SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_020771
Gene Symbol:	HACE1
Description:	Homo sapiens HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (HACE1), mRNA.
Gene Location:	chr6(-):105175967-105307794
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.104728342C>T			COSN6719425		RK198_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4762-5p	attaAGATTTGGatgcttt	0	CCAAAUCU	m8a	Created	no TS	-0.182000	-4.780000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.104728460G>T			COSN5081783		HX35T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-186-5p	ctttaATTCTTTGgttttg	0	CAAAGAAU	m8a	Created	no TS	-0.063000	-0.090000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.104728540A>C			9_15793		CRC-3-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.104728658A>G			COSN5616941		RK125_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-223-5p	ggaacatgcATACACGaag	0	CGUGUAUU	m7a	(m7a->m6a)	NA	NA	0.470000
hsa-miR-4666b	ggaACATGCAtacacgaag	2	UUGCAUGU	m7b	(m7b->m6c)	-0.139000	no TS	1.380000
hsa-miR-675-3p	ggaacatGCATACAcgaag	2	CUGUAUGC	m7b	Disrupted	-0.145000	no TS	1.090000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.104729269G>T			COSN8493387		1428_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1226-3p	atccaGCTGGTGtgttctt	1	UCACCAGC	m7b	Disrupted	-0.229000	no TS	2.930000
hsa-miR-329	atccagctGGTGTGTTctt	1	AACACACC	m8a	Disrupted	-0.201000	no TS	9.130000
hsa-miR-362-3p	atccagctGGTGTGTTctt	1	AACACACC	m8a	Disrupted	-0.182000	no TS	1.920000
hsa-miR-5003-5p	atccagcTGTTGTGttctt	0	UCACAACA	m7b	Created	no TS	-0.108000	-1.610000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
104728652	rs187044862	G	G	hsa-miR-4659a-3p hsa-miR-4659b-3p hsa-miR-6875-3p	7 7 2	atacacGAAGAAA atacacGAAGAAA atacacGAAGAAA	Disrupted Disrupted Disrupted	N N N	-0.008 -0.008 0.007
			A	hsa-miR-223-5p hsa-miR-5010-3p hsa-miR-599 hsa-miR-6844	2 2 2 2	ATACACAaagaaa atACACAAAgaaa atACACAAAgaaa atacACAAAGAAa	Created Created Created Created	N N N N	-0.041 -0.094 -0.032 -0.097

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