SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_012201
Gene Symbol: GLG1
Description: Homo sapiens golgi glycoprotein 1 (GLG1), transcript variant 2, mRNA.
Gene Location: chr16(-):74481325-74641042
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr16:g.74449390T>A COSN407725 TCGA-BH-A0HN-01 [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4511 agaagattcAGTTCTTatg
0 GAAGAACU m7b (m6b->m7b) 0.103000 0.152000 No effect
hsa-miR-4773 agaagattCTGTTCTtatg
0 CAGAACAG m7b Disrupted -0.077000 -0.102000 0.250000
hsa-miR-5187-3p agaaGATTCAGTtcttatg
0 ACUGAAUC m8a Created no TS 0.006000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr16:g.74449752G>A COSN4767227 tumor_4142267 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-376c tgcagtTCTATGTTagtgc
15
AACAUAGA m8a Created -0.344000 -0.258000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr16:g.74451560C>G 9_136254 CRC-1-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2467-3p cactcttgCCTCTGCTctg
5
AGCAGAGG m8a Disrupted -0.231 -0.108 0.03
hsa-miR-31-5p cacTCTTGCCTctgctctg
3
AGGCAAGA m8a Disrupted -0.107 -0.043 4.68

Mutation Mutation ID Sample Name Cancer Type
chr16:g.74451824C>T COSN522274 TCGA-A2-A0EV-01 [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1827 tggccatcCTGCCTCAttc
2
UGAGGCAG m8a Created -0.103000 -0.432000 No effect
hsa-miR-2392 tggCCATCCTgcctcattc
1
UAGGAUGG m7b (m6c->m7b) 0.070000 -0.070000 No effect
hsa-miR-3197 tggccatccCGCCTCattc
1
GGAGGCGC m6b Disrupted -0.290000 -0.068000 No effect
hsa-miR-940 tggccatCCTGCCTcattc
0 AAGGCAGG m7b Created 0.030000 -0.177000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr16:g.74451922G>T COSN1190544 BN03T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1225-5p ttgctgcgtGTACCCACtc
6
GUGGGUAC m8a (m8a->m7a) -0.249000 no TS 0.220000
hsa-miR-555 ttgctgcgtTTACCCactc
0 AGGGUAAG m6b Created no TS -0.110000 -0.050000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
74449389 rs11149721 C G hsa-miR-4511
hsa-miR-4773
hsa-miR-548b-3p
0 gattctGTTCTTA
gattCTGTTCTta
gattctGTTCTTA
Created
Created
Created
N
N
N
0.103
0.025
0.094
C hsa-miR-3123
hsa-miR-3653
hsa-miR-5197-3p
0 gATTCTCTtctta
gattctCTTCTTA
gattCTCTTCTta
Disrupted
Disrupted
Disrupted
N
N
N
0.124
0.108
0.018
74449390 rs75534023 T T hsa-miR-4773
0 agattCTGTTCTt
Disrupted
N
0.025
A hsa-miR-4511
hsa-miR-5187-3p
0 agattcAGTTCTT
aGATTCAGttctt
Created
Created
N
N
0.049
0.006
74450231 rs111483912 G G hsa-miR-1972
3
gactcTGGCCTGt
Disrupted
N
0.002
T hsa-miR-31-5p
hsa-miR-4742-5p
3
3
gacTCTTGCCtgt
gactcTTGCCTGt
Created
Created
N
N
0.029
0.048
74450946 rs181743464 T T hsa-miR-3133
hsa-miR-4773
6
4
tttctGTTCTTTc
tttCTGTTCTttc
Disrupted
Disrupted
N
N
0.011
-0.102
A hsa-miR-2115-3p
hsa-miR-383-5p
5
4
tTTCTGATctttc
ttTCTGATCtttc
Created
Created
N
N
-0.035
-0.138
74451824 rs3851730 C C hsa-miR-3197
hsa-miR-6087
hsa-miR-6765-5p
1
1
1
ccatccCGCCTCA
ccatcCCGCCTCA
ccatccCGCCTCA
Disrupted
Disrupted
Disrupted
N
N
N
-0.222
-0.481
-0.216
T hsa-miR-1827
hsa-miR-2392
hsa-miR-6808-5p
hsa-miR-6893-5p
hsa-miR-940
1
2
1
1
1
ccatcCTGCCTCA
CCATCCTgcctca
ccatCCTGCCTca
ccatCCTGCCTca
ccatCCTGCCTca
Created
Created
Created
Created
Created
N
N
N
N
N
-0.329
-0.14
-0.217
-0.207
-0.207

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