935		HX13T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-10a-3p	atatttgcCGAATTTGgcc	0	CAAAUUCG	m8a	Disrupted	0.231000	0.191000	0.100000
hsa-miR-1271-5p	atattTGCCAAatttggcc	2	CUUGGCAC	m6b	Created	0.019000	-0.092000	-0.010000
hsa-miR-182-5p	atatTTGCCAAAtttggcc	2	UUUGGCAA	m8a	Created	0.027000	-0.227000	0.280000
hsa-miR-4470	ataTTTGCCAaatttggcc	0	UGGCAAAC	m7a	(m6b->m7a)	no TS	-0.096000	0.530000
hsa-miR-10a-3p	atatttgcCGAATTTGgcc	0	CAAAUUCG	m8a	Disrupted	0.231	0.191	0.1
hsa-miR-1271-5p	atattTGCCAAatttggcc	0	CUUGGCAC	m6b	Created	0.019	-0.092	-0.01
hsa-miR-182-5p	atatTTGCCAAAtttggcc	0	UUUGGCAA	m8a	Created	0.027	-0.227	0.28
hsa-miR-4470	ataTTTGCCAaatttggcc	0	UGGCAAAC	m7a	(m6b->m7a)	no TS	-0.096	0.53

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102402255G>A			COSN1140936		BN40T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102402262T>C			COSN5314334		RK169_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-20b-3p	aatgttCTACAGaaaagaa	5	ACUGUAGU	m6b	Created	-0.003000	-0.152000	No effect
hsa-miR-3137	aatgttCTACAGAaaagaa	0	UCUGUAGC	m7a	Created	no TS	-0.158000	No effect
hsa-miR-3686	aatgttcTACAGAaaagaa	7	AUCUGUAA	m6b	Created	-0.089000	-0.212000	No effect
hsa-miR-4482-3p	aatgttctATAGAAAagaa	10	UUUCUAUU	m7a	Disrupted	0.332000	0.375000	No effect
hsa-miR-4652-3p	aatgttctACAGAAaagaa	0	GUUCUGUU	m6b	Created	0.027000	-0.062000	-0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.102402397T>C			COSN9032266		8051720		[pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-595	ttgataACACTTaaaagat	7	GAAGUGUG	m6b	Created	-0.295000	-0.396000	-0.180000

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
102396215	rs35042457	-	-	hsa-miR-3689a-5p hsa-miR-3689b-5p hsa-miR-3689e hsa-miR-3689f hsa-miR-595	12 12 12 12 9	tttTATCACActt tttTATCACActt tttTATCACActt tttTATCACActt ttttatCACACTT	Unknown Unknown Unknown Unknown Unknown	N N N N N	-0.096 -0.096 -0.096 -0.096 -0.066
102396215	rs35042457	-	G	hsa-miR-648	9	ttttatGCACACTt	Unknown	N	-0.282
102396579	rs148490103	G	G	hsa-miR-155-3p hsa-miR-3685 hsa-miR-384	21 21 21	aaaGTAGGAAaaa aaaGTAGGAAAaa aaagTAGGAAAaa	Disrupted Disrupted Disrupted	N N N	-0.124 -0.244 -0.059
102396579	rs148490103	G	T	hsa-miR-335-3p hsa-miR-485-3p hsa-miR-539-3p	21 21 21	aaagtATGAAAAA aaaGTATGAAaaa aaaGTATGAAaaa	Created Created Created	N N N	-0.001 -0.067 -0.07
102396827	rs72396631	-	-	hsa-miR-3127-3p hsa-miR-3679-3p hsa-miR-4446-5p hsa-miR-6756-3p hsa-miR-6826-3p	2 2 3 2 2	tcAAGGGGAaaaaaa tcaaGGGGAAAaaaa tcaagGGGAAAAaaa tcAAGGGGAaaaaaa tcaAGGGGAAaaaaa	Unknown Unknown Unknown Unknown Unknown	N N N N N	-0.015 -0.097 -0.036 -0.015 -0.103
102396827	rs72396631	-	GA	hsa-miR-4713-5p hsa-miR-629-3p hsa-miR-6867-3p	3 3 3	tcaagGGGAGAAaaaaa tcaagGGGAGAAAaaaa tcaagGGGAGAAaaaaa	Unknown Unknown Unknown	N N N	-0.105 -0.184 -0.115
102396828	rs3730209	G	G	hsa-miR-3127-3p hsa-miR-3679-3p hsa-miR-4446-5p hsa-miR-4780 hsa-miR-6756-3p hsa-miR-6826-3p	2 2 3 2 2 2	tcAAGGGGAaaaa tcaaGGGGAAAaa tcaagGGGAAAAa TCAAGGGgaaaaa tcAAGGGGAaaaa tcaAGGGGAAaaa	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.105 -0.097 -0.036 -0.16 -0.108 -0.103
102396828	rs3730209	G	T	hsa-miR-335-3p hsa-miR-5096	4 2	tcaaggTGAAAAA tcaaGGTGAAAAa	Created Created	N N	0.091 -0.127
102397749	rs5742709	G	G	hsa-miR-3182 hsa-miR-4652-3p hsa-miR-4659a-3p hsa-miR-4659b-3p	0	aaaACAGAAGAat aaAACAGAAgaat aaaacAGAAGAAt aaaacAGAAGAAt	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.018 0.027 0.08 0.08
102397749	rs5742709	G	C	hsa-miR-578 hsa-miR-581	4 0	aaaacACAAGAAt aaaACACAAGAat	Created Created	N N	0.054 -0.062
102397971	rs3730205	T
102397971	rs3730205	T	C	hsa-miR-20b-3p hsa-miR-4293 hsa-miR-4703-3p hsa-miR-596	12 15 12 15	aaACTACAGgcta aaactaCAGGCTA aAACTACAggcta aaactaCAGGCTA	Created Created Created Created	N N N N	-0.002 -0.042 0.043 -0.034
102398081	rs3730188	A	A	hsa-miR-142-5p hsa-miR-340-5p hsa-miR-548a-5p hsa-miR-548ab hsa-miR-548ak hsa-miR-548am-5p hsa-miR-548ap-5p hsa-miR-548aq-5p hsa-miR-548ar-5p hsa-miR-548as-5p hsa-miR-548au-5p hsa-miR-548av-5p hsa-miR-548ay-5p hsa-miR-548b-5p hsa-miR-548c-5p hsa-miR-548d-5p hsa-miR-548h-5p hsa-miR-548i hsa-miR-548j-5p hsa-miR-548k hsa-miR-548l hsa-miR-548o-5p hsa-miR-548w hsa-miR-548y hsa-miR-559 hsa-miR-5590-3p hsa-miR-568 hsa-miR-8054	11 12 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 11 12 9	tACTTTATAcagt taCTTTATAcagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt TACTTTAtacagt tACTTTATAcagt tactTTATACAgt TACTTTAtacagt	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N N N N N N N N N N N N N N N N N N	0.12 0.094 0.087 0.089 0.089 0.089 0.089 0.089 0.089 0.089 0.089 0.086 0.089 0.089 0.089 0.089 0.089 0.089 0.089 0.086 0.094 0.089 0.089 0.089 0.084 0.141 0.038 0.086
102398081	rs3730188	A	T	hsa-miR-3607-3p hsa-miR-548n	10 9	tacttTTTACAGt TACTTTTtacagt	Created Created	N N	0.038 0.086
102398359	rs57235750	C	C	hsa-miR-3665 hsa-miR-6511b-5p hsa-miR-6516-5p hsa-miR-657 hsa-miR-6811-5p	1 1 1 1 1	atttACCTGCAaa atttaCCTGCAAa atttacCTGCAAA atttACCTGCAaa atttaCCTGCAAa	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.039 -0.057 0.003 -0.067 -0.06
102398359	rs57235750	C	T	hsa-miR-450b-5p	1	atttacTTGCAAA	Created	N	0.05
102398498	rs5742707	G	G	hsa-miR-1471 hsa-miR-4446-5p	1 7	aaACGCGGGAaaa aaacgcGGGAAAA	Disrupted Disrupted	N N	-0.419 0.038
102398498	rs5742707	G	A	hsa-miR-1539 hsa-miR-3074-5p hsa-miR-3193 hsa-miR-6854-3p hsa-miR-7152-5p	1 1 1 1 1	aaaCGCAGGAaaa aaacGCAGGAAAa aaACGCAGGAaaa AAACGCAggaaaa aaacgCAGGAAAa	Created Created Created Created Created	N N N N N	-0.145 -0.026 -0.304 -0.032 0.027
102401350	rs79306998	G	G	hsa-miR-384 hsa-miR-5571-3p hsa-miR-7975	9 9 9	ggCTAGGAAtttt ggCTAGGAAtttt ggCTAGGAAtttt	Disrupted Disrupted Disrupted	N N N	0.002 -0.033 -0.039
102401350	rs79306998	G	T	hsa-miR-4661-5p	8	gGCTAGTAatttt	Created	N	-0.084
102401351	rs3730211	G	G	hsa-miR-384 hsa-miR-5571-3p hsa-miR-7975	9 9 9	aggCTAGGAAttt aggCTAGGAAttt aggCTAGGAAttt	Disrupted Disrupted Disrupted	N N N	0.002 -0.033 -0.039
102401351	rs3730211	G	T	hsa-miR-103b hsa-miR-376a-3p hsa-miR-376b-3p hsa-miR-4760-3p	6 9 9 10	aGGCTATGAattt aggCTATGAAttt aggCTATGAAttt aggctATGAATTt	Created Created Created Created	N N N N	-0.21 0.021 0.021 0.073
102401536	rs190916416	G	G	hsa-miR-6826-3p	21	acaatAGGGGAAg	Disrupted	N	-0.058
102401536	rs190916416	G	A	hsa-miR-204-5p hsa-miR-211-5p hsa-miR-4755-5p hsa-miR-5006-3p hsa-miR-5701 hsa-miR-623	21 21 21 21 2 21	acaatAAGGGAAg acaatAAGGGAAg acaatAAGGGAAg acaatAAGGGAAg ACAATAAgggaag acaatAAGGGAAg	Created Created Created Created Created Created	N N N N N N	-0.006 -0.009 -0.025 -0.006 0.074 -0.019

**Genome Browser**
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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

Genome Browser