SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001242758
Gene Symbol:	HLA-A
Description:	Homo sapiens major histocompatibility complex, class I, A (HLA-A), transcript variant 2, mRNA.
Gene Location:	chr6(+):29910246-29913661
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Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.29945576T>C			COSN1330872		HX16T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1271-3p	gtgtAGGCACaatgtgagg	0	AGUGCCUG	m6b	Created	no TS	-0.138000	-12.740000
hsa-miR-323a-3p	gtgtaggcaTAATGTGagg	0	CACAUUAC	m7a	(m7a->m6b)	NA	NA	-1.810000
hsa-miR-4289	gtgtaggCACAATGtgagg	0	GCAUUGUG	m7b	Created	no TS	-0.063000	-0.570000
hsa-miR-4633-5p	gtgtAGGCATAatgtgagg	2	AUAUGCCU	m7b	Disrupted	-0.313000	no TS	3.570000
hsa-miR-532-5p	gtgtAGGCATaatgtgagg	2	CAUGCCUU	m6b	Disrupted	-0.118000	no TS	8.140000
hsa-miR-550a-3-5p	gtgtAGGCACaatgtgagg	0	AGUGCCUG	m6b	Created	no TS	-0.138000	-2.900000
hsa-miR-550a-5p	gtgtAGGCACaatgtgagg	0	AGUGCCUG	m6b	Created	no TS	-0.138000	-4.150000
hsa-miR-550b-2-5p	gtgtAGGCACAatgtgagg	0	AUGUGCCU	m7b	Created	no TS	-0.399000	-0.580000
hsa-miR-1271-3p	gtgtAGGCACaatgtgagg	0	AGUGCCUG	m6b	Created	no TS	-0.138	-12.74
hsa-miR-323a-3p	gtgtaggcaTAATGTGagg	0	CACAUUAC	m7a	(m7a->m6b)	NA	NA	-1.81
hsa-miR-4289	gtgtaggCACAATGtgagg	0	GCAUUGUG	m7b	Created	no TS	-0.063	-0.57
hsa-miR-4633-5p	gtgtAGGCATAatgtgagg	2	AUAUGCCU	m7b	Disrupted	-0.313	no TS	3.57
hsa-miR-532-5p	gtgtAGGCATaatgtgagg	2	CAUGCCUU	m6b	Disrupted	-0.118	no TS	8.14
hsa-miR-550a-3-5p	gtgtAGGCACaatgtgagg	0	AGUGCCUG	m6b	Created	no TS	-0.138	-2.9
hsa-miR-550a-5p	gtgtAGGCACaatgtgagg	0	AGUGCCUG	m6b	Created	no TS	-0.138	-4.15
hsa-miR-550b-2-5p	gtgtAGGCACAatgtgagg	0	AUGUGCCU	m7b	Created	no TS	-0.399	-0.58

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.29945578A>G			COSN1330873		HX16T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-130a-5p	gtaggcatAATGTGAggag	5	UUCACAUU	m7b	Disrupted	-0.075000	no TS	3.530000
hsa-miR-23a-3p	gtaggcatAATGTGAggag	5	AUCACAUU	m7b	Disrupted	-0.038000	no TS	3.530000
hsa-miR-23b-3p	gtaggcatAATGTGAggag	5	AUCACAUU	m7b	Disrupted	-0.038000	no TS	3.520000
hsa-miR-23c	gtaggcatAATGTGAggag	5	AUCACAUU	m7b	Disrupted	-0.038000	no TS	3.520000
hsa-miR-323a-3p	gtaggcaTAATGTGaggag	0	CACAUUAC	m7a	Disrupted	NA	NA	-1.810000
hsa-miR-342-3p	gtaggcataGTGTGAGgag	0	UCUCACAC	m7b	(m6c->m7b)	no TS	-0.144000	1.380000
hsa-miR-130a-5p	gtaggcatAATGTGAggag	0	UUCACAUU	m7b	Disrupted	-0.075	no TS	3.53
hsa-miR-23a-3p	gtaggcatAATGTGAggag	0	AUCACAUU	m7b	Disrupted	-0.038	no TS	3.53
hsa-miR-23b-3p	gtaggcatAATGTGAggag	0	AUCACAUU	m7b	Disrupted	-0.038	no TS	3.52
hsa-miR-23c	gtaggcatAATGTGAggag	0	AUCACAUU	m7b	Disrupted	-0.038	no TS	3.52
hsa-miR-323a-3p	gtaggcaTAATGTGaggag	0	CACAUUAC	m7a	Disrupted	NA	NA	-1.81
hsa-miR-342-3p	gtaggcataGTGTGAGgag	0	UCUCACAC	m7b	(m6c->m7b)	no TS	-0.144	1.38

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.29945718G>A			COSN6513647		BN37T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-767-5p	caacttcATGGTGCActga	2	UGCACCAU	m8a	Disrupted	-0.355000	no TS	4.080000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
29945862	rs2975052	A	A	hsa-miR-6740-3p	6	tgGAAGACAtgag	Disrupted	N	-0.132
			G	hsa-miR-4297 hsa-miR-532-5p hsa-miR-5581-5p	5 21 5	tGGAAGGCAtgag tggAAGGCATgag tGGAAGGCAtgag	Created Created Created	N N N	-0.534 -0.169 -0.513

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