SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_002086
Gene Symbol: GRB2
Description: Homo sapiens growth factor receptor-bound protein 2 (GRB2), transcript variant 1, mRNA.
Gene Location: chr17(-):73314156-73401789
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr17:g.75319299A>C COSN1728938 RK062_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr17:g.75319565C>G ICGC_B020B78C-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3155a acttggGAGCCTGaggcag
 0 CCAGGCUC m7b Disrupted -0.289 -0.126 0.04
hsa-miR-3155b acttggGAGCCTGaggcag
 0 CCAGGCUC m7b Disrupted -0.289 -0.126 0.02
hsa-miR-484 acttggGAGCCTGAggcag
 0 UCAGGCUC m8a Disrupted -0.287 -0.145 0.71

Mutation Mutation ID Sample Name Cancer Type
chr17:g.75320001T>C COSN5420647 RK102_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1202 gtggGCTGGCAttctctct
 0 GUGCCAGC m7b Created no TS -0.232000 -0.880000
hsa-miR-3194-5p gtgGGCTGGCattctctct
 0 GGCCAGCC m7b (m6c->m7b) no TS -0.457000 -0.090000
hsa-miR-3972 gtggGCTGGCAttctctct
 0 CUGCCAGC m7b Created no TS -0.213000 -0.950000
hsa-miR-634 gtggGCTGGTattctctct
 13
 AACCAGCA m6b Disrupted -0.165000 no TS 2.060000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.75320155T>G COSN6111999 RK122_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548ae taagaagAGTTTTTattac
 14
 CAAAAACU m7b Disrupted -0.101000 no TS 1.150000
hsa-miR-548ah-3p taagaagAGTTTTTattac
 14
 CAAAAACU m7b Disrupted -0.101000 no TS 0.120000
hsa-miR-548aj-3p taagaagAGTTTTTAttac
 14
 UAAAAACU m8a Disrupted -0.101000 no TS 1.150000
hsa-miR-548am-3p taagaagAGTTTTTattac
 14
 CAAAAACU m7b Disrupted -0.101000 no TS 0.110000
hsa-miR-548aq-3p taagaagAGTTTTTattac
 14
 CAAAAACU m7b Disrupted -0.101000 no TS 0.526000
hsa-miR-548at-3p taagaagaGGTTTTattac
 0 CAAAACCG m6b Created no TS -0.086000 No effect
hsa-miR-548e taagaagAGTTTTTattac
 0 AAAAACUG m7a Disrupted NA NA No effect
hsa-miR-548f taagaagAGTTTTTattac
 0 AAAAACUG m7a Disrupted NA NA 0.520000
hsa-miR-548x-3p taagaagAGTTTTTAttac
 14
 UAAAAACU m8a Disrupted -0.101000 no TS 1.150000
hsa-miR-877-3p taaGAAGAGGttttattac
 0 UCCUCUUC m7b (m6c->m7b) no TS -0.272000 -0.100000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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