SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000404
Gene Symbol:	GLB1
Description:	Homo sapiens galactosidase, beta 1 (GLB1), transcript variant 1, mRNA.
Gene Location:	chr3(-):33038099-33138694
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Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.32996934A>C			COSN1276086		BN40T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5009-3p	gaATTTAGGAtgtgcattt	0	UCCUAAAU	m8a	(m8a->m7b)	-0.240000	-0.112000	0.690000
hsa-miR-5009-3p	gaATTTAGGAtgtgcattt	0	UCCUAAAU	m8a	(m8a->m7b)	-0.240000	-0.112000	0.690000
hsa-miR-5009-3p	gaATTTAGGAtgtgcattt	0	UCCUAAAU	m8a	(m8a->m7b)	-0.24	-0.112	0.69

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.32997004T>C			COSN15379815		0007_CRUK_PC_0007_T1_DNA		[prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-let-7d-5p	ccctgaacaTACCTCacag	7	AGAGGUAG	m6b	Disrupted	-0.122000	no TS	6.060000
hsa-miR-124-5p	cccTGAACACacctcacag	0	CGUGUUCA	m7b	(m6c->m7b)	no TS	-0.241000	-2.130000
hsa-miR-202-3p	ccctgaacATACCTCacag	6	AGAGGUAU	m7b	Disrupted	-0.310000	no TS	10.340000
hsa-miR-3650	ccctgaACACACCTcacag	0	AGGUGUGU	m8a	Created	no TS	-0.232000	-1.140000
hsa-miR-4458	ccctgaacaTACCTCacag	7	AGAGGUAG	m6b	Disrupted	-0.125000	no TS	2.880000
hsa-miR-567	ccctgAACATACctcacag	1	AGUAUGUU	m7b	Disrupted	-0.090000	no TS	3.860000
hsa-let-7d-5p	ccctgaacaTACCTCacag	7	AGAGGUAG	m6b	Disrupted	-0.122000	no TS	6.060000
hsa-miR-124-5p	cccTGAACACacctcacag	0	CGUGUUCA	m7b	(m6c->m7b)	no TS	-0.241000	-2.130000
hsa-miR-202-3p	ccctgaacATACCTCacag	6	AGAGGUAU	m7b	Disrupted	-0.310000	no TS	10.340000
hsa-miR-3650	ccctgaACACACCTcacag	0	AGGUGUGU	m8a	Created	no TS	-0.232000	-1.140000
hsa-miR-4458	ccctgaacaTACCTCacag	7	AGAGGUAG	m6b	Disrupted	-0.125000	no TS	2.880000
hsa-miR-567	ccctgAACATACctcacag	1	AGUAUGUU	m7b	Disrupted	-0.090000	no TS	3.860000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
32997001	rs199659949	C	C	hsa-let-7a-5p hsa-let-7b-5p hsa-let-7c-5p hsa-let-7d-5p hsa-let-7e-5p hsa-let-7f-5p hsa-let-7g-5p hsa-let-7i-5p hsa-miR-1294 hsa-miR-202-3p hsa-miR-4316 hsa-miR-4458 hsa-miR-4500 hsa-miR-4677-3p hsa-miR-98-5p	7 7 7 7 7 7 7 7 3 6 3 7 7 2 7	acaTACCTCAcag acaTACCTCAcag acaTACCTCAcag acaTACCTCAcag acaTACCTCAcag acaTACCTCAcag acaTACCTCAcag acaTACCTCAcag acatACCTCACAg acATACCTCAcag acataCCTCACAg acaTACCTCAcag acaTACCTCAcag acatacCTCACAG acaTACCTCAcag	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N N N N N	-0.125 -0.122 -0.125 -0.122 -0.125 -0.125 -0.125 -0.122 -0.412 -0.31 -0.16 -0.125 -0.125 -0.214 -0.125
			T	hsa-miR-3611 hsa-miR-548ao-5p hsa-miR-548ax hsa-miR-5585-5p	3 7 7 7	acataCTTCACAg acaTACTTCAcag acaTACTTCAcag acaTACTTCAcag	Created Created Created Created	N N N N	-0.165 -0.069 -0.069 -0.069

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