SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001243965
Gene Symbol: HLA-DRB1
Description: Homo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), transcript variant 2, mRNA.
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr6:g.32578926T>C 9_58967 CRC-6-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-185-3p ttcctCAGCCCCTgccctt
 4
 AGGGGCUG m8a Created no TS -0.209 -2.58
hsa-miR-1909-3p ttcctcagCCCCTGCcctt
 4
 CGCAGGGG m7b Created no TS -0.174 -2.64
hsa-miR-28-5p ttcctcAGCTCCTgccctt
 4
 AAGGAGCU m7b Disrupted -0.106 no TS 4.17
hsa-miR-3139 ttcctcAGCTCCTgccctt
 4
 UAGGAGCU m7b Disrupted -0.115 no TS 6.53
hsa-miR-3160-3p ttccTCAGCTCctgccctt
 5
 AGAGCUGA m7b Disrupted -0.103 no TS 4.76
hsa-miR-4656 ttccTCAGCCCctgccctt
 5
 UGGGCUGA m7b Created no TS -0.139 -2.72
hsa-miR-4722-5p ttcctcagCTCCTGCCctt
 4
 GGCAGGAG m8a Disrupted -0.145 no TS 0.01
hsa-miR-708-5p ttcctcAGCTCCTgccctt
 4
 AAGGAGCU m7b Disrupted -0.106 no TS 5.99


Mutation Mutation ID Sample Name Cancer Type
chr6:g.32578981G>A 0_257 Prostate cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr6:g.32579041G>A COSN167736 GC8_T [stomach][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1298 gctttgcaGAATGAAaagc
 0 UUCAUUCG m7a Created no TS -0.066000 -0.020000
hsa-miR-2276 gctTTGCAGAatgaaaagc
 0 UCUGCAAG m7a (m6b->m7a) no TS -0.095000 -3.030000
hsa-miR-4772-3p gctTTGCAGGatgaaaagc
 0 CCUGCAAC m7a (m7a->m6b) no TS -0.087000 -3.030000
hsa-miR-4793-5p gctttgCAGGATGaaaagc
 0 ACAUCCUG m7b Disrupted -0.383000 no TS 3.570000
hsa-miR-5196-3p gctttgcAGGATGAaaagc
 0 UCAUCCUC m7a Disrupted -0.121000 no TS -4.410000
hsa-miR-544a gcttTGCAGAATgaaaagc
 0 AUUCUGCA m8a Created -0.232000 -0.411000 -3.270000
hsa-miR-1298 gctttgcaGAATGAAaagc
 0 UUCAUUCG m7a Created no TS -0.066 -0.02
hsa-miR-2276 gctTTGCAGAatgaaaagc
 0 UCUGCAAG m7a (m6b->m7a) no TS -0.095 -3.03
hsa-miR-4772-3p gctTTGCAGGatgaaaagc
 0 CCUGCAAC m7a (m7a->m6b) no TS -0.087 -3.03
hsa-miR-4793-5p gctttgCAGGATGaaaagc
 0 ACAUCCUG m7b Disrupted -0.383 no TS 3.57
hsa-miR-5196-3p gctttgcAGGATGAaaagc
 0 UCAUCCUC m7a Disrupted -0.121 no TS -4.41
hsa-miR-544a gcttTGCAGAATgaaaagc
 0 AUUCUGCA m8a Created -0.232 -0.411 -3.27

Mutation Mutation ID Sample Name Cancer Type
chr6:g.32579051G>A COSN167737 GC8_T [stomach][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-320a ttctgcccCAGCTTTgcag
 0 AAAAGCUG m7b Created no TS -0.071000 -0.010000
hsa-miR-320b ttctgcccCAGCTTTgcag
 0 AAAAGCUG m7b Created no TS -0.071000 -0.010000
hsa-miR-320c ttctgcccCAGCTTTgcag
 0 AAAAGCUG m7b Created no TS -0.071000 -0.040000
hsa-miR-320d ttctgcccCAGCTTTgcag
 0 AAAAGCUG m7b Created no TS -0.071000 -0.360000
hsa-miR-320e ttctgccCCAGCTTTgcag
 0 AAAGCUGG m8a Created no TS -0.182000 -0.100000
hsa-miR-4429 ttctgcccCAGCTTTgcag
 0 AAAAGCUG m7b Created no TS -0.071000 -0.010000
hsa-miR-4731-5p ttctgCCCCAGCtttgcag
 0 UGCUGGGG m7b Created -0.143000 -0.381000 No effect
hsa-miR-486-3p ttCTGCCCCGgctttgcag
 0 CGGGGCAG m8a (m8a->m7b) -0.286000 -0.522000 No effect
hsa-miR-5090 ttcTGCCCCGGctttgcag
 0 CCGGGGCA m8a Disrupted -0.311000 no TS 1.960000
hsa-miR-320a ttctgcccCAGCTTTgcag
 0 AAAAGCUG m7b Created no TS -0.071 -0.01
hsa-miR-320b ttctgcccCAGCTTTgcag
 0 AAAAGCUG m7b Created no TS -0.071 -0.01
hsa-miR-320c ttctgcccCAGCTTTgcag
 0 AAAAGCUG m7b Created no TS -0.071 -0.04
hsa-miR-320d ttctgcccCAGCTTTgcag
 0 AAAAGCUG m7b Created no TS -0.071 -0.36
hsa-miR-320e ttctgccCCAGCTTTgcag
 0 AAAGCUGG m8a Created no TS -0.182 -0.1
hsa-miR-4429 ttctgcccCAGCTTTgcag
 0 AAAAGCUG m7b Created no TS -0.071 -0.01
hsa-miR-4731-5p ttctgCCCCAGCtttgcag
 0 UGCUGGGG m7b Created -0.143 -0.381 No effect
hsa-miR-486-3p ttCTGCCCCGgctttgcag
 0 CGGGGCAG m8a (m8a->m7b) -0.286 -0.522 No effect
hsa-miR-5090 ttcTGCCCCGGctttgcag
 0 CCGGGGCA m8a Disrupted -0.311 no TS 1.96

Mutation Mutation ID Sample Name Cancer Type
chr6:g.32579055C>T COSN167738 GC8_T [stomach][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-486-3p aactttCTGCCCCGgcttt
 0 CGGGGCAG m8a Disrupted -0.286000 no TS 0.070000
hsa-miR-5090 aactttcTGCCCCGGcttt
 0 CCGGGGCA m8a Disrupted -0.311000 no TS 1.230000
hsa-miR-486-3p aactttCTGCCCCGgcttt
 0 CGGGGCAG m8a Disrupted -0.286 no TS 0.07
hsa-miR-5090 aactttcTGCCCCGGcttt
 0 CCGGGGCA m8a Disrupted -0.311 no TS 1.23

Mutation Mutation ID Sample Name Cancer Type
chr6:g.32579061T>C COSN167739 GC8_T [stomach][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-148a-5p aggaAGAACTTTctgcccc
 0 AAAGUUCU m8a Disrupted -0.088000 no TS 4.350000
hsa-miR-22-5p agGAAGAACTttctgcccc
 0 AGUUCUUC m8a (m8a->m7b) -0.137000 -0.109000 1.100000
hsa-miR-298 aggaagaacCTTCTGCccc
 0 AGCAGAAG m7b (m6b->m7b) no TS -0.090000 No effect
hsa-miR-5584-3p aggAAGAACTttctgcccc
 0 UAGUUCUU m7b (m7b->m6c) -0.099000 no TS 1.070000
hsa-miR-148a-5p aggaAGAACTTTctgcccc
 0 AAAGUUCU m8a Disrupted -0.088 no TS 4.35
hsa-miR-22-5p agGAAGAACTttctgcccc
 0 AGUUCUUC m8a (m8a->m7b) -0.137 -0.109 1.1
hsa-miR-298 aggaagaacCTTCTGCccc
 0 AGCAGAAG m7b (m6b->m7b) no TS -0.09 No effect
hsa-miR-5584-3p aggAAGAACTttctgcccc
 0 UAGUUCUU m7b (m7b->m6c) -0.099 no TS 1.07

Mutation Mutation ID Sample Name Cancer Type
chr6:g.32579076C>- ICGC_ssm_v2_14276 HX5T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-133a agatGACCAAttcaagga
 0 UUUGGUCC m6b Created NA NA No effect
hsa-miR-133b agatGACCAAttcaagga
 0 UUUGGUCC m6b Created NA NA No effect
hsa-miR-183-3p agatgaccAATTCAagga
 0 GUGAAUUA m6b Created no TS 0.000000 No effect
hsa-miR-4452 agatgaccAATTCAAgga
 0 UUGAAUUC m7a Created no TS 0.000000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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