SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_005308
Gene Symbol: GRK5
Description: Homo sapiens G protein-coupled receptor kinase 5 (GRK5), mRNA.
Gene Location: chr10(+):120967196-121215131
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Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr10:g.119455112C>A COSN8639145 J90_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1182 gcccAGACCCTtctcctta
 4
 GAGGGUCU m7b Disrupted -0.157000 no TS 12.240000
hsa-miR-3154 gcccagaCCCTTCTcctta
 3
 CAGAAGGG m7b Disrupted -0.194000 no TS 11.540000
hsa-miR-4434 gcccagaccCTTCTCCTta
 2
 AGGAGAAG m8a (m8a->m7b) -0.117000 no TS 1.470000
hsa-miR-4516 gcccagaccCTTCTCCtta
 2
 GGGAGAAG m7b (m7b->m6c) -0.154000 no TS 5.570000
hsa-miR-4790-3p gcccagACCATTCtcctta
 0 UGAAUGGU m7b Created no TS -0.098000 -7.130000
hsa-miR-5703 gcccagaccCTTCTCCTta
 2
 AGGAGAAG m8a (m8a->m7b) -0.117000 no TS -1.030000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.119455181G>A COSN6943597 8035543 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-149-5p ccggGAGCCAGggaaggag
 0 UCUGGCUC m7b Created no TS -0.105000 -0.370000
hsa-miR-4292 ccgggagCCAGGGaaggag
 0 CCCCUGGG m6b Created no TS -0.118000 No effect
hsa-miR-4308 ccgggagCCAGGGAaggag
 0 UCCCUGGA m7a Created no TS -0.131000 3.070000
hsa-miR-4707-5p ccgggaGCCGGGGaaggag
 6
 GCCCCGGC m7b Disrupted -0.854000 -0.273000 0.010000
hsa-miR-5587-3p ccgggagCCGGGGaaggag
 7
 GCCCCGGG m6b Disrupted -0.214000 no TS 4.900000
hsa-miR-670 ccgggagcCAGGGAaggag
 0 GUCCCUGA m6b Created no TS -0.081000 2.490000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.119455205C>T COSN2381246 TCGA-D1-A17H-01 [endometrium][NS][carcinoma][endometrioid_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-95 ccatcCCGTTGAcgtagaa
 0 UUCAACGG m7b Created no TS -0.180000 -4.310000
hsa-miR-95 ccatcCCGTTGAcgtagaa
 0 UUCAACGG m7b Created no TS -0.18 -4.31

Mutation Mutation ID Sample Name Cancer Type
chr10:g.119455256C>T COSN1079937 TCGA-B5-A11E-01 [endometrium][NS][carcinoma][endometrioid_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-570-3p gtcTGTTTTCcgaggcggc
 9
 CGAAAACA m7b (m7b->m6b) 0.066000 no TS 2.610000
hsa-miR-570-3p gtcTGTTTTCcgaggcggc
 9
 CGAAAACA m7b (m7b->m6b) 0.066 no TS 2.61

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
119455251 rs12721548 G G hsa-miR-570-3p
9
 aggtcTGTTTTCc
 Disrupted
N
 0.066
A hsa-miR-3121-3p
hsa-miR-3684
16
19
 aggTCTATTTtcc
AGGTCTAttttcc
 Created
Created
N
N
 0.062
-0.175

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