SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_017551
Gene Symbol:	GRID1
Description:	Homo sapiens glutamate receptor, ionotropic, delta 1 (GRID1), mRNA.
Gene Location:	chr10(-):87359311-88126250
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.85599919A>T			COSN15072410		LP6005690-DNA_A02		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1229	gtgtgtGTGAGAGagagag	0	CUCUCACC	m7a	Disrupted	-0.149000	-0.149000	-0.120000
hsa-miR-342-3p	gtgtGTGTGAGAgagagag	0	UCUCACAC	m8a	Disrupted	-0.253000	-0.254000	-0.390000
hsa-miR-377-3p	gtgTGTGTGAgagagagag	0	AUCACACA	m7b	(m7b->m6c)	-0.072000	-0.073000	-0.080000
hsa-miR-603	gtgtGTGTGTGagagagag	0	CACACACU	m7a	Created	NA	NA	-0.500000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.85599940T>G			ICGC_A7856B36-2A78-11E2-8335-12FD496BB9B8		CPCG_0102_Pr_P_P2		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.85600813C>A			11_3420		2542		Breast cancer
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-218-5p	cagggAAGCACAgttttct	3	UUGUGCUU	m7b	Created	0.035	0.111	No effect
hsa-miR-27a-5p	cagggAAGCCCagttttct	3	AGGGCUUA	m6b	Disrupted	-0.023	no TS	0.13
hsa-miR-378g	cagggaAGCCCAGTtttct	3	ACUGGGCU	m8a	Disrupted	-0.251	-0.177	-0.15
hsa-miR-5008-3p	cagggaAGCACAGttttct	3	CCUGUGCU	m7b	Created	no TS	-0.034	-2.63
hsa-miR-516a-3p	cagGGAAGCAcagttttct	3	UGCUUCCU	m7a	(m6b->m7a)	0.046	0.044	-0.01
hsa-miR-516b-3p	cagGGAAGCAcagttttct	3	UGCUUCCU	m7a	(m6b->m7a)	0.046	0.044	-0.01
hsa-miR-636	cagggAAGCACAgttttct	3	UGUGCUUG	m7a	Created	no TS	0.047	-0.03

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.85600841C>G			COSN5254699		HX30T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5191	caggCCTATCCctgtgcag	1	AGGAUAGG	m7b	Disrupted	-0.001000	no TS	0.280000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.85601046T>C			COSN8724212		AOCS-166-1-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-185-3p	agttgcttgCAGCCCCaaa	2	AGGGGCUG	m7b	(m6b->m7b)	-0.075000	-0.181000	-0.160000
hsa-miR-187-5p	agttgcTTGTAGCCccaaa	3	GGCUACAA	m8a	Disrupted	0.062000	no TS	No effect
hsa-miR-2276	agttgCTTGCAGccccaaa	0	UCUGCAAG	m7b	Created	no TS	0.065000	No effect
hsa-miR-4489	agttgcttgTAGCCCCAaa	2	UGGGGCUA	m8a	(m8a->m7a)	-0.194000	-0.104000	-0.010000
hsa-miR-4492	agttgcttgCAGCCCCaaa	6	GGGGCUGG	m7a	(m6a->m7a)	-0.049000	-0.049000	No effect
hsa-miR-4675	agttgcttgCAGCCCCaaa	5	GGGGCUGU	m7a	(m6a->m7a)	-0.171000	-0.171000	No effect
hsa-miR-762	agttgcttgCAGCCCCaaa	6	GGGGCUGG	m7a	(m6a->m7a)	-0.045000	-0.045000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.85601145G>A			COSN1504956		RK050_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-138-2-3p	tgaGAAATAGagaaaagag	2	GCUAUUUC	m7b	(m7b->m6c)	0.088000	no TS	No effect
hsa-miR-4684-5p	tgagaaaTAGAGAaaagag	3	CUCUCUAC	m6b	Disrupted	0.020000	no TS	No effect
hsa-miR-4768-5p	tgagaaatAGAGAAaagag	1	AUUCUCUC	m6b	Disrupted	0.077000	0.024000	No effect
hsa-miR-138-2-3p	tgaGAAATAGagaaaagag	2	GCUAUUUC	m7b	(m7b->m6c)	0.088000	no TS	No effect
hsa-miR-4684-5p	tgagaaaTAGAGAaaagag	3	CUCUCUAC	m6b	Disrupted	0.020000	no TS	No effect
hsa-miR-4768-5p	tgagaaatAGAGAAaagag	1	AUUCUCUC	m6b	Disrupted	0.077000	0.024000	No effect
hsa-miR-138-2-3p	tgaGAAATAGagaaaagag	0	GCUAUUUC	m7b	(m7b->m6c)	0.088	no TS	No effect
hsa-miR-4684-5p	tgagaaaTAGAGAaaagag	0	CUCUCUAC	m6b	Disrupted	0.02	no TS	No effect
hsa-miR-4768-5p	tgagaaatAGAGAAaagag	0	AUUCUCUC	m6b	Disrupted	0.077	0.024	3.8

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
85599917	rs148220959	-	-	hsa-miR-342-3p hsa-miR-6817-3p hsa-miR-6873-3p hsa-miR-7110-3p	0	gtGTGTGAGAgagagagag gtgtgtgAGAGAGAgagag gtgtgtgAGAGAGAgagag gtgtgtGAGAGAGAgagag	Unknown Unknown Unknown Unknown	N N N N	-0.123 -0.062 -0.079 -0.317
			GTGA	hsa-miR-1306-5p hsa-miR-412-3p hsa-miR-6754-3p hsa-miR-6837-3p	1 6 6 9	gtgtgtGAGGTGAagagagagag gtgtgtgaGGTGAAGAgagagag gtgtgtgaGGTGAAGAgagagag gtgtgtgagGTGAAGAgagagag	Unknown Unknown Unknown Unknown	N N N N	-0.105 -0.297 -0.255 -0.054
85599917	rs201262498	T	A	hsa-miR-342-3p hsa-miR-6817-3p hsa-miR-6873-3p hsa-miR-7110-3p	0	TGTGAGAgagaga tgtgAGAGAGAga tgtgAGAGAGAga tgtGAGAGAGAga	Created Created Created Created	N N N N	-0.119 -0.106 -0.217 -0.47
			T	hsa-miR-1304-3p	1	tgtgAGTGAGAga	Disrupted	N	-0.046
85599919	rs12253218	T	A	hsa-miR-342-3p hsa-miR-377-3p hsa-miR-6817-3p hsa-miR-6873-3p hsa-miR-7110-3p	0	tGTGTGAGAgaga TGTGTGAgagaga tgtgtgAGAGAGA tgtgtgAGAGAGA tgtgtGAGAGAGA	Created Created Created Created Created	N N N N N	0.001 0.001 -0.053 -0.132 -0.261
85599920	rs72199904	-	-	hsa-miR-342-3p hsa-miR-377-3p hsa-miR-7110-3p	0	tgtgtGTGTGAGAgagaga tgtgTGTGTGAgagagaga tgtgtgtgtGAGAGAGAga	Unknown Unknown Unknown	N N N	-0.253 -0.072 0.019
			TGAG
85599921	rs56731174	T	T	hsa-miR-342-3p hsa-miR-377-3p	0	tgtGTGTGAGAga tgTGTGTGAgaga	Disrupted Disrupted	N N	-0.002 -0.002
			A	hsa-miR-6817-3p hsa-miR-6873-3p hsa-miR-7110-3p	1 1 1	tgtgtgAGAGAGA tgtgtgAGAGAGA tgtgtGAGAGAGA	Created Created Created	N N N	-0.053 -0.132 -0.26
85600458	rs80108137	-	G	hsa-miR-378g hsa-miR-664b-5p hsa-miR-939-3p	2 3 2	taactAGCCCAGg taacTAGCCCAgg taactaGCCCAGG	Unknown Unknown Unknown	N N N	-0.178 -0.131 -0.214
			A	hsa-miR-6742-3p	2	taactaACCCAGG	Unknown	N	-0.176

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