| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_013372 |
|---|---|
| Gene Symbol: | GREM1 |
| Description: | Homo sapiens gremlin 1 (GREM1), transcript variant 3, mRNA. |
| Gene Location: | chr15(+):33010204-33026870 |
| Browse Associations | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr15:g.32731634C>T | COSN8589809 | J90_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-2114-3p |
gaaGAGGCTCctctgaggg |
2 |
CGAGCCUC | m7b | (m7b->m6b) | -0.211000 | no TS |
0.010000 |
|
| hsa-miR-3123 |
gaagaggcTTCTCTGaggg |
0 | CAGAGAAU | m7a | Created | NA | NA | No effect | |
| hsa-miR-3919 |
gaagaggcTTCTCTGaggg |
3 |
GCAGAGAA | m7b | Created | -0.145000 | -0.211000 |
-0.010000 |
|
| hsa-miR-4257 |
gaagaggctCCTCTGaggg |
2 |
CCAGAGGU | m6b | Disrupted | -0.052000 | 0.009000 | No effect | |
| hsa-miR-4756-3p |
gaagaggctTCTCTGaggg |
3 |
CCAGAGAU | m6b | Created | -0.045000 | -0.085000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr15:g.32732001A>C | COSN8741984 | AOCS-058-1-5 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-298 |
atgCTTCTGCgaaagtctt |
0 | AGCAGAAG | m7b | (m6b->m7b) | no TS | -0.064000 | No effect | |
| hsa-miR-4330 |
atgctTCTGAGaaagtctt |
1 |
CCUCAGAU | m6b | Disrupted | 0.095000 | 0.152000 |
2.060000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr15:g.32732084T>C | COSN8589810 | J74_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4485 |
tttGGCCGTTgcaatctgc |
1 |
UAACGGCC | m7b | (m7b->m6b) | -0.265000 | no TS |
8.460000 |
|
| hsa-miR-891a |
tttggcCGTTGCAatctgc |
0 | UGCAACGA | m7a | Disrupted | -0.154000 | no TS |
3.270000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr15:g.32733343G>T | COSN8589811 | 522_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1304-3p |
ccacacCAGTGAGgaaaaa |
3 |
UCUCACUG | m7b | Created | -0.011000 | 0.015000 |
-0.010000 |
|
| hsa-miR-4292 |
ccacaCCAGGGaggaaaaa |
1 |
CCCCUGGG | m6b | Disrupted | -0.032000 | no TS |
3.970000 |
|
| hsa-miR-4691-5p |
ccacaccagGGAGGAaaaa |
9 |
GUCCUCCA | m6b | Disrupted | -0.154000 | -0.111000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr15:g.32734231A>G | COSN6270713 | RK201_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-137 |
tctaaAGCAATAttaagaa |
0 | UUAUUGCU | m7b | Disrupted | -0.211000 | no TS |
-0.970000 |
|
| hsa-miR-200b-3p |
tctaaagCAGTATTAagaa |
1 |
UAAUACUG | m8a | Created | 0.031000 | -0.152000 |
-0.100000 |
|
| hsa-miR-200c-3p |
tctaaagCAGTATTAagaa |
1 |
UAAUACUG | m8a | Created | 0.031000 | -0.152000 |
-0.010000 |
|
| hsa-miR-374c-5p |
tctaaagcaGTATTAagaa |
8 |
AUAAUACA | m6b | Created | -0.042000 | -0.039000 |
-0.010000 |
|
| hsa-miR-429 |
tctaaagCAGTATTAagaa |
1 |
UAAUACUG | m8a | Created | 0.031000 | -0.142000 |
-0.020000 |
|
| hsa-miR-655 |
tctaaagcaGTATTAagaa |
8 |
AUAAUACA | m6b | Created | 0.024000 | 0.027000 |
-0.060000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr15:g.32734622T>C | COSN8589812 | J46_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-4999-5p |
tgttctATACAGCctttgc |
0 | UGCUGUAU | m7b | Created | no TS | -0.233000 |
-0.020000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 32732705 | rs150874443 | A | A |
hsa-miR-200b-3p hsa-miR-200c-3p hsa-miR-429 hsa-miR-4724-5p |
1 1 1 3 |
ttCAGTATTtact ttCAGTATTtact ttCAGTATTtact TTCAGTAtttact |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
0.031 0.031 0.031 0.046 |
| G |
hsa-miR-141-3p hsa-miR-200a-3p hsa-miR-30a-5p hsa-miR-30b-5p hsa-miR-30c-5p hsa-miR-30d-5p hsa-miR-30e-5p |
1 1 1 1 1 1 1 |
ttCAGTGTTtact ttCAGTGTTtact ttcagTGTTTACt ttcagTGTTTACt ttcagTGTTTACt ttcagTGTTTACt ttcagTGTTTACt |
Created Created Created Created Created Created Created |
N N N N N N N |
-0.009 -0.009 0.12 0.12 0.12 0.12 0.101 |
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| 32733345 | rs182520997 | A | A |
hsa-miR-1238-3p hsa-miR-4292 hsa-miR-4308 hsa-miR-4691-5p hsa-miR-670-3p hsa-miR-6749-3p hsa-miR-6791-5p hsa-miR-6792-3p hsa-miR-7113-3p |
11 1 1 1 11 1 1 1 1 |
ccaggGAGGAAAa CCAGGGAggaaaa CCAGGGAggaaaa ccagGGAGGAAaa ccaggGAGGAAAa ccaGGGAGGAAaa CCAGGGAggaaaa ccagGGAGGAAaa cCAGGGAGgaaaa |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N |
0.012 -0.032 -0.042 -0.043 0.03 -0.183 -0.032 -0.04 -0.021 |
| G |
hsa-miR-331-3p hsa-miR-3679-3p hsa-miR-4446-5p |
1 1 11 |
CCAGGGGggaaaa ccagGGGGGAAAa ccagggGGGAAAA |
Created Created Created |
N N N |
-0.096 -0.103 0.058 |