| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_002125 |
|---|---|
| Gene Symbol: | HLA-DRB5 |
| Description: | Homo sapiens major histocompatibility complex, class II, DR beta 5 (HLA-DRB5), mRNA. |
| Gene Location: | chr6(-):32485153-32498006 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr6:g.32517389A>G | COSN14712576 | CHC322T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-212-5p |
tggctCCAAGGacaaaaaa |
0 | ACCUUGGC | m6b | Created | no TS | -0.134000 |
-6.340000 |
|
| hsa-miR-2355-3p |
tggctccaAGGACAAaaaa |
0 | AUUGUCCU | m7b | Created | no TS | -0.393000 |
-4.130000 |
|
| hsa-miR-3189-3p |
tggctCCAAGGacaaaaaa |
0 | CCCUUGGG | m6b | Created | no TS | -0.143000 |
-11.180000 |
|
| hsa-miR-432-5p |
tggCTCCAAGgacaaaaaa |
0 | UCUUGGAG | m7b | (m6c->m7b) | no TS | -0.167000 |
-15.160000 |
|
| hsa-miR-4646-3p |
tggctccaaGGACAAaaaa |
0 | AUUGUCCC | m6b | Created | no TS | -0.161000 |
-6.360000 |
|
| hsa-miR-511 |
tggctccAAAGACAaaaaa |
2 |
GUGUCUUU | m7b | Disrupted | -0.211000 | no TS |
2.550000 |
|
| hsa-miR-676-3p |
tggctccaAGGACAaaaaa |
0 | CUGUCCUA | m6b | Created | no TS | -0.156000 |
-4.030000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr6:g.32517465G>T | COSN14831949 | CHC205T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4716-3p |
acTCCCCCTTtgtgccaca |
1 |
AAGGGGGA | m8a | (m7b->m8a) | -0.248000 | -0.275000 |
-0.010000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr6:g.32517466T>C | COSN14687583 | CHC205T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4716-3p |
tacTCCCCCTgtgtgccac |
1 |
AAGGGGGA | m7b | (m7b->m6c) | -0.248000 | no TS |
8.610000 |
|
| hsa-miR-602 |
tactcccCCCGTGTgccac |
0 | GACACGGG | m7b | Created | no TS | -0.210000 |
-1.520000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr6:g.32517497C>G | COSN14713235 | CHC322T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-296-3p |
ttacctAACCCTacggcct |
1 |
GAGGGUUG | m6b | Disrupted | -0.104000 | no TS |
6.890000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr6:g.32517633C>G | COSN14702522 | CHC433T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-125a-5p |
tttCTCAGGGcctggttgc |
0 | UCCCUGAG | m7b | (m6c->m7b) | no TS | -0.206000 |
-1.440000 |
|
| hsa-miR-125b-5p |
tttCTCAGGGcctggttgc |
0 | UCCCUGAG | m7b | (m6c->m7b) | no TS | -0.225000 |
-1.440000 |
|
| hsa-miR-1291 |
tttctCAGGGCCtggttgc |
0 | UGGCCCUG | m7b | Created | no TS | -0.291000 |
-5.440000 |
|
| hsa-miR-1911-3p |
tttctcaggGCCTGGTtgc |
0 | CACCAGGC | m7b | (m6b->m7b) | no TS | -0.203000 | No effect | |
| hsa-miR-2861 |
tttctCAGGCCCtggttgc |
1 |
GGGGCCUG | m7b | Disrupted | -0.262000 | no TS | No effect | |
| hsa-miR-3918 |
tttctcaGGCCCTGgttgc |
1 |
ACAGGGCC | m7b | Disrupted | -0.264000 | no TS |
4.640000 |
|
| hsa-miR-4319 |
tttCTCAGGGcctggttgc |
0 | UCCCUGAG | m7b | (m6c->m7b) | no TS | -0.225000 |
-5.510000 |
|
| hsa-miR-4324 |
ttTCTCAGGGcctggttgc |
6 |
CCCUGAGA | m8a | (m7b->m8a) | -0.169000 | -0.169000 |
0.760000 |
|
| hsa-miR-4512 |
tttctcAGGCCCTGgttgc |
1 |
CAGGGCCU | m8a | Disrupted | -0.216000 | no TS |
1.690000 |
|
| hsa-miR-4685-5p |
tttctcagGCCCTGGttgc |
1 |
CCCAGGGC | m7b | Disrupted | -0.247000 | no TS |
14.530000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr6:g.32517633C>A | COSN14722336 | CHC322T | [liver][NS][carcinoma][hepatocellular_carcinoma] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-1200 |
tttCTCAGGAcctggttgc |
0 | CUCCUGAG | m7b | (m6c->m7b) | no TS | -0.186000 |
-0.480000 |
| hsa-miR-2861 |
tttctCAGGCCCtggttgc |
1 |
GGGGCCUG | m7b | Disrupted | -0.262000 | no TS | No effect |
| hsa-miR-3918 |
tttctcaGGCCCTGgttgc |
1 |
ACAGGGCC | m7b | Disrupted | -0.264000 | no TS |
4.640000 |
| hsa-miR-4512 |
tttctcAGGCCCTGgttgc |
1 |
CAGGGCCU | m8a | Disrupted | -0.216000 | no TS |
1.750000 |
| hsa-miR-4685-5p |
tttctcagGCCCTGGttgc |
1 |
CCCAGGGC | m7b | Disrupted | -0.247000 | no TS |
14.530000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 32517389 | rs192797755 | A | A |
hsa-miR-511-5p hsa-miR-6830-3p hsa-miR-9-5p |
2 2 2 |
ctccAAAGACAAa ctccAAAGACAaa ctCCAAAGAcaaa |
Disrupted Disrupted Disrupted |
N N N |
-0.211 -0.074 -0.081 |
| G |
hsa-miR-212-5p hsa-miR-2355-3p hsa-miR-3189-3p hsa-miR-432-5p hsa-miR-4646-3p hsa-miR-676-3p |
2 2 2 2 2 2 |
ctCCAAGGAcaaa ctccaAGGACAAA ctCCAAGGAcaaa CTCCAAGgacaaa ctccaaGGACAAA ctccaAGGACAAa |
Created Created Created Created Created Created |
N N N N N N |
-0.134 -0.393 -0.143 -0.167 -0.161 -0.156 |
|||
| 32517469 | rs3208426 | C | C |
hsa-miR-4716-3p hsa-miR-4723-5p hsa-miR-5698 hsa-miR-6794-5p hsa-miR-6798-5p hsa-miR-6870-5p hsa-miR-7111-5p |
1 1 1 1 1 1 1 |
tacTCCCCCTgtg taCTCCCCCtgtg taCTCCCCCtgtg tacTCCCCCTgtg tactCCCCCTGtg taCTCCCCCtgtg taCTCCCCCtgtg |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N |
-0.248 -0.309 -0.291 -0.22 -0.284 -0.263 -0.291 |
| T |
hsa-miR-4459 hsa-miR-765 |
1 1 |
tactCCTCCTGtg taCTCCTCCtgtg |
Created Created |
N N |
-0.204 -0.228 |
|||
| 32517470 | rs1141880 | C | C |
hsa-miR-4716-3p hsa-miR-4723-5p hsa-miR-5698 hsa-miR-6794-5p hsa-miR-6798-5p hsa-miR-6870-5p hsa-miR-7111-5p |
1 1 1 1 1 1 1 |
gtacTCCCCCTgt gtaCTCCCCCtgt gtaCTCCCCCtgt gtacTCCCCCTgt gtactCCCCCTGt gtaCTCCCCCtgt gtaCTCCCCCtgt |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N |
-0.248 -0.309 -0.291 -0.22 -0.284 -0.263 -0.291 |
| A |
hsa-miR-1911-5p |
2 |
GTACTCAccctgt |
Created |
N |
-0.131 |
|||
| 32517494 | rs3205681 | A | A |
hsa-miR-296-3p |
1 |
AACCCTAcggcct |
Disrupted |
N |
-0.104 |
| C |
hsa-miR-4743-5p |
1 |
aacccTCCGGCCt |
Created |
N |
-0.274 |
|||
| 32517497 | rs3208424 | C | C |
hsa-miR-296-3p |
1 |
cctAACCCTAcgg |
Disrupted |
N |
-0.104 |
| 32517498 | rs1137472 | C | C |
hsa-miR-296-3p |
1 |
acctAACCCTAcg |
Disrupted |
N |
-0.104 |
| A |
hsa-miR-329-5p hsa-miR-4464 hsa-miR-4748 hsa-miR-6509-5p |
1 1 1 1 |
acctAAACCTAcg acctAAACCTAcg acctAAACCTAcg ACCTAAAcctacg |
Created Created Created Created |
N N N N |
-0.017 -0.024 -0.03 -0.146 |
|||
| 32517632 | rs142706861 | C | C |
hsa-miR-2861 hsa-miR-3918 hsa-miR-4512 hsa-miR-4685-5p hsa-miR-6753-5p hsa-miR-6837-5p |
1 1 1 1 1 1 |
tCAGGCCCtggtt tcaGGCCCTGgtt tcAGGCCCTggtt tcagGCCCTGGtt tcaggCCCTGGTt tcagGCCCTGGtt |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
-0.262 -0.264 -0.216 -0.247 -0.196 -0.237 |
| T |
hsa-miR-4293 |
1 |
TCAGGCTctggtt |
Created |
N |
-0.18 |
|||
| 32517633 | rs151002802 | C | C |
hsa-miR-2861 hsa-miR-3918 hsa-miR-4512 hsa-miR-4685-5p hsa-miR-6753-5p hsa-miR-6837-5p |
1 1 1 1 1 1 |
ctCAGGCCCtggt ctcaGGCCCTGgt ctcAGGCCCTggt ctcagGCCCTGGt ctcaggCCCTGGT ctcagGCCCTGGt |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
-0.262 -0.264 -0.216 -0.247 -0.196 -0.237 |
| A |
hsa-miR-1200 hsa-miR-4324 hsa-miR-544b |
1 1 1 |
CTCAGGAcctggt CTCAGGAcctggt CTCAGGAcctggt |
Created Created Created |
N N N |
-0.186 -0.181 -0.107 |
|||
| 32517639 | rs182782374 | C | C |
hsa-miR-4251 hsa-miR-4324 hsa-miR-539-5p |
6 6 7 |
gactTTCTCAGgc gacttTCTCAGGc gacTTTCTCAggc |
Disrupted Disrupted Disrupted |
N N N |
-0.081 -0.169 -0.015 |