SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_021072
Gene Symbol: HCN1
Description: Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 1 (HCN1), mRNA.
Gene Location: chr5(-):45259351-45696220
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr5:g.45255210T>G COSN9952035 C0001T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3163 atgttataATTTTATcctg
 12
 UAUAAAAU m7b Disrupted 1.471000 1.423000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45255307G>T COSN4947739 SS6003125 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3925-3p acatttCTGGAGatgacaa
 0 ACUCCAGU m6b Disrupted -0.134000 no TS 0.680000
hsa-miR-520a-5p acattTCTGGAGatgacaa
 0 CUCCAGAG m7a Disrupted -0.010000 -0.010000 0.660000
hsa-miR-525-5p acattTCTGGAGatgacaa
 0 CUCCAGAG m7a Disrupted -0.003000 -0.003000 0.060000
hsa-miR-766-3p acatttCTGGAGatgacaa
 0 ACUCCAGC m6b Disrupted -0.111000 -0.002000 0.020000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45255465C>G COSN192180 PD4005a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4431 tgcAGAGTCGttggcctta
 0 GCGACUCU m7b (m6c->m7b) no TS -0.213000 -0.610000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45255621T>C COSN2107997 RK051_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3147 ttgtttGCCCAACtcttct
 0 GGUUGGGC m7b Created no TS -0.257000 -0.910000
hsa-miR-4259 ttgtttgCCCAACTcttct
 5
 CAGUUGGG m7b Created -0.043000 -0.188000 -0.010000
hsa-miR-4423-3p ttgttTGCCTAactcttct
 14
 AUAGGCAC m6b Disrupted -0.242000 -0.118000 0.010000
hsa-miR-571 ttgtttgcCCAACTCttct
 11
 UGAGUUGG m7b Created -0.118000 -0.263000 -0.430000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45255836A>G COSN6298773 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2682-3p cagatgtgtAGAGGCaaag
 0 CGCCUCUU m6b Disrupted -0.104000 no TS No effect
hsa-miR-466 cagATGTGTAgaggcaaag
 0 AUACACAU m7b (m7b->m6c) -0.068000 -0.099000 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45255889A>T COSN9309106 8057646 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4668-3p aataacGGATTTTtgcaaa
 13
 GAAAAUCC m7b Created 0.192000 0.191000 No effect
hsa-miR-548c-3p aataacgGATTTTTGcaaa
 0 CAAAAAUC m8a Created 1.404000 1.525000 -0.070000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45256031T>C COSN7943847 8012321 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-15b-3p gaatactatTGATTCattc
 0 CGAAUCAU m6b Disrupted -0.157000 -0.138000 4.600000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45256445C>A COSN4947740 SS6003311 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-515-5p tctTTGGAGAtattatatt
 2
 UUCUCCAA m7b (m6c->m7b) -0.079000 -0.122000 0.260000
hsa-miR-519e-5p tctTTGGAGAtattatatt
 2
 UUCUCCAA m7b (m6c->m7b) -0.048000 -0.081000 0.210000
hsa-miR-5692b tctttggagATATTATatt
 7
 AAUAAUAU m7b (m6b->m7b) 0.560000 0.667000 No effect
hsa-miR-5692c tctttggagATATTATatt
 7
 AAUAAUAU m7b (m6b->m7b) 0.560000 0.667000 No effect
hsa-miR-889 tctttggaGATATTAtatt
 0 UUAAUAUC m7b Created 0.115000 0.178000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45256540A>T COSN8631436 SS6003317 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1290 tcaagAAAATCCcaaacaa
 0 UGGAUUUU m7b Created no TS 0.085000 0.190000
hsa-miR-3122 tcaagaaaaTCCCAAacaa
 0 GUUGGGAC m6b Created 0.008000 0.020000 -0.140000
hsa-miR-3940-5p tcaagaaaAACCCAaacaa
 0 GUGGGUUG m6b Disrupted -0.415000 -0.413000 5.020000
hsa-miR-4507 tcaagaaaAACCCAaacaa
 0 CUGGGUUG m6b Disrupted -0.422000 -0.413000 3.300000
hsa-miR-450b-3p tcaagaaaATCCCAAacaa
 5
 UUGGGAUC m7a Created -0.013000 -0.035000 -0.820000
hsa-miR-5089 tcaagaaAATCCCAaacaa
 9
 GUGGGAUU m7b Created -0.176000 -0.196000 -3.920000
hsa-miR-629-5p tcaagaaAAACCCAaacaa
 0 UGGGUUUA m7a Disrupted 0.018000 0.014000 1.560000
hsa-miR-769-3p tcaagaaaATCCCAaacaa
 5
 CUGGGAUC m6b Created 0.001000 -0.011000 -1.550000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45256628G>T COSN6298774 RK176_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-148a-5p ggatcgcttGAACTTagga
 0 AAAGUUCU m6b Disrupted 0.119000 no TS 1.000000
hsa-miR-498 ggatcGCTTGAActtagga
 10
 UUUCAAGC m7b Disrupted 0.141000 0.029000 No effect
hsa-miR-518a-3p ggatCGCTTTaacttagga
 0 GAAAGCGC m6b Created no TS -0.022000 -0.020000
hsa-miR-518b ggatCGCTTTaacttagga
 0 CAAAGCGC m6b Created no TS -0.022000 -0.050000
hsa-miR-518c-3p ggatCGCTTTaacttagga
 0 CAAAGCGC m6b Created no TS -0.019000 -0.140000
hsa-miR-518d-3p ggatCGCTTTaacttagga
 0 CAAAGCGC m6b Created no TS -0.022000 -0.010000
hsa-miR-518f-3p ggatCGCTTTaacttagga
 0 GAAAGCGC m6b Created no TS -0.019000 -0.040000
hsa-miR-9-3p ggatcGCTTTAacttagga
 0 AUAAAGCU m6b Created no TS 0.100000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr5:g.45257173C>T COSN7943848 8067226 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr5:g.45257412T>C COSN1316524 HX12T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2355-5p attaaatgCTGGGGAaata
 0 AUCCCCAG m7b Disrupted -0.453000 -0.274000 0.040000
hsa-miR-338-3p attaaATGCTGGggaaata
 4
 UCCAGCAU m7b Disrupted -0.121000 -0.028000 0.340000
hsa-miR-4310 attaAATGCTGgggaaata
 0 GCAGCAUU m7b Disrupted 0.292000 0.303000 0.010000
hsa-miR-4707-5p attaaatGCCGGGGaaata
 0 GCCCCGGC m7b Created no TS -0.395000 -3.290000
hsa-miR-5587-3p attaaatgCCGGGGaaata
 0 GCCCCGGG m6b Created no TS -0.183000 -11.030000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45257510A>G 11_5897 2542 Breast cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1305 ccaccTTGAAAAttattta
 6
 UUUUCAAC m7a Disrupted 0.397 0.248 0.04
hsa-miR-4775 ccaccttgAAAATTAttta
 6
 UUAAUUUU m7b Disrupted 0.915 0.681 No effect
hsa-miR-498 ccacCTTGAAAattattta
 6
 UUUCAAGC m7a Disrupted 0.141 0.054 0.02
hsa-miR-513c-5p ccacCTTGAGAAttattta
 6
 UUCUCAAG m8a Created no TS 0.086 -3.14
hsa-miR-514b-5p ccacCTTGAGAAttattta
 6
 UUCUCAAG m8a Created no TS 0.075 -2.53
hsa-miR-5571-5p ccaccttGAGAATTattta
 6
 CAAUUCUC m7b Created -0.098 0.008 -0.01
hsa-miR-590-3p ccaccttgAAAATTAttta
 6
 UAAUUUUA m7a Disrupted 1.044 0.817 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45257607A>G COSN14938306 LP6007544-DNA_A01 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-338-3p ctaATGCTGGccctgcttc
 4
 UCCAGCAU m7b (m6c->m7b) -0.121000 -0.097000 -1.690000
hsa-miR-3918 ctaatgctGGCCCTGcttc
 0 ACAGGGCC m7b Created -0.157000 -0.223000 -12.360000
hsa-miR-4640-5p ctaatgCTGGCCCtgcttc
 0 UGGGCCAG m7b Created -0.033000 -0.076000 -0.210000
hsa-miR-4726-5p ctaatgCTGGCCCTgcttc
 0 AGGGCCAG m8a Created -0.043000 -0.077000 -0.050000


Mutation Mutation ID Sample Name Cancer Type
chr5:g.45257728G>A COSN6298775 RK028_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr5:g.45258059T>G COSN7943849 8066852 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4662a-3p cattaTATCTTTatctttt
 0 AAAGAUAG m7a Disrupted -0.039000 -0.039000 No effect
hsa-miR-577 cattatatcTTTATCTttt
 0 UAGAUAAA m7b (m7b->m6b) 0.075000 no TS 0.040000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45258218T>G COSN6298776 RK185_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3976 tgagcaaTCTCTATtatct
 8
 UAUAGAGA m7b Disrupted -0.227000 -0.209000 1.950000
hsa-miR-5186 tgagCAATCTCTattatct
 0 AGAGAUUG m8a Disrupted -0.026000 no TS 6.430000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45258524G>C COSN9952036 C0073T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-370 gaaaacaAGCAGGataaat
 0 GCCUGCUG m6b Created no TS -0.037000 -0.040000
hsa-miR-660-3p gaaaacaAGGAGGataaat
 0 ACCUCCUG m6b Disrupted 0.013000 0.028000 0.130000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45258642A>C COSN7943850 8066440 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1207-5p gggCCCTGCCAagttattt
 0 UGGCAGGG m8a Created -0.061000 -0.142000 No effect
hsa-miR-4736 gggcCCTGCCaagttattt
 0 AGGCAGGU m6b Created no TS -0.040000 No effect
hsa-miR-4763-3p gggCCCTGCCaagttattt
 0 AGGCAGGG m7b (m6c->m7b) -0.052000 -0.144000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45259046T>A COSN9448637 AOCS-158-1-6 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-224-3p ttgtttACCATTTTcgtat
 13
 AAAAUGGU m8a Created 0.295000 0.310000 -0.460000
hsa-miR-522-3p ttgtttACCATTTTcgtat
 13
 AAAAUGGU m8a Created 0.262000 0.287000 -0.280000
hsa-miR-548ag ttgtTTACCTTTttcgtat
 0 AAAGGUAA m8a Disrupted -0.017000 no TS 0.390000
hsa-miR-548ai ttgtTTACCTTTttcgtat
 0 AAAGGUAA m8a Disrupted -0.008000 no TS 0.010000
hsa-miR-548m ttgttTACCTTTttcgtat
 0 CAAAGGUA m7b Disrupted -0.012000 no TS 0.450000
hsa-miR-570-5p ttgtTTACCTTTttcgtat
 0 AAAGGUAA m8a Disrupted -0.008000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45259055T>G COSN9952037 C0068T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-495 accacttcTTTGTTTacct
 0 AAACAAAC m7a Disrupted 0.414000 0.414000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45259152C>A COSN6298777 RK197_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-203 taaaATTTCAaagagctta
 0 GUGAAAUG m6b Created 0.526000 0.641000 No effect
hsa-miR-3978 taaaaTTTCCAagagctta
 0 GUGGAAAG m6b Disrupted 0.051000 -0.020000 No effect
hsa-miR-5093 taaaATTTCCaagagctta
 0 AGGAAAUG m6b Disrupted 0.071000 no TS 3.110000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45259153C>A COSN6298778 RK197_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3978 ataaaaTTTCCAagagctt
 0 GUGGAAAG m6b Disrupted 0.051000 -0.020000 No effect
hsa-miR-5093 ataaaATTTCCaagagctt
 0 AGGAAAUG m6b Disrupted 0.071000 no TS 3.110000
hsa-miR-643 ataaaattTACAAGagctt
 0 ACUUGUAU m6b Created 0.037000 0.072000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45259581A>G 9_87789 CRC-8-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-10a-5p gtACAGGGTAaattatata
 30
 UACCCUGU m8a (m8a->m7b) -0.208 -0.151 1.86
hsa-miR-10b-5p gtACAGGGTAaattatata
 30
 UACCCUGU m8a (m8a->m7b) -0.218 -0.16 0.38
hsa-miR-32-3p gtacagggTAAATTatata
 24
 CAAUUUAG m6b Disrupted 0.485 0.323 0.02
hsa-miR-3620 gtaCAGGGTGAattatata
 31
 UCACCCUG m8a Created -0.062 -0.253 No effect
hsa-miR-4760-3p gtacagggTGAATTatata
 24
 AAAUUCAU m6b Created 0.108 0.221 -0.01

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45259805T>C COSN4850292 tumor_4121361 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4475 tattgGTCCCTTaaattat
 13
 CAAGGGAC m7b Created 0.000000 -0.097000 -3.980000
hsa-miR-4477b tattggtcCCTTAAattat
 0 AUUAAGGA m6b Created 0.047000 0.096000 -0.150000


Mutation Mutation ID Sample Name Cancer Type
chr5:g.45259816C>A COSN1316525 HX10T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr5:g.45259887C>A COSN8492844 2296_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-224-3p ctgcaagACCATTTacata
 13
 AAAAUGGU m7b Disrupted 0.295000 0.144000 0.010000
hsa-miR-431-5p ctGCAAGACAatttacata
 18
 UGUCUUGC m8a (m7b->m8a) -0.036000 -0.075000 -0.290000
hsa-miR-4694-3p ctgcaagaCCATTTacata
 14
 CAAAUGGA m6b Disrupted 0.220000 0.101000 No effect
hsa-miR-511 ctgcAAGACAatttacata
 0 GUGUCUUU m6b Created no TS 0.072000 No effect
hsa-miR-522-3p ctgcaagACCATTTacata
 13
 AAAAUGGU m7b Disrupted 0.262000 0.122000 0.020000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45259895T>C COSN8492845 J46_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1301 tgggaaAGCTGCAAgacca
 14
 UUGCAGCU m8a Disrupted -0.059000 no TS 0.040000
hsa-miR-4660 tgggaaAGCTGCAagacca
 14
 UGCAGCUC m7a Disrupted -0.011000 no TS 0.040000
hsa-miR-5047 tgggaaAGCTGCAAgacca
 14
 UUGCAGCU m8a Disrupted -0.069000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45259978T>G 9_87790 CRC-8-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1279 aatcatCAATATGctggtg
 3
 UCAUAUUG m7b Disrupted 0.343 0.268 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45259987A>C COSN2107999 RK023_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1272 atgtaatgTCATCATCaat
 0 GAUGAUGA m8a Created 0.024000 0.079000 -0.060000
hsa-miR-1322 atgtaatgtCATCATCaat
 0 GAUGAUGC m7a (m6a->m7a) 0.014000 0.014000 No effect
hsa-miR-1272 atgtaatgTCATCATCaat
 0 GAUGAUGA m8a Created 0.024 0.079 -0.06
hsa-miR-1322 atgtaatgtCATCATCaat
 0 GAUGAUGC m7a (m6a->m7a) 0.014 0.014 No effect


Mutation Mutation ID Sample Name Cancer Type
chr5:g.45260022G>A COSN8492846 699_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr5:g.45260342C>G COSN15462472 AOCS-171-1-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3622a-5p catttGTGCCTaatgcatc
 15
 CAGGCACG m6b Disrupted -0.232000 -0.173000 1.240000
hsa-miR-4423-3p catttGTGCCTAatgcatc
 14
 AUAGGCAC m7b Disrupted -0.242000 -0.124000 1.010000
hsa-miR-521 catttGTGCGTaatgcatc
 0 AACGCACU m6b Created no TS -0.121000 -0.230000
hsa-miR-5582-5p cattTGTGCCTAatgcatc
 15
 UAGGCACA m8a Disrupted -0.153000 -0.061000 0.510000
hsa-miR-3622a-5p catttGTGCCTaatgcatc
 15
 CAGGCACG m6b Disrupted -0.232000 -0.173000 1.240000
hsa-miR-4423-3p catttGTGCCTAatgcatc
 14
 AUAGGCAC m7b Disrupted -0.242000 -0.124000 1.010000
hsa-miR-521 catttGTGCGTaatgcatc
 0 AACGCACU m6b Created no TS -0.121000 -0.230000
hsa-miR-5582-5p cattTGTGCCTAatgcatc
 15
 UAGGCACA m8a Disrupted -0.153000 -0.061000 0.510000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45260748C>T COSN8492847 J87_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-106a-5p aggttttCACTTTTattta
 0 AAAAGUGC m7a Disrupted 0.214000 0.214000 No effect
hsa-miR-3609 aggtttTCACTTTtattta
 13
 CAAAGUGA m7b Disrupted 0.059000 0.107000 No effect
hsa-miR-3646 aggttTTCATTTTtattta
 0 AAAAUGAA m8a Created 0.125000 0.165000 No effect
hsa-miR-3662 aggtttTCATTTTtattta
 7
 GAAAAUGA m7b Created 0.224000 0.262000 0.090000
hsa-miR-548ah-5p aggtttTCACTTTTattta
 13
 AAAAGUGA m8a Disrupted 0.067000 0.106000 No effect
hsa-miR-548c-3p aggttttcATTTTTattta
 0 CAAAAAUC m6b Created 1.404000 1.557000 -0.010000
hsa-miR-548n aggttttcACTTTTattta
 11
 CAAAAGUA m6b Disrupted 0.317000 0.236000 No effect
hsa-miR-548t-5p aggttttCACTTTTattta
 11
 CAAAAGUG m7b Disrupted 0.255000 0.228000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45260945T>C COSN8631437 SS6003317 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-31-5p tctttctTCTTGCCataat
 12
 AGGCAAGA m7b Disrupted -0.212000 no TS 4.380000
hsa-miR-4722-5p tctttctTCCTGCCataat
 0 GGCAGGAG m7a Created -0.132000 -0.132000 -0.030000
hsa-miR-4736 tctttcttCCTGCCataat
 0 AGGCAGGU m6b Created no TS -0.110000 -1.640000
hsa-miR-4763-3p tctttcttCCTGCCataat
 0 AGGCAGGG m6b Created -0.052000 -0.145000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45260954T>G COSN14923630 LP6005409-DNA_F03 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3973 cgtTACTTTGctttcttct
 0 ACAAAGUA m7b (m6c->m7b) 0.053000 0.030000 No effect
hsa-miR-548a-5p cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.453000 0.480000 -0.190000
hsa-miR-548ab cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.447000 0.474000 0.070000
hsa-miR-548ak cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.437000 0.464000 -2.260000
hsa-miR-548am-5p cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.437000 0.464000 -2.610000
hsa-miR-548ap-5p cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.465000 0.492000 -1.140000
hsa-miR-548ar-5p cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.418000 0.445000 -0.710000
hsa-miR-548as-5p cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.469000 0.496000 -0.050000
hsa-miR-548au-5p cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.437000 0.464000 -3.140000
hsa-miR-548b-5p cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.424000 0.451000 0.010000
hsa-miR-548c-5p cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.437000 0.464000 -2.610000
hsa-miR-548d-5p cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.434000 0.461000 -0.010000
hsa-miR-548h-5p cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.437000 0.464000 -2.470000
hsa-miR-548i cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.451000 0.478000 -0.780000
hsa-miR-548j cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.455000 0.482000 -3.200000
hsa-miR-548n cgtTACTTTTctttcttct
 11
 CAAAAGUA m7b (m7b->m6c) 0.317000 0.282000 0.250000
hsa-miR-548o-5p cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.437000 0.464000 -2.610000
hsa-miR-548w cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.437000 0.464000 -1.270000
hsa-miR-548y cgTTACTTTTctttcttct
 13
 AAAAGUAA m8a (m8a->m7b) 0.420000 0.447000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45261249G>A COSN8492848 422_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-369-3p tcttcatGTATTATcggac
 14
 AAUAAUAC m7b Created 0.428000 0.434000 -0.340000
hsa-miR-374c-5p tcttcaTGTATTATcggac
 18
 AUAAUACA m8a Created 0.030000 0.024000 No effect
hsa-miR-4643 tcttCATGTGTtatcggac
 9
 GACACAUG m7b Disrupted -0.205000 -0.052000 3.200000
hsa-miR-655 tcttcaTGTATTATcggac
 18
 AUAAUACA m8a Created 0.016000 0.001000 -0.420000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45261427T>G COSN7943852 8062308 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-3p aatcccaTTGTATAGatct
 0 CUAUACAA m8a Created 0.245000 0.184000 -1.730000
hsa-let-7b-3p aatcccaTTGTATAGatct
 0 CUAUACAA m8a Created 0.266000 0.224000 -0.200000
hsa-let-7f-1-3p aatcccaTTGTATAGatct
 0 CUAUACAA m8a Created 0.206000 0.145000 -0.220000
hsa-let-7f-2-3p aatcccatTGTATAGatct
 0 CUAUACAG m7a Created 0.084000 0.084000 -0.030000
hsa-miR-1284 aatcccatTGTATAGAtct
 0 UCUAUACA m8a Created 0.010000 -0.227000 -0.240000
hsa-miR-224-3p aatcCCATTTTatagatct
 13
 AAAAUGGU m7a Disrupted 0.295000 0.295000 0.020000
hsa-miR-3163 aatcccATTTTATAgatct
 12
 UAUAAAAU m8a Disrupted 1.471000 1.337000 0.450000
hsa-miR-3662 aatccCATTTTatagatct
 7
 GAAAAUGA m6b Disrupted 0.224000 0.169000 No effect
hsa-miR-4666a-3p aatcccATTGTATagatct
 13
 CAUACAAU m7b Created 0.196000 0.169000 -0.670000
hsa-miR-522-3p aatcCCATTTTatagatct
 13
 AAAAUGGU m7a Disrupted 0.262000 0.262000 0.070000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45261534C>T COSN15470573 AOCS-162-1-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-219-1-3p aaggCAACTCaaatgaact
 11
 AGAGUUGA m6b Disrupted -0.124000 no TS 0.010000
hsa-miR-382-5p aaggCAACTTaaatgaact
 0 GAAGUUGU m6b Created no TS -0.073000 -1.580000
hsa-miR-4729 aaggcaactTAAATGAact
 0 UCAUUUAU m7a (m6a->m7a) -0.039000 -0.013000 No effect
hsa-miR-5696 aaggcaactTAAATGAact
 1
 CUCAUUUA m7b (m6b->m7b) -0.060000 -0.154000 -1.330000
hsa-miR-571 aaggCAACTCAaatgaact
 11
 UGAGUUGG m7a Disrupted -0.118000 no TS 0.320000
hsa-miR-579 aaggcaactCAAATGAAct
 1
 UUCAUUUG m8a (m8a->m7a) -0.160000 -0.026000 No effect
hsa-miR-644b-3p aaggcaactCAAATGAAct
 1
 UUCAUUUG m8a (m8a->m7a) -0.156000 -0.015000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45261535T>A COSN15470558 AOCS-162-1-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-219-1-3p aaaggCAACTCaaatgaac
 11
 AGAGUUGA m6b Disrupted -0.124000 no TS 0.010000
hsa-miR-4423-5p aaAGGCAACTcaaatgaac
 13
 AGUUGCCU m8a (m8a->m7b) -0.272000 -0.418000 -2.690000
hsa-miR-5010-3p aaaggcaACACAAAtgaac
 0 UUUUGUGU m7b Created no TS -0.100000 -0.010000
hsa-miR-571 aaaggCAACTCAaatgaac
 11
 UGAGUUGG m7a Disrupted -0.118000 no TS 0.390000
hsa-miR-599 aaaggcaACACAAatgaac
 0 GUUGUGUC m6b Created no TS -0.059000 -0.400000
hsa-miR-744-3p aaaGGCAACAcaaatgaac
 0 CUGUUGCC m7b (m6c->m7b) no TS -0.267000 -0.240000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45261675T>A COSN2108000 RK042_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-33a-3p ttctttaAAACATTaaagg
 0 CAAUGUUU m7b Created 0.013000 -0.149000 No effect
hsa-miR-409-3p ttctttaaAACATTaaagg
 0 GAAUGUUG m6b Created -0.015000 -0.066000 No effect
hsa-miR-4307 ttctttAAAACATTaaagg
 10
 AAUGUUUU m8a Created 0.146000 0.072000 No effect
hsa-miR-33a-3p ttctttaAAACATTaaagg
 0 CAAUGUUU m7b Created 0.013000 -0.149000 No effect
hsa-miR-409-3p ttctttaaAACATTaaagg
 0 GAAUGUUG m6b Created -0.015000 -0.066000 No effect
hsa-miR-4307 ttctttAAAACATTaaagg
 10
 AAUGUUUU m8a Created 0.146000 0.072000 No effect
hsa-miR-33a-3p ttctttaAAACATTaaagg
 0 CAAUGUUU m7b Created 0.013 -0.149 No effect
hsa-miR-409-3p ttctttaaAACATTaaagg
 0 GAAUGUUG m6b Created -0.015 -0.066 No effect
hsa-miR-4307 ttctttAAAACATTaaagg
 0 AAUGUUUU m8a Created 0.146 0.072 2.3

Mutation Mutation ID Sample Name Cancer Type
chr5:g.45261732A>G COSN8631438 SS6003115 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1343 aaattCCCAGGAGagggtc
 0 CUCCUGGG m8a Created 0.025000 -0.210000 -0.020000
hsa-miR-1976 aaattccCAGGAGagggtc
 0 CCUCCUGC m6b Created -0.017000 -0.136000 -0.010000
hsa-miR-204-3p aaaTTCCCAGgagagggtc
 0 GCUGGGAA m7b (m6c->m7b) no TS -0.227000 -0.570000
hsa-miR-3183 aaattcccaAGAGAGGgtc
 2
 GCCUCUCU m7b (m7b->m6b) -0.218000 -0.020000 0.030000
hsa-miR-4646-5p aaaTTCCCAGgagagggtc
 0 ACUGGGAA m7b (m6c->m7b) no TS -0.227000 -0.230000
hsa-miR-4723-3p aaattcccaAGAGAGGGtc
 2
 CCCUCUCU m8a (m8a->m7a) -0.215000 -0.026000 0.540000
hsa-miR-635 aaattCCCAAGagagggtc
 11
 ACUUGGGC m6b Disrupted -0.203000 -0.043000 0.210000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
45255251 rs187312994 A A hsa-miR-2117
hsa-miR-33a-3p
hsa-miR-409-3p
hsa-miR-4273
hsa-miR-7156-5p
19
19
19
19
19
 GAGAACAttaaat
gagAACATTAaat
gagAACATTAaat
GAGAACAttaaat
GAGAACAttaaat
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.135
0.013
-0.015
-0.128
-0.165
45255386 rs192725740 A A hsa-miR-1305
hsa-miR-335-3p
19
19
 TTGAAAAaattgg
tTGAAAAAattgg
 Disrupted
Disrupted
N
N
 -0.004
0.014
45256392 rs79443250 C
T hsa-miR-33a-3p
19
 AAACATTtttttt
 Created
N
 0.13
45261527 rs950973 A A hsa-miR-3923
hsa-miR-5000-5p
hsa-miR-5696
hsa-miR-579-3p
hsa-miR-664b-3p
hsa-miR-6853-3p
1
2
1
1
1
1
 aaatgaACTAGTA
aaaTGAACTAgta
AAATGAActagta
AAATGAActagta
AAATGAActagta
aAATGAACtagta
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 -0.117
-0.084
0.025
-0.047
-0.048
-0.149
T hsa-miR-28-3p
hsa-miR-5694
1
1
 aaatgATCTAGTA
aaATGATCTAgta
 Created
Created
N
N
 -0.288
-0.263
45261586 rs184765503 A A hsa-miR-3163
8
 tATTTTATgaaga
 Disrupted
N
 0.039
45261626 rs111895144 C C hsa-miR-548az-5p
hsa-miR-548n
hsa-miR-548t-5p
15
13
15
 aacctACTTTTAc
aaccTACTTTTAc
aacctACTTTTAc
 Disrupted
Disrupted
Disrupted
N
N
N
 0.018
-0.054
0.018
T hsa-miR-548c-3p
15
 aacctATTTTTAc
 Created
N
 0.102

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