SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_031415
Gene Symbol: GSDMC
Description: Homo sapiens gasdermin C (GSDMC), mRNA.
Gene Location: chr8(-):130760441-130799134
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr8:g.129748255G>A COSN4876806 tumor_4188900 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-511 gttAAAGACAtaagcgttt
0 GUGUCUUU m7b (m6c->m7b) no TS -0.189000 -0.140000
hsa-miR-654-3p gttaaAGACATAagcgttt
0 UAUGUCUG m7a Created no TS -0.133000 -4.560000


Mutation Mutation ID Sample Name Cancer Type
chr8:g.129748256C>T COSN15397146 0008_CRUK_PC_0008_T1_DNA [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr8:g.129748293T>G COSN9255609 C0031T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1277-5p aagagtttATATATTTgtc
2
AAAUAUAU m8a Disrupted -0.154000 -0.086000 0.020000
hsa-miR-4799-5p aagagTTTAGATatttgtc
0 AUCUAAAU m7a Created NA NA -1.600000
hsa-miR-5011-5p aagagttTATATATttgtc
2
UAUAUAUA m7b Disrupted -0.140000 -0.055000 -1.170000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
129748255 rs111395458 G
A hsa-miR-511-5p
hsa-miR-654-3p
hsa-miR-6830-3p
0 AAAGACAtaagcg
aaAGACATAagcg
AAAGACAtaagcg
Created
Created
Created
N
N
N
-0.189
-0.133
-0.095

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