SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_145740
Gene Symbol: GSTA1
Description: Homo sapiens glutathione S-transferase alpha 1 (GSTA1), mRNA.
Gene Location: chr6(-):52656177-52668664
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Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr6:g.52791482A>T COSN14460590 8068554 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-19a-3p ttttcaggTTTGCACAgga
0 UGUGCAAA m8a Created no TS -0.236000 -3.880000
hsa-miR-19b-3p ttttcaggTTTGCACAgga
0 UGUGCAAA m8a Created no TS -0.236000 -2.310000
hsa-miR-548aw ttttcaggTTTGCACagga
1
GUGCAAAA m7a Created -0.221000 -0.221000 No effect
hsa-miR-5689 ttttcagGTATGCacagga
0 AGCAUACA m6b Disrupted -0.143000 no TS 0.330000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.52791675A>C COSN9797163 AOCS-137-3-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4454 gttttcatTCGGATCtgat
0 GGAUCCGA m7b Created no TS -0.324000 -5.520000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.52791764G>C COSN5811093 EOPC-011_tumor [prostate][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4773 gtgcCTGTTCTGaagctaa
0 CAGAACAG m8a Created -0.093000 -0.212000 -4.060000
hsa-miR-5003-5p gtgccTGTTGTGAagctaa
1
UCACAACA m8a Disrupted -0.272000 no TS 1.630000
hsa-miR-589-3p gtgccTGTTCTGAagctaa
0 UCAGAACA m8a Created no TS -0.240000 -6.730000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.52791801A>T COSN9908948 C0010T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4684-3p ttTTGCAACAataaagtac
1
UGUUGCAA m8a (m8a->m7b) -0.422000 -0.270000 -0.210000
hsa-miR-5701 ttttgcaACAATAAagtac
0 UUAUUGUC m7a Disrupted -0.052000 no TS -0.170000
hsa-miR-744-3p ttttGCAACAataaagtac
2
CUGUUGCC m6b Disrupted -0.179000 no TS -0.190000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
52791798 rs699334 A A hsa-miR-5701
4
aACAATAAagtac
Disrupted
N
-0.052
52791801 rs73740640 A A hsa-miR-4684-3p
hsa-miR-5701
hsa-miR-744-3p
1
4
2
TGCAACAataaag
tgcaACAATAAag
tGCAACAAtaaag
Disrupted
Disrupted
Disrupted
N
N
N
-0.179
-0.052
-0.179
C hsa-miR-218-2-3p
hsa-miR-584-5p
hsa-miR-656-5p
hsa-miR-758-5p
3
3
2
2
tgcAACCATAaag
tgcAACCATAAag
tGCAACCAtaaag
tgCAACCATAaag
Created
Created
Created
Created
N
N
N
N
-0.129
-0.274
-0.239
-0.374
52791819 rs1052027 G G hsa-miR-4773
hsa-miR-5687
1
21
accaaTGTTCTAa
accaatGTTCTAA
Disrupted
Disrupted
N
N
-0.093
-0.135

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