SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001884
Gene Symbol: HAPLN1
Description: Homo sapiens hyaluronan and proteoglycan link protein 1 (HAPLN1), mRNA.
Gene Location: chr5(-):82934016-83016896
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr5:g.83638425G>A COSN14740387 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr5:g.83638735G>A COSN14869003 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-105-5p aaatatgGCATTTGtaaat
 1
 UCAAAUGC m7b Created -0.019000 -0.123000 -0.030000
hsa-miR-122-3p aaatATGGCGTTtgtaaat
 0 AACGCCAU m8a Disrupted -0.343000 no TS 0.060000
hsa-miR-5590-5p aaaTATGGCAtttgtaaat
 0 UUGCCAUA m7b (m6c->m7b) no TS -0.223000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.83638811G>A COSN5079463 HX24T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4501 aataagttgGTCACATtaa
 4
 UAUGUGAC m7b (m7b->m6b) -0.126000 no TS 5.440000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.83639293C>A COSN4852256 tumor_4177856 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4704-5p ttttccatTAGTGTaaaaa
 0 GACACUAG m6b Created no TS -0.050000 -9.830000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.83639357C>A COSN2119947 RK050_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-361-5p ggtgCTGATAAaaatctct
 0 UUAUCAGA m7a Created no TS 0.003000 -1.620000
hsa-miR-374a-3p ggtgCTGATAAaaatctct
 0 CUUAUCAG m7b Created no TS 0.025000 -0.240000
hsa-miR-383 ggtgCTGATCaaaatctct
 9
 AGAUCAGA m6b Disrupted -0.047000 no TS 0.030000
hsa-miR-4772-5p ggtgCTGATCAaaatctct
 9
 UGAUCAGG m7a Disrupted -0.051000 no TS 0.560000
hsa-miR-361-5p ggtgCTGATAAaaatctct
 0 UUAUCAGA m7a Created no TS 0.003000 -1.620000
hsa-miR-374a-3p ggtgCTGATAAaaatctct
 0 CUUAUCAG m7b Created no TS 0.025000 -0.240000
hsa-miR-383 ggtgCTGATCaaaatctct
 9
 AGAUCAGA m6b Disrupted -0.047000 no TS 0.030000
hsa-miR-4772-5p ggtgCTGATCAaaatctct
 9
 UGAUCAGG m7a Disrupted -0.051000 no TS 0.560000
hsa-miR-361-5p ggtgCTGATAAaaatctct
 0 UUAUCAGA m7a Created no TS 0.003 -1.62
hsa-miR-374a-3p ggtgCTGATAAaaatctct
 0 CUUAUCAG m7b Created no TS 0.025 -0.24
hsa-miR-383 ggtgCTGATCaaaatctct
 0 AGAUCAGA m6b Disrupted -0.047 no TS 0.03
hsa-miR-4772-5p ggtgCTGATCAaaatctct
 0 UGAUCAGG m7a Disrupted -0.051 no TS 0.56

Mutation Mutation ID Sample Name Cancer Type
chr5:g.83639646A>T COSN2119948 RK041_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-136-3p aattaagGATGATacctaa
 2
 CAUCAUCG m6b Created 0.008000 0.011000 -0.690000
hsa-miR-141-5p aattaaGGAAGATacctaa
 1
 CAUCUUCC m7b Disrupted -0.033000 no TS 1.750000
hsa-miR-4793-5p aattaAGGATGatacctaa
 1
 ACAUCCUG m6b Created 0.018000 0.011000 -1.040000
hsa-miR-136-3p aattaagGATGATacctaa
 0 CAUCAUCG m6b Created 0.008 0.011 -0.69
hsa-miR-141-5p aattaaGGAAGATacctaa
 0 CAUCUUCC m7b Disrupted -0.033 no TS 1.75
hsa-miR-4793-5p aattaAGGATGatacctaa
 0 ACAUCCUG m6b Created 0.018 0.011 -1.04

Mutation Mutation ID Sample Name Cancer Type
chr5:g.83640042T>A COSN7581838 8068564 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-181a-5p tcaTGAATGTTtttatgta
 16
 AACAUUCA m8a Disrupted 0.040000 no TS 0.010000
hsa-miR-181b-5p tcaTGAATGTTtttatgta
 16
 AACAUUCA m8a Disrupted 0.040000 no TS No effect
hsa-miR-181c-5p tcaTGAATGTTtttatgta
 16
 AACAUUCA m8a Disrupted 0.040000 no TS No effect
hsa-miR-181d tcaTGAATGTTtttatgta
 16
 AACAUUCA m8a Disrupted 0.040000 no TS No effect
hsa-miR-3163 tcatgaatgATTTTATgta
 12
 UAUAAAAU m7b (m6b->m7b) 0.083000 0.312000 No effect
hsa-miR-382-3p tcatGAATGATTttatgta
 0 AAUCAUUC m8a Created no TS 0.005000 0.070000
hsa-miR-4262 tcaTGAATGTttttatgta
 16
 GACAUUCA m7b (m7b->m6c) 0.022000 no TS 0.340000
hsa-miR-4668-3p tcatgaatGATTTTatgta
 2
 GAAAAUCC m6b Created 0.060000 0.202000 -0.010000
hsa-miR-543 tcatGAATGTTTttatgta
 8
 AAACAUUC m8a Disrupted 0.264000 0.250000 0.230000
hsa-miR-548ac tcatgaatGTTTTTatgta
 0 CAAAAACC m6b Disrupted 0.229000 0.064000 0.140000
hsa-miR-548ae tcatgaatGTTTTTatgta
 0 CAAAAACU m6b Disrupted 0.180000 0.009000 No effect
hsa-miR-548ah-3p tcatgaatGTTTTTatgta
 0 CAAAAACU m6b Disrupted 0.174000 -0.001000 No effect
hsa-miR-548am-3p tcatgaatGTTTTTatgta
 0 CAAAAACU m6b Disrupted 0.174000 -0.001000 No effect
hsa-miR-548aq-3p tcatgaatGTTTTTatgta
 0 CAAAAACU m6b Disrupted 0.180000 0.009000 No effect
hsa-miR-548d-3p tcatgaatGTTTTTatgta
 0 CAAAAACC m6b Disrupted 0.232000 0.064000 No effect
hsa-miR-548h-3p tcatgaatGTTTTTatgta
 0 CAAAAACC m6b Disrupted 0.235000 0.067000 No effect
hsa-miR-548z tcatgaatGTTTTTatgta
 0 CAAAAACC m6b Disrupted 0.235000 0.067000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.83640941C>T COSN7581839 8050103 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1290 ctttAAAATCCtgcctttc
 7
 UGGAUUUU m7b Disrupted -0.026000 0.060000 No effect
hsa-miR-590-3p cttTAAAATTctgcctttc
 12
 UAAUUUUA m7b (m6c->m7b) 0.185000 0.233000 No effect
hsa-miR-940 ctttaaaatCCTGCCTTtc
 7
 AAGGCAGG m8a (m8a->m7a) -0.223000 no TS 5.250000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.83640953A>G COSN2119949 RK170_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1276 gaatattttGCTCTTTAaa
 7
 UAAAGAGC m8a (m7a->m8a) -0.038000 -0.231000 -1.430000
hsa-miR-548p gaataTTTTGCTctttaaa
 0 UAGCAAAA m7b Created 0.054000 -0.042000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.83641326T>C COSN6928929 RK186_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-135a-5p ttgtaAAGCCATcattcaa
 9
 UAUGGCUU m7b Created -0.103000 -0.351000 0.060000
hsa-miR-135b-5p ttgtaAAGCCATcattcaa
 9
 UAUGGCUU m7b Created -0.103000 -0.351000 0.050000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.83641370T>C COSN6928930 RK181_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3662 tgtaaagagTCATTTTCat
 8
 GAAAAUGA m8a (m8a->m7a) 0.287000 0.335000 No effect
hsa-miR-760 tgtaaAGAGCCattttcat
 7
 CGGCUCUG m6b Created -0.164000 -0.368000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.83641413G>T COSN14519289 8014573 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
83638253 rs189237262 A A hsa-miR-1323
hsa-miR-548o-3p
hsa-miR-551b-5p
0 GTTTTGAttttct
GTTTTGAttttct
gttTTGATTTtct
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.083
-0.086
-0.083
C hsa-miR-548e-5p
hsa-miR-548p
0 gtttTGCTTTTct
gTTTTGCTtttct
 Created
Created
N
N
 -0.178
-0.142
83638254 rs1047585 C G hsa-miR-1323
hsa-miR-548o-3p
hsa-miR-551b-5p
0 tGTTTTGAttttc
tGTTTTGAttttc
tgttTTGATTTtc
 Created
Created
Created
N
N
N
 -0.083
-0.086
-0.083
C hsa-miR-3646
hsa-miR-3662
hsa-miR-570-3p
0 tgttTTCATTTtc
tgtttTCATTTTc
TGTTTTCAttttc
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.08
-0.059
-0.278
83638254 rs11556198 C G hsa-miR-1323
hsa-miR-548o-3p
hsa-miR-551b-5p
0 tGTTTTGAttttc
tGTTTTGAttttc
tgttTTGATTTtc
 Created
Created
Created
N
N
N
 -0.083
-0.086
-0.083
C hsa-miR-3646
hsa-miR-3662
hsa-miR-570-3p
0 tgttTTCATTTtc
tgtttTCATTTTc
TGTTTTCAttttc
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.08
-0.059
-0.278
83638735 rs7706851 A G hsa-miR-122-3p
0 tATGGCGTttgta
 Created
N
 -0.343
A hsa-miR-105-5p
hsa-miR-5590-5p
hsa-miR-7853-5p
0 tatgGCATTTGta
TATGGCAtttgta
tatgGCATTTGta
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.104
-0.223
-0.122
83638738 rs189664946 G G hsa-miR-122-3p
0 aaatATGGCGTtt
 Disrupted
N
 -0.343
83638739 rs181148944 T T hsa-miR-122-3p
0 caaatATGGCGTt
 Disrupted
N
 -0.343
83639489 rs73133803 A A hsa-miR-643
hsa-miR-6500-3p
3
3
 gaaaATACAAGtg
gaaaatACAAGTG
 Disrupted
Disrupted
N
N
 -0.007
-0.038
C hsa-miR-1290
hsa-miR-3167
hsa-miR-3614-5p
hsa-miR-5004-3p
hsa-miR-876-5p
hsa-miR-890
1
2
3
2
2
4
 gAAAATCCAagtg
gaAAATCCAagtg
gaaaatCCAAGTG
gaaAATCCAAgtg
gaAAATCCAagtg
gaaaaTCCAAGTg
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 0.085
0.049
-0.075
0.008
0.049
-0.05
83639508 rs192011788 C C hsa-miR-5188
1
 atgtTCCGATAat
 Disrupted
N
 -0.173
T hsa-miR-2115-3p
hsa-miR-361-5p
hsa-miR-374a-3p
hsa-miR-589-3p
1
1
1
1
 atgTTCTGATAat
atgtTCTGATAAt
atgttCTGATAAt
aTGTTCTGAtaat
 Created
Created
Created
Created
N
N
N
N
 0.011
-0.059
-0.035
-0.059
83639627 rs181814510 G G hsa-miR-4793-5p
hsa-miR-5196-3p
hsa-miR-6870-3p
1
1
1
 gtctAGGATGAga
gtctAGGATGAga
gtctaGGATGAGA
 Disrupted
Disrupted
Disrupted
N
N
N
 0.018
0.016
-0.115
A hsa-miR-4305
hsa-miR-4777-5p
hsa-miR-518d-5p
hsa-miR-518e-5p
hsa-miR-518f-5p
hsa-miR-519a-5p
hsa-miR-519b-5p
hsa-miR-519c-5p
hsa-miR-520c-5p
hsa-miR-522-5p
hsa-miR-523-5p
hsa-miR-526a
hsa-miR-6758-3p
6
6
6
6
6
6
6
6
6
6
6
6
1
 GTCTAGAatgaga
gTCTAGAAtgaga
gTCTAGAAtgaga
gTCTAGAAtgaga
gTCTAGAAtgaga
gTCTAGAAtgaga
gTCTAGAAtgaga
gTCTAGAAtgaga
gTCTAGAAtgaga
gTCTAGAAtgaga
gTCTAGAAtgaga
gTCTAGAAtgaga
gtctaGAATGAGA
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
N
N
N
 -0.039
0.03
0.038
0.038
0.038
0.038
0.038
0.038
0.038
0.038
0.038
0.038
0.012
83640706 rs112884130 G G hsa-miR-1291
hsa-miR-328-3p
hsa-miR-6775-3p
hsa-miR-6851-3p
hsa-miR-938
7
7
7
6
12
 tctaAGGGCCAtt
tctaAGGGCCAtt
tctaAGGGCCAtt
tctAAGGGCCAtt
tcTAAGGGCcatt
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.168
-0.233
-0.158
-0.333
-0.15
A hsa-miR-6822-3p
hsa-miR-760
hsa-miR-8057
7
7
7
 tctaAGAGCCAtt
tctaAGAGCCAtt
tctaAGAGCCAtt
 Created
Created
Created
N
N
N
 -0.136
-0.101
-0.204

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